Mettl14 ablation triggered apoptosis that depleted Lgr5+ stem cells and disrupted colonic organoid growth and differentiation, whereas the inhibition of apoptosis rescued Mettl14-deleted mice and organoids.
[Developmental Cell]
N6-Adenomethylation of GsdmC Is Essential for Lgr5+ Stem Cell Survival to Maintain Normal Colonic Epithelial Morphogenesis
