Microglia Promote Autoimmune Inflammation via the Noncanonical NF-κB Pathway

Data suggest that following their initial central nervous system infiltration, T cells activate the microglial noncanonical NF-κB pathway, which synergizes with the T cell-derived cytokine granulocyte-macrophage colony-stimulating factor to induce expression of chemokines involved in the second-wave of T cell recruitment and disease progression.