Scientists clarified the role of KLHL38 in non-small cell lung cancer (NSCLC). KLHL38 expression was evaluated in tumor and adjacent normal tissues from 241 patients with NSCLC using immunohistochemistry and real-time PCR, and its association with clinicopathological parameters was analyzed.
[Cell Death & Disease]
7753456
HN7798IR
items
1
apa
0
default
asc
1
162969
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-2f79029ad4d9c57b542e8adfd14440e0%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22HN7798IR%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Xu%20et%20al.%22%2C%22parsedDate%22%3A%222021-05-28%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EXu%2C%20Y.%2C%20Wang%2C%20C.%2C%20Jiang%2C%20X.%2C%20Zhang%2C%20Y.%2C%20Su%2C%20H.%2C%20Jiang%2C%20J.%2C%20Ren%2C%20H.%2C%20%26amp%3B%20Qiu%2C%20X.%20%282021%29.%20KLHL38%20involvement%20in%20non-small%20cell%20lung%20cancer%20progression%20via%20activation%20of%20the%20Akt%20signaling%20pathway.%20%3Ci%3ECell%20Death%20%26amp%3B%20Disease%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%286%29%2C%201%26%23x2013%3B14.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41419-021-03835-0%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41419-021-03835-0%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3DHN7798IR%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22KLHL38%20involvement%20in%20non-small%20cell%20lung%20cancer%20progression%20via%20activation%20of%20the%20Akt%20signaling%20pathway%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yitong%22%2C%22lastName%22%3A%22Xu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chenglong%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xizi%22%2C%22lastName%22%3A%22Jiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yao%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hongbo%22%2C%22lastName%22%3A%22Su%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jun%22%2C%22lastName%22%3A%22Jiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hongjiu%22%2C%22lastName%22%3A%22Ren%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xueshan%22%2C%22lastName%22%3A%22Qiu%22%7D%5D%2C%22abstractNote%22%3A%22Lung%20cancer%20is%20the%20leading%20cause%20of%20cancer-related%20death%20worldwide.%20KLHL38%20has%20been%20reported%20to%20be%20upregulated%20during%20diapause%20but%20downregulated%20after%20androgen%20treatment%20during%20the%20reversal%20of%20androgen-dependent%20skeletal%20muscle%20atrophy.%20This%20study%20aimed%20to%20clarify%20the%20role%20of%20KLHL38%20in%20non-small%20cell%20lung%20cancer%20%28NSCLC%29.%20KLHL38%20expression%20was%20evaluated%20in%20tumor%20and%20adjacent%20normal%20tissues%20from%20241%20patients%20with%20NSCLC%20using%20immunohistochemistry%20and%20real-time%20PCR%2C%20and%20its%20association%20with%20clinicopathological%20parameters%20was%20analyzed.%20KLHL38%20levels%20positively%20correlated%20with%20tumor%20size%2C%20lymph%20node%20metastasis%2C%20and%20pathological%20tumor-node-metastasis%20stage%20%28all%20P%20%3C%200.001%29.%20In%20NSCLC%20cell%20lines%2C%20KLHL38%20overexpression%20promoted%20PTEN%20ubiquitination%2C%20thereby%20activating%20Akt%20signaling.%20It%20also%20promoted%20cell%20proliferation%2C%20migration%2C%20and%20invasion%20by%20upregulating%20the%20expression%20of%20genes%20encoding%20cyclin%20D1%2C%20cyclin%20B%2C%20c-myc%2C%20RhoA%2C%20and%20MMP9%2C%20while%20downregulating%20the%20expression%20of%20p21%20and%20E-cadherin.%20In%20vivo%20experiments%20in%20nude%20mice%20further%20confirmed%20that%20KLHL38%20promotes%20NSCLC%20progression%20through%20Akt%20signaling%20pathway%20activation.%20Together%2C%20these%20results%20indicate%20that%20KLHL38%20is%20a%20valuable%20candidate%20prognostic%20biomarker%20and%20potential%20therapeutic%20target%20for%20NSCLC.%22%2C%22date%22%3A%222021-05-28%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41419-021-03835-0%22%2C%22ISSN%22%3A%222041-4889%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41419-021-03835-0%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%2243ZBJFKZ%22%5D%2C%22dateModified%22%3A%222021-05-28T18%3A11%3A26Z%22%7D%7D%5D%7D
Xu, Y., Wang, C., Jiang, X., Zhang, Y., Su, H., Jiang, J., Ren, H., & Qiu, X. (2021). KLHL38 involvement in non-small cell lung cancer progression via activation of the Akt signaling pathway. Cell Death & Disease, 12(6), 1–14. https://doi.org/10.1038/s41419-021-03835-0 Cite
