Home Newsletters Immunology of Infectious Disease News Immunological Mechanisms of Vaccine-Induced Protection against COVID-19 in Humans

Immunological Mechanisms of Vaccine-Induced Protection against COVID-19 in Humans

0
dentifying the mechanisms of protection as well as correlates of protection is crucially important to inform further vaccine development and guide the use of licensed COVID-19 vaccines worldwide.
[Nature Reviews Immunology]
6445218 {6445218:KW6EZ4BS} apa 50 1 164220 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-4651bae08163663f05f33a04329e32d5%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22KW6EZ4BS%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Sadarangani%20et%20al.%22%2C%22parsedDate%22%3A%222021-07-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESadarangani%2C%20M.%2C%20Marchant%2C%20A.%2C%20%26amp%3B%20Kollmann%2C%20T.%20R.%20%282021%29.%20Immunological%20mechanisms%20of%20vaccine-induced%20protection%20against%20COVID-19%20in%20humans.%20%3Ci%3ENature%20Reviews%20Immunology%3C%5C%2Fi%3E%2C%201%26%23x2013%3B10.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41577-021-00578-z%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41577-021-00578-z%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DKW6EZ4BS%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Immunological%20mechanisms%20of%20vaccine-induced%20protection%20against%20COVID-19%20in%20humans%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manish%22%2C%22lastName%22%3A%22Sadarangani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Marchant%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tobias%20R.%22%2C%22lastName%22%3A%22Kollmann%22%7D%5D%2C%22abstractNote%22%3A%22Most%20COVID-19%20vaccines%20are%20designed%20to%20elicit%20immune%20responses%2C%20ideally%20neutralizing%20antibodies%20%28NAbs%29%2C%20against%20the%20SARS-CoV-2%20spike%20protein.%20Several%20vaccines%2C%20including%20mRNA%2C%20adenoviral-vectored%2C%20protein%20subunit%20and%20whole-cell%20inactivated%20virus%20vaccines%2C%20have%20now%20reported%20efficacy%20in%20phase%20III%20trials%20and%20have%20received%20emergency%20approval%20in%20many%20countries.%20The%20two%20mRNA%20vaccines%20approved%20to%20date%20show%20efficacy%20even%20after%20only%20one%20dose%2C%20when%20non-NAbs%20and%20moderate%20T%20helper%201%20cell%20responses%20are%20detectable%2C%20but%20almost%20no%20NAbs.%20After%20a%20single%20dose%2C%20the%20adenovirus%20vaccines%20elicit%20polyfunctional%20antibodies%20that%20are%20capable%20of%20mediating%20virus%20neutralization%20and%20of%20driving%20other%20antibody-dependent%20effector%20functions%2C%20as%20well%20as%20potent%20T%20cell%20responses.%20These%20data%20suggest%20that%20protection%20may%20require%20low%20levels%20of%20NAbs%20and%20might%20involve%20other%20immune%20effector%20mechanisms%20including%20non-NAbs%2C%20T%20cells%20and%20innate%20immune%20mechanisms.%20Identifying%20the%20mechanisms%20of%20protection%20as%20well%20as%20correlates%20of%20protection%20is%20crucially%20important%20to%20inform%20further%20vaccine%20development%20and%20guide%20the%20use%20of%20licensed%20COVID-19%20vaccines%20worldwide.%22%2C%22date%22%3A%222021-07-01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41577-021-00578-z%22%2C%22ISSN%22%3A%221474-1741%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41577-021-00578-z%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-07-05T21%3A31%3A18Z%22%7D%7D%5D%7D
Sadarangani, M., Marchant, A., & Kollmann, T. R. (2021). Immunological mechanisms of vaccine-induced protection against COVID-19 in humans. Nature Reviews Immunology, 1–10. https://doi.org/10.1038/s41577-021-00578-z Cite
Full Article
Exit mobile version