Development and Functional Evaluation of MDR1-Expressing Microvascular Endothelial-Like Cells Derived from Human iPS Cells as an In Vitro Blood-Brain Barrier Model

To establish an in vitro model of the human blood-brain barrier, MDR1-overexpressing human induced pluripotent stem cells were generated, and were differentiated to MDR1-expressing brain microvascular endothelial-like cells.