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Chemical–Genetic Interaction Mapping Links Carbon Metabolism and Cell Wall Structure to Tuberculosis Drug Efficacy

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The authors utilized conditional Mycobacterium tuberculosis (Mtb) knockdown mutants of essential genes as an experimentally tractable surrogate for drug treatment and probed the relationship between Mtb carbon metabolism and chemical-genetic interactions
[Proceedings of the National Academy of Sciences of the United States of America]
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Abstract
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