Nuclear-Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance

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Researchers showed that nuclear-localized branched-chain α-ketoacid dehydrogenase kinase (BCKDK) acts as a modulator of homologous recombination repair, promoting cell resistance against DNA damage-inducing therapy in breast cancer.
[Advanced Science]
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