CVnCoV and CV2CoV Protect Human ACE2 Transgenic Mice from Ancestral B BavPat1 and Emerging B.1.351 SARS-CoV-2

The efficacy of spike encoding mRNA vaccines against the ancestral strain and the VOC B.1.351 was tested in a K18-hACE2 transgenic mouse model. Naive mice and mice immunized with a formalin-inactivated SARS-CoV-2 preparation were used as controls.