[Proceedings of the National Academy of Sciences of the United States of America] Researchers employed region-specific single-cell transcriptomics of the subventricular zone and ipsilesional peri-infarct territory in mice to identify a distinct subpopulation of GFAP+ FOXF2+ ependymal cells that selectively expand within the subventricular zoneafter neural injury.

[Nature Immunology] Using high-resolution spatiotemporal live imaging in zebrafish embryos, scientists identifed a distinct population of macrophages residing within blood vessels, termed blood vessel-resident macrophages, with conserved features in mice.

[Nature Reviews Nephrology] The kidney contains a heterogeneous population of endothelial cells including vascular, glomerular and lymphatic endothelia, each of which perform distinct functions related to kidney function, tissue homeostasis and inflammation.

[JCI Insight] Scientists identified downregulation of miR-93-5p specifically in glomerular endothelial cells in Alport syndrome along disease progression. Silencing of miR-93-5p in extracellular vesicles (EV) from human amniotic fluid stem cells changed the transcriptomic and proteomic profile, regulating EV disease-modifying activity.

[Hubrecht Institute] Drs. Jeroen den Hertog, Francesca Mattiroli, Jeroen Bakkers, and Eva van Rooij, group leaders at the Hubrecht Institute, have received ZonMw Open Competition grants. The grants allow them to delve deeper into their research on RASopathies and heart regeneration.

[Lineage Cell Therapeutics, Inc. (BioSpace)] Lineage Cell Therapeutics, Inc. announced the expansion of its cell transplant pipeline with the launch of COR1, a new corneal endothelial cell therapy program, in preclinical development for the treatment of corneal endothelial disease.

[Denali Therapeutics, Inc] Denali Therapeutics, Inc. announced the US FDA has granted accelerated approval for AVLAYAH™, the first FDA-approved biologic specifically designed to cross the blood-brain barrier and reach the whole body, including the brain.

[Advanced Science] Researchers identified disruptor of telomeric silencing 1-like (DOT1L), a histone H3 lysine 79 (H3K79) methyltransferase, as a key epigenetic regulator of endothelial-to-mesenchymal transition (EndoMT) and fibrotic progression.

[Advanced Healthcare Materials] Scientists developed a novel microphysiological syste that recapitulates the blind-ended microanatomy and fluid absorption properties of capillary lymphatics.

[Advanced Healthcare Materials] The authors presented a comprehensive overview of the current landscape of vascular graft development. Key fabrication strategies, such as 3D bioprinting and decellularization are discussed alongside surface modification approaches, including heparinization and endothelial cell seeding.

[Molecular Psychiatry] Researchers found that liver-derived C3 critically contributes to stress susceptibility and blood-brain barrier (BBB) impairment in the nucleus accumbens by inhibiting endothelial cell claudin-5, a pivotal tight junction protein for BBB integrity.

[Nature Communications] Using bulk RNA sequencing and single-cell RNA sequencing analyses, researchers identified KIF11 as a key downstream effector in retinal endothelial cells.