Endothelial Cell News Volume 7.21 | Jun 20 2022

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    2022-06-20 | ENDOCN 7.21


    Endothelial Cell News by STEMCELL Technologies
    Vol. 7.21 – 20 June, 2022
    TOP STORY

    Meteorin-Like Promotes Heart Repair through Endothelial KIT Receptor Tyrosine Kinase

    The authors identified the monocyte- and macrophage-derived cytokine meteorin-like as a driver of postinfarction angiogenesis and high-affinity ligand for the stem cell factor receptor KIT receptor tyrosine kinase.
    [Science]

    AbstractPress Release

    Survey results on the insights and hurdles of CRISPR genome editing.
    PUBLICATIONSRanked by the impact factor of the journal

    Schizophrenia-Derived hiPSC Brain Microvascular Endothelial-Like Cells Show Impairments in Angiogenesis and Blood–Brain Barrier Function

    Scientists presented a functional characterization of Schizophrenia-derived brain microvascular endothelial-like cells, the counterpart of the neurovascular crosstalk, revealing an intrinsically defective blood–brain barrier phenotype.
    [Molecular Psychiatry]

    Abstract

    Differentiated Glioma Cell-Derived Fibromodulin Activates Integrin-Dependent Notch Signaling in Endothelial Cells to Promote Tumor Angiogenesis and Growth

    Proteomic analysis showed a higher abundance of the extracellular matrix small leucine-rich proteoglycan Fibromodulin in the conditioned medium of differentiated glioma cells, the equivalent of glioma non-cancer stem cells, compared to that of glioma stem-like cells.
    [eLife]

    Abstract

    ERG Activity Is Regulated by Endothelial FAK Coupling with TRIM25/USP9x in Vascular Patterning

    Researchers identified ECFAK as a regulator of retinal vascular patterning by controlling ERG protein degradation via TRIM25/USP9x.
    [Development]

    Abstract

    Inhibition of CD146 Lessens Uveal Melanoma Progression through Reducing Angiogenesis and Vasculogenic Mimicry

    Tube formation and migration of primary human retinal microvascular endothelial cells and tube-like structure formation, migration, invasion of uveal melanoma cells were evaluated after CD146 inhibition.
    [Cellular Oncology]

    Abstract

    Differential Contribution of NF-κB Signaling Pathways to CD4+ Memory T Cell Induced Activation of Endothelial Cells

    Investigators examined whether CD4+ memory T cells could drive endothelial cell inflammatory responses.
    [Frontiers in Immunology]

    Full Article

    Active RhoA Exerts an Inhibitory Effect on the Homeostasis and Angiogenic Capacity of Human Endothelial Cells

    The authors reported that expression of active and wild‐type RhoA but not dominant‐negative RhoA significantly inhibited endothelial cell proliferation, migration, tube formation, and angiogenic sprouting in vitro.
    [Journal of the American Heart Association]

    Full Article

    Breast Cancer Cells Mediate Endothelial Cell Activation, Promoting Von Willebrand Factor Release, Tumor Adhesion and Transendothelial Migration

    Researchers highlighted the significant crosstalk between tumor cells and the endothelium including increased von Willebrand Factor secretion which may have contributed to tumor metastasis.
    [Journal of Thrombosis and Haemostasis]

    Abstract

    The Mechanism by Which Crocetin Regulates the lncRNA NEAT1/miR-125b-5p/SOX7 Molecular Axis to Inhibit High Glucose-Induced Diabetic Retinopathy

    To explore the expression of NEAT1 and miR-125b-5p and the proliferation activity, migration ability, and angiogenesis ability of human retinal microvascular endothelial cells, RT-qPCR, CCK-8, Transwell, and tube formation assays were performed.
    [Experimental Eye Research]

    Abstract

    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    REVIEWS

    Flow Goes Forward and Cells Step Backward: Endothelial Migration

    Recent technical advances, such as precise cell fate mapping, time-lapse imaging, genome editing, and single-cell RNA sequencing, have shed new light on the role of venous endothelial cells in angiogenesis under both normal and pathological conditions.
    [Experimental & Molecular Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    Inozyme Pharma Announces Partnership with Rady Children’s Institute for Genomic Medicine to Advance Newborn Screening for Genetic Diseases

    Inozyme Pharma, Inc. announced a partnership with Rady Children’s Institute for Genomic Medicine to advance and evaluate a novel newborn screening technology to facilitate the diagnosis of genetic diseases.
    [Inozyme Pharma, Inc.]

    Press Release

    SoniVie Receives IDE Approval from FDA for Its Pilot Study to Treat Hypertension with Its Renal Artery Denervation TIVUS™ Technology

    SoniVie announced that the US FDA granted Investigational Device Exemption (IDE) approval for its “REDUCED1” Pilot study to treat resistant hypertension patients with renal artery denervation using TIVUS, its innovative ultra-sound ablation system.
    [SoniVie (Cision US, Inc.)]

    Press Release

    FEATURED EVENT

    Danish Stem Cell Society (DASCS) 2022

    September 19 – 20, 2022
    Vejle, Denmark

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Vascular Biology and Inflammation

    Aarhus University – Aarhus, Denmark

    Postdoctoral Position – Vascular Biology

    L’institut du Thorax Research Unit – Nantes, France

    Postdoctoral Scientist – Cardiovascular Systems

    University of California, San Diego – La Jolla, California, United States

    Postdoctoral Fellow – Neurovascular Research

    Huntington Medical Research Institutes – Pasadena, California, United States

    Postdoctoral Associate – Lung and Liver Injury in Sickle Cell Disease

    University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States

    > See All Jobs

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