Unlucky Punches: The Vulnerability-Stress Model for the Development of Impulse Control Disorders in Parkinson’s Disease

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The authors review current evidence for a vulnerability-stress model in which a relative reduction of dopaminergic projections to the ventral striatum and concomitant sensitization of postsynaptic neurons represent a predisposing (hypodopaminergic) vulnerability.
[npj Parkinson’s Disease]

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