Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

Targeting the CCL5/CCR5 Axis in Tumor-Stromal Crosstalk to Overcome Cisplatin Resistance in Neuroendocrine Prostate Cancer

October 29, 2025

[Journal of Experimental & Clinical Cancer Research] Scientists established a neuroendocrine prostate cancer mouse allograft model and performed RNA sequencing to identify genes associated with cisplatin resistance.

PFKFB3 As a Multifaceted Driver and Therapeutic Target in Castration-Resistant Prostate Cancer

October 28, 2025

[Cell Death & Disease] Researchers showed that PFKFB3, an essential regulator of glycolytic metabolism, is significantly upregulated in prostate cancer tissues and CRPC cell lines, where it plays a pivotal role in driving CRPC progression.

A microRNA CRISPR Screen Reveals microRNA-483-3p As an Apoptotic Regulator in Prostate Cancer Cells

October 28, 2025

[Cell Death & Disease] The authors developed miRKOv2, a miRNA-only CRISPR knockout library enabling systematic, genome-wide loss-of-function screens to identify miRNA essential for prostate cancer cell survival.

Telomir Pharmaceuticals Reports New Data Showing Telomir-1 Resets Cancer’s “Kill-and-Clean” Defense Systems in an Aggressive Prostate Cancer Model, Outperforming Rapamycin and Chemo

October 24, 2025

[Telomir Pharmaceuticals, Inc. ] Telomir Pharmaceuticals, Inc. reported new preclinical data from an in vivo study in mice bearing human aggressive prostate cancer tumors evaluating DNA-methylation changes in two key defense genes - CASP8 and GSTP1 - following treatment with oral Telomir-1, Rapamycin, chemotherapy, and combination regimens.

Prostate Cancer Foundation Honors Maha Hussain, MD, FACP, FASCO, Recipient of the First PCF Women in Science Lifetime Achievement Award

October 24, 2025

[PCF] The Prostate Cancer Foundation (PCF) announced the first-ever recipient of the PCF Women in Science Lifetime Achievement Award, Maha Hussain, MD, FACP, FASCO, the Genevieve Teuton Professor of Medicine at Northwestern University Feinberg School of Medicine.

ZDHHC2-Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation

October 24, 2025

[Advanced Science] Scientists developed a small-molecule ZDHHC2 inhibitor, TTZ1, which restores ACSL4 protein, reactivates ferroptosis, and reverses enzalutamide resistance in CRPC cell lines and patient-derived xenograft models.

Collagen-Binding IL-12-Armoured STEAP1 CAR-T Cells Reduce Toxicity and Treat Prostate Cancer in Mouse Models

October 24, 2025

[Nature Biomedical Engineering] Researchers showed that collagen-binding domain-fused IL-12 secreted from CAR-T cells to target human six transmembrane epithelial antigen of prostate 1 (STEAP1) is retained within murine prostate tumors.

ZC3H4, a Novel Regulator of Mitochondrial Complex I, Impacts Prostate Stromal Cell Senescence, Attachment, Adhesion, and Anoikis Resistance

October 22, 2025

[Cell Death & Disease] Investigators utilized glycolytic restriction and pharmacologic inhibition of the mitochondrial electron transfer chain complex I to promote mitochondrial dysfunction and identify the cellular processes impacted by declining mitochondrial function in benign prostate stromal cells.

Aggressive Prostate Cancer Is Associated with Pericyte Dysfunction

October 22, 2025

[Molecular Oncology] Analysis of human prostate cancer and murine models showed that prostate tumors exhibit a disequilibrium between endothelial and pericyte content with prognostic potential.

PACT Is Requisite for Prostate Cancer Cell Proliferation

October 22, 2025

[Scientific Reports] Scientists investigated the role of PACT in prostate cancer (PCa) using a loss-of-function approach. Depletion of PACT in multiple PCa cell lines results in a reduction in cell proliferation, but viability is maintained.

Protein Disulfide Isomerases Regulate Androgen Receptor Stability and Promote Prostate Cancer Cell Growth and Survival

October 21, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Scientists identified the protein disulfide isomerases (PDIs) PDIA1 and PDIA5, which play a critical role in folding of client proteins in the ER, as important regulators of prostate cancer growth and response to therapy.

Chromatin Remodeling Restrains Oncogenic Functions in Prostate Cancer

October 21, 2025

[Nature Communications] Investigators explored the epigenomic landscape of prostate tumor biopsies from 25 treatment-naïve male patients by analyzing chromatin compartmentalization patterns.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.