The Candida albicans Toxin Candidalysin Mediates Distinct Epithelial Inflammatory Responses through p38 and EGFR-ERK Pathways

In cultured oral epithelial cells, candidalysin activated the MAPK p38, which resulted in heat shock protein 27 (Hsp27) activation, IL-6 release, and EGFR phosphorylation without affecting the induction of c-Fos.