Scientists generated a series of deuterated variants of a 3CLpro inhibitor, GC376, and evaluated the antiviral effect against SARS-CoV-2.
[Proceedings of the National Academy of Sciences of the United States of America]
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Dampalla, C. S., Zheng, J., Perera, K. D., Wong, L.-Y. R., Meyerholz, D. K., Nguyen, H. N., Kashipathy, M. M., Battaile, K. P., Lovell, S., Kim, Y., Perlman, S., Groutas, W. C., & Chang, K.-O. (2021). Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection. Proceedings of the National Academy of Sciences, 118(29). https://doi.org/10.1073/pnas.2101555118 Cite
