Knockdown of fat mass and obesity-related protein (FTO) increased m6A methylation of TFPI-2 mRNA in pancreatic cancer (PC) cells, which increased mRNA stability via the m6A reader YTHDF1, resulting in up-regulation of TFPI-2 expression, and inhibited PC proliferation, colony formation, sphere formation, migration and invasion in vitro.
[Epigenetics]
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