Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Necroptosis Triggers Inflammatory Interferon Signatures in Patient-Derived Metastatic Breast Cancer Organoids

June 9, 2026

[Signal Transduction and Targeted Therapy] Scientists applied 3D patient-derived, metastatic human mammary organoids to model apoptosis resistance, necroptosis, and inflammatory signaling using single-cell CITE-sequencing, time-lapse live cell brightfield, and immunofluorescent confocal microscopy, as well as biochemical approaches.

Commensal Dysbiosis Alters Primary Bile Acid Signaling to Drive Mammary Gland Inflammation and Breast Tumor Dissemination

June 9, 2026

[Cancer Research] Researchers revealed that commensal dysbiosis-associated loss of microbial bile acid (BA) metabolism elevates primary BAs and promotes HR+ metastatic progression through prostaglandin E2 signaling.

HTRA1+ Macrophages Induce T-Cell Egress through CRIP1/NF-κB/CXCL12 to Limit the Effects of Immunotherapy in Triple-Negative Breast Cancer

June 9, 2026

[Cancer Immunology Research] Using single-cell and spatial transcriptomes, investigators identified, at the single-cell level, a subpopulation of macrophages related to T cell expansion during immunotherapy, characterized by high expression of high-temperature requirement A1 (HTRA1), and correlated with clinical and immunotherapy outcomes in TNBC.

IRX1 Suppresses Breast Cancer Progression by Inhibiting Fatty Acid De Novo Synthesis through Downregulating ACACA Expression

June 9, 2026

[Cell Death & Disease] The authors demonstrated that iroquois homeobox 1 (IRX1) is downregulated in breast cancer tissues and cell lines due to promoter hypermethylation.

Red Blood Cell-Derived Extracellular Vesicles Enable Cisplatin and Cetuximab Combined Therapy against Triple-Negative Breast Cancer

June 9, 2026

[Journal of Nanobiotechnology] Scientists highlighted the potential of red blood cell-derived extracellular vesicles as a biocompatible delivery system enabling combined therapy and offering a promising strategy to overcome current limitations in TNBC treatment.

NSUN2/M5c/TPI1 Axis Promotes Glycolysis and Immune Evasion in Breast Cancer

June 9, 2026

[Journal of Translational Medicine] Researchers investigated the role of NSUN2 in breast cancer and the underlying mechanisms. They found that NSUN2 accelerates the progression of breast cancer by promoting glycolysis and immune evasion.

Ligand-Functionalized Liposomal Vesicles in Breast Cancer: Advances in Targeted Nanotherapeutics

June 9, 2026

[Expert Opinion on Drug Delivery] The authors discuss ligand-functionalized liposomes for active targeting in breast cancer. Surface modification with antibodies, peptides, aptamers, carbohydrates, and small molecules enables selective binding to overexpressed receptors, improving cellular uptake and intracellular drug delivery.

Mammogen Secures Up to $30 Million Series A Financing Backed by Leading US Public Retirement System to Advance Blood-Based RNA Breast Cancer Detection Platform

June 9, 2026

[Mammogen (Globe Newswire)] Mammogen announced an up to $30 million institutional Series A equity financing led by a major US public retirement system. The financing is structured to support Mammogen’s next phase of growth, including its pivotal prospective clinical program and commercialization expansion.

Inhibition of Histone Demethylase LSD1 Suppresses CD47 Expression and Enhances Efficacy of CD47 Blockade in Breast Cancer

June 5, 2026

[Journal for Immunotherapy of Cancer] Researchers investigated the crosstalk between the histone demethylase lysine-specific demethylase 1 (LSD1) and CD47 signaling in TNBC using in silico datasets, isogenic cell lines, conditional BRCA1 knockout models, and syngeneic mouse models.

Dectin-1 Signaling Promotes Galectin-3 Shedding and Expansion of Immunosuppressive CD71+ Erythroid Cells in Breast Cancer

June 5, 2026

[Oncoimmunology] Using murine models of TNBC, scientists investigated the therapeutic effects of curdlan, a β-glucan. They found that TNBC was associated with extramedullary erythropoiesis and expansion of CD71+ erythroid cells.

Cross-Kingdom Signals: Microbial, Metabolites, and Immune Cells on the Gut-Breast Axis

June 5, 2026

[Critical Reviews in Food Science and Nutrition] This review synthesizes cross-kingdom signals in the gut–breast axis and outlines translational opportunities—from dietary fiber and targeted postbiotics to bile-acid pathway modulation and antibiotic stewardship—to improve lactation health and inform oncology.

Targeting Arginine Metabolism Reverses Bone Immunosuppressive Microenvironment and Metastasis in ARID1A-Deficient Triple Negative Breast Cancer

May 27, 2026

[Nature Communications] Investigators showed that female patients with ARID1A‑mutated triple negative breast cancer exhibit a higher bone metastasis incidence.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.