Researchers defined crucial in vivo functions of the death receptor-mediated and BCL-2-regulated apoptosis pathways in mediating protection against tuberculosis by eliminating distinct populations of infected macrophages and neutrophils and priming T cell responses.
[Immunity]
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Stutz, M. D., Allison, C. C., Ojaimi, S., Preston, S. P., Doerflinger, M., Arandjelovic, P., Whitehead, L., Bader, S. M., Batey, D., Asselin-Labat, M.-L., Herold, M. J., Strasser, A., West, N. P., & Pellegrini, M. (2021). Macrophage and neutrophil death programs differentially confer resistance to tuberculosis. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2021.06.009 Cite
