The authors discuss perturbation of cell death in prostate cancer and how new therapeutics could improve treatment outcome in prostate cancer.
[Cancer Letters]
6445218
{6445218:FJSXRRQE}
apa
50
1
165398
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-1076ea8ba80e1d08255821c7f165157e%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22FJSXRRQE%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Campbell%20and%20Leung%22%2C%22parsedDate%22%3A%222021-07-31%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ECampbell%2C%20K.%20J.%2C%20%26amp%3B%20Leung%2C%20H.%20Y.%20%282021%29.%20Evasion%20of%20cell%20death%3A%20A%20contributory%20factor%20in%20prostate%20cancer%20development%20and%20treatment%20resistance.%20%3Ci%3ECancer%20Letters%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.canlet.2021.07.045%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.canlet.2021.07.045%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DFJSXRRQE%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Evasion%20of%20cell%20death%3A%20A%20contributory%20factor%20in%20prostate%20cancer%20development%20and%20treatment%20resistance%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kirsteen%20J.%22%2C%22lastName%22%3A%22Campbell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hing%20Y.%22%2C%22lastName%22%3A%22Leung%22%7D%5D%2C%22abstractNote%22%3A%22Cell%20death%20is%20a%20natural%20process%20in%20organismal%20development%2C%20homeostasis%20and%20response%20to%20disease%20or%20infection%20that%20eliminates%20unnecessary%20or%20potentially%20dangerous%20cells%20and%20acts%20as%20an%20innate%20barrier%20to%20oncogenesis.%20Inactivation%20of%20cell%20death%20is%20a%20key%20step%20in%20tumour%20development%20and%20also%20impedes%20effective%20response%20to%20cancer%20therapy.%20Precise%20execution%20of%20unwanted%20cells%20is%20achieved%20through%20regulated%20cell%20death%20processes%20including%20the%20intrinsic%20apoptotic%20pathway%20that%20is%20governed%20by%20the%20BCL-2%20%28B-cell%20lymphoma%202%29%20protein%20family.%20There%20is%20compelling%20evidence%20that%20intrinsic%20apoptosis%20is%20defective%20in%20prostate%20cancer%2C%20particularly%20in%20metastatic%20and%20castration%20resistant%20advanced%20disease%2C%20currently%20a%20lethal%20diagnosis.%20New%20therapeutics%20have%20been%20developed%20to%20target%20pro-survival%20BCL-2%20proteins%20%28including%20BCL-2%2C%20BCL-XL%20and%20MCL-1%29%20and%20show%20promise%20in%20reinstating%20apoptosis%20to%20destroy%20tumour%20cells%20in%20haematological%20cancers.%20Here%20we%20discuss%20perturbation%20of%20cell%20death%20in%20prostate%20cancer%20and%20how%20new%20therapeutics%20could%20improve%20treatment%20outcome%20in%20prostate%20cancer.%22%2C%22date%22%3A%22July%2031%2C%202021%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.canlet.2021.07.045%22%2C%22ISSN%22%3A%220304-3835%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0304383521003785%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-08-05T23%3A07%3A02Z%22%7D%7D%5D%7D
Campbell, K. J., & Leung, H. Y. (2021). Evasion of cell death: A contributory factor in prostate cancer development and treatment resistance. Cancer Letters. https://doi.org/10.1016/j.canlet.2021.07.045 Cite
