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Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.
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FTO Promotes the Progression of Triple-Negative Breast Cancer by Regulating the M6a Methylation of NFKBIE
[Clinical and Experimental Medicine] The authors elucidated a novel mechanistic link between FTO and NFKBIE/MAPK signaling in TNBC pathogenesis, providing critical insights for future therapeutic strategies targeting this recalcitrant disease.
Identification and Analysis of Metabolic Reprogramming-Related Genes in Triple-Negative Breast Cancer
[Clinical and Experimental Medicine] Scientists identified specific genes associated with metabolic reprogramming in TNBC, which can potentially become unique biomarkers of this cancer.
IL-3/STAT5/Mir-155-5p Axis Supports Stem-Related Pathway Reprogramming in TNBC
[Breast Cancer Research] Researchers explored the IL-3 mechanism of action in TNBC and particular attention has been dedicated to investigating the impact of miR-155-5p in IL-3-mediated TNBC aggressiveness.
Orphan Nuclear Receptor 4A1 (NR4A1) and NR4A2 Are Endogenous Regulators of CD71 and Their Ligands Induce Ferroptosis in Breast Cancer
[Cell Death & Disease] Scientists hypothesize that NR4A1/2 may be important drug targets in TNBC due, in part, to their regulation of ferroptosis and key ferroptotic genes.
Anti-Progestin Therapy Targets Hallmarks of Breast Cancer Risk
[Nature] Researchers presented a template for biologically informed early-phase therapeutic cancer prevention trials and demonstrates the potential for premenopausal breast cancer prevention with progesterone receptor antagonists through stromal remodelling and luminal progenitor suppression.
Syantra and Alamo Breast Cancer Foundation Launch First-of-Its-Kind Partnership
[Syantra, Inc. (BioSpace)] Syantra, Inc. and Alamo Breast Cancer Foundation (ABCF) have formed a new partnership dedicated to innovative technology and increased access to detection and treatment.
Kean Professor Awarded Grant for Work on Breast Cancer Detection Via AI
[New Jersey Business Magazine] Dr. Meng Xu, an assistant professor in the Department of Computer Science and Technology at Kean University, has been awarded an AIM-AHEAD Research Fellowship Grant to support her work applying artificial inteligence to breast cancer detection.
Research Progress of DUB Enzyme in Breast Cancer
[Clinical and Experimental Medicine] The authors focus on several deubiquitinases associated with breast cancer, including their structure, function, and relationship to breast cancer.
Advances in the Intrinsic Signaling Pathway Interactions and Clinical Translation of HR+/HER2+ Breast Cancer
[Breast Cancer] Scientists highlight the molecular basis, treatment approaches, and emerging therapeutic strategies in HR+/HER2+ breast cancer, emphasizing the need for personalized and adaptive treatment strategies in managing this complex disease subtype.
DLL1-Responsive PD-L1 Tumor-Associated Macrophages Promote Endocrine Resistance in Breast Cancer
[Science Translational Medicine] The authors identified a subtype of immunosuppressive programmed death ligand 1–positive tumor-associated macrophages critically fostering resistance to tamoxifen and fulvestrant through maintaining cancer stem cell activity in new mouse models.
Pitavastatin Is a Novel Mcl-1 Inhibitor That Overcomes Paclitaxel Resistance in Triple-Negative Breast Cancer
[Experimental Hematology & Oncology] Researchers analyzed the impact of pitavastatin on TNBC cells was assessed in vitro by examining cell viability, apoptosis, mitochondrial function, and effects on cancer stem cell properties.
Genetic Regulation of the Estrogen Receptor and Inherited Predisposition to Breast Cancer
[Proceedings of the National Academy of Sciences of the United States of America] Scientists evaluated 136 families for coinheritance of breast cancer with each of 79 common variants reported as high-confidence “risk alleles” for breast cancer by meta-analyses of genome-wide association studies.
For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.
