Scientists integrated genome-wide chromosome conformation data from purified neurons and glia with transcriptomic and enhancer profiles, to characterize the gene regulatory landscape of two major cell classes in the human brain.
[Nature Communications]
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Hu, B., Won, H., Mah, W., Park, R. B., Kassim, B., Spiess, K., Kozlenkov, A., Crowley, C. A., Pochareddy, S., Li, Y., Dracheva, S., Sestan, N., Akbarian, S., & Geschwind, D. H. (2021). Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders. Nature Communications, 12(1), 3968. https://doi.org/10.1038/s41467-021-24243-0 Cite
