While investigating B cell subsets among individuals recently infected with HIV, the authors observe an accumulation of CD27−CD38+ B cells and find that these cells can directly facilitate HIV infection of primary CD4+ T cells in vitro.
[Cell Reports]
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Fu, Y., Zhang, Z., Yang, Z., Jiang, Y., Han, X., Xu, J., Chu, Z., Ding, H., He, S., & Shang, H. (2021). CD27−CD38+ B cells accumulated in early HIV infection exhibit transitional profile and promote HIV disease progression. Cell Reports, 36(2). https://doi.org/10.1016/j.celrep.2021.109344 Cite
