Virological, Innate, and Adaptive Immune Profiles Shaped by Variation in Route and Age of Host in Murine Cytomegalovirus Infection

To assess the role of route and age at infection in modeling human cytomegalovirus in mice, scientists infected prepubescent and young sexually mature C57BL/6 mice intranasally, a likely physiological route in humans) and intraperitoneally, which is frequently used experimental route, and is possibly akin to transplant-mediated infection.