Neuroprotective Mechanism of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Improving the Phenotype Polarization of Microglia via the PI3K/AKT/Nrf2 Pathway in Vascular Dementia

Vascular dementia (VaD) rat model was established by bilateral common carotid artery ligation andhuman umbilical cord MSC derived extraellular vesicles (EVs) were extracted. VaD rats were injected with Evs through the tail vein.