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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
Exosomes from Liver Progenitor Cells Carrying JAG1 Activate Notch Signaling to Promote Liver Regeneration in PVL Rats
[Cell Death & Disease] Researchers demonstrated that exosomes from hypertrophic liver tissue can activate the YAP-Notch signaling pathway both in vitro and in vivo, thereby promoting liver regeneration after portal vein ligation.
MetaVia Announces AI-Driven Collaboration with Syntekabio to Explore Additional Indications for DA-1241
[MetaVia] MetaVia Inc. announced a research collaboration with Syntekabio, Inc. to identify additional disease targets and optimize the therapeutic profile of DA-1241, MetaVia's novel oral G-Protein-Coupled Receptor 119 agonist.
Regulatory Mechanisms of Hepatocyte PCSK9 Expression: Translating Mechanistic Insights into Potential Nutraceuticals
[Chinese Medicine] The authors explore the intricate regulatory network that controls hepatic proprotein convertase subtilisin/kexin type 9 (PCSK9) expression and explores how these molecular insights can be translated into nutraceutical applications.
Hepatocyte KCTD17-Mediated SERPINA3 Inhibition Determines Liver Fibrosis in Metabolic Dysfunction-Associated Steatohepatitis
[Experimental & Molecular Medicine] Researchers identified increased KCTD17 levels in patients with metabolic dysfunction-associated steatohepatitis (MASH), and in dietary rodent models of MASH which showed an inverse correlation with the expression of serine protease inhibitor a3k.
Kaempferol Inhibits Lipid Accumulation in Alcoholic Fatty Liver Disease through PRMT-1-Mediated Arginine Methylation of SCD1
[Journal of Antibiotics] Scientists investigated the effect and the mechanism of kaempferol on alcoholic fatty liver disease at the cellular level.
NOX1 Inhibition Sensitizes HCC Cells to Sorafenib and Radiotherapy by Modulating ROS-Mediated Programmed Cell Death
[Acta Pharmacologica Sinica] By comprehensive analysis of public databases and validation with in-house clinical specimens, researchers showed that NOX1 expression is significantly elevated in metastatic HCC that is correlated to poor patient prognosis.
Betaine-Homocysteine Methyltransferase Protects against Acetaminophen-Induced Acute Liver Failure via BACH1-SCD1-Oleic Acid Axis
[Acta Pharmacologica Sinica] The authors found that betaine-homocysteine methyltransferase, primarily expressed in hepatocytes, showed reduced expression in the liver but elevated serum levels in the acetaminophen-induced liver injury mouse model.
Hydronidone Alleviates Metabolic Dysfunction-Associated Fatty Liver Disease by Inhibiting CD36 Expression
[FASEB Journal] High fat and high cholesterol diet as well as methionine-choline deficient diet were used to establish the metabolic dysfunction-associated fatty liver disease mouse model.
Loss of Hepatocyte-Specific RECK Exacerbates Metabolic Dysfunction-Associated Steatohepatitis
[American Journal of Physiology-Endocrinology and Metabolism] Using two novel mouse models of hepatocyte-specific REversion Inducing Cysteine Rich Protein With Kazal Motifs (RECK) depletion, investigators demonstrated that RECK gene deletion significantly increased inflammation, ballooning, and fibrosis in the liver.
Inhibition of the Caveolin-1 Pathway Promotes Apoptosis and Overcomes Pan-Tyrosine Kinase Inhibitor Resistance in Hepatocellular Carcinoma
[Cell Death & Disease] Researchers used multiple tyrosine kinase inhibitors (TKI)-resistant HCC cell lines to identify caveolin-1 (CAV1) as a key driver of therapeutic resistance. CAV1 downregulation induces apoptosis, inhibits metastasis, and restores TKI sensitivity in both inherent and acquired TKI-resistant HCC cells.
Differential Expression Pattern of CC Chemokine Receptor 7 Guides Precision Treatment of Hepatocellular Carcinoma
[Signal Transduction and Targeted Therapy] Investigators highlight the opposing effects of tumor cell-derived versus stromal cell-derived CCR7 expression and guides the precision treatment for HCC.
AusperBio Receives China CDE Clearance to Advance AHB-137 into Phase III Clinical Trial for Chronic Hepatitis B
[AusperBio Therapeutics, Inc. (BioSpace)] AusperBio Therapeutics, Inc. and Ausper Biopharma Co., Ltd. (collectively AusperBio) announced that the China Center for Drug Evaluation has approved the initiation of a Phase III clinical trial for its lead candidate, AHB-137.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
