MVA Vector Expression of SARS-CoV-2 Spike Protein and Protection of Adult Syrian Hamsters against SARS-CoV-2 Challenge

To evaluate the yield and immunogenicity of different forms of the viral spike (S) protein, scientists constructed modified vaccinia virus Ankara (MVA) vectors expressing full-length S, the RBD, and soluble S ectodomain and tested their immunogenicity in dose-ranging studies in mice.