Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

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Dysfunctional Adipose Tissue-Lymphatic Crosstalk in Obesity

March 23, 2026

[Nature Reviews Endocrinology] The authors summarize the interconnected causes of obesity and lymphatic dysfunction with a particular focus on delineating the underappreciated yet fundamental crosstalk between the lymphatic network and white and brown adipose tissues.

Blood-Brain Barrier Disruption, Traumatic Encephalopathy, and Cognitive Decline in Retired Athletes

March 23, 2026

[Science Translational Medicine] Using dynamic contrast–enhanced magnetic resonance imaging, researchers showed that blood-brain barrier disruption can be detected years after the retirement of combat and collision sports athletes from their respective sports.

Single-Cell Multiomics Uncovers an Endothelial Mechanosensitive PIEZO1-IL-33 Axis Driving Pulmonary Fibrosis

March 23, 2026

[Nature Communications] Using integrated single-cell multi-omics profiling of human pulmonary fibrosis specimens and experimental fibrosis models induced by bleomycin or silica, scientists identified mechanosensitive Piezo1 upregulation in endothelial cells as a hallmark of fibrotic progression.

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

March 23, 2026

[Advanced Science] The authors established that endothelial G protein-coupled receptor 68 (GPR68) is a critical mediator of the inflammatory-remodeling program essential for arteriogenesis.

IRF6 Induces Endothelial Dysfunction through the Transcriptional Activation of NDRG1 and Aggravates Low Shear Stress-Mediated Atherosclerosis

March 23, 2026

[Iscience] In low-shear stress-treated human aortic endothelial cells (HAECs), Interferon regulatory factor 6 (IRF6) was also highly expressed. Inhibition of IRF6 reduces the expression of pro-inflammatory adhesion molecules and the adhesion of THP-1 cells to HAECs.

Elucidation of a Potent Pro-Resolving Mediator of Inflammation Resolution via Human Neutrophil-Vascular Endothelial Cell Interactions

March 23, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Given the intimate interactions between leukocytes and endothelial cells in inflammation resolution, researchers investigated whether unique bioactive molecules carrying pro-resolution properties are biosynthesized by human neutrophils coincubated with activated vascular endothelial cells.

ONL Therapeutics Announces First European Patient Randomized in its Global Phase 2 GALAXY Trial of Xelafaslatide (ONL1204) in Patients with Geographic Atrophy (GA) Associated...

March 23, 2026

[ONL Therapeutics, Inc.] ONL Therapeutics, Inc. announced that the first European participant has been randomized in the company’s Phase II GALAXY trial. GALAXY was designed to evaluate the efficacy and safety of xelafaslatide in patients with geographic atrophy associated with dry age-related macular degeneration.

Vietnamese Scientist Earns Prestigious Recognition in the US

March 23, 2026

[VietNamNet Global] The journey of Associate Professor Nguyen Duc Thanh is defined by groundbreaking biomedical research and a deep aspiration to bring advanced technologies closer to communities.

Hyperactive GNAQ in Endothelial Cells Causes Blood Vessel Malformation in Developing Mouse Skin

March 23, 2026

[Development] Researchers have shown that endothelial expression of GNAQ R183Q was sufficient to drive blood vessel malformation in developing mouse embryos.

PRMT5/Sohlh2/Sirt1 Signaling Pathway in Vascular Endothelial Cells Modulates Lung Metastasis of Triple-Negative Breast Cancer

March 23, 2026

[Advanced Science] Functional studies reveal that overexpression Sohlh2 in vascular endothelial cells (ECs) could repress the adhesion and trans-endothelial migration of triple negative breast cancer cells (TNBC), attenuate EC senescence, increased permeability, and inflammation induced by TNBC cells.

A Physiological Microfluidic Blood-Brain-Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation

March 23, 2026

[Advanced Healthcare Materials] To study the mechanisms underlying this phenomenon, researchers developed a microfluidic blood-brain barrier model using human cerebral microvascular endothelial cells in direct contact with primary human astrocytes and pericytes within a physiologically relevant extracellular matrix.

Untargeted Metabolomics Reveals the Effect of MYH9 on the Metabolism of Vascular Endothelial Cells

March 18, 2026

[iScience] Scientists discovered that inhibiting MYH9 or knocking down its gene significantly impairs angiogenesis, vasculogenesis and vascular endothelial cells functions including migration and tube formation.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.