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Cell Therapy News
Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.
CAR-Macrophage Cell Therapy: A New Era of Hope for Pancreatic Cancer
[Clinical Cancer Research] Investigators highlight recent advances in CAR-macrophage therapy for solid tumors, with an emphasis on pancreatic ductal adenocarcinoma.
The Wistar Institute Receives $17 Million NIH Grant for Personalized HIV Cure Research
[The Wistar Institute (Globenewswire)] The Wistar Institute announces the National Institutes of Health granted a five-year, $17 million research award to launch iCure Consortium to develop individualized “cure regimens” for HIV.
Polyclonal Expansion of Functional Tumor-Reactive Lymphocytes Infiltrating Glioblastoma for Personalized Cell Therapy
[Nature Communications] Tumor-reactive tumor-infiltrating lymphocytes were isolated and enriched for CD137 expression from cavitron ultrasonic aspirator emulsions of 161 adult patients diagnosed with diffuse gliomas.
Safety and Efficacy of Autologous Humanized CD19 CAR-T Cell Therapy for Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma
[Bone Marrow Transplantation] Investigators conducted a clinical trial to determine the safety of humanized CD19-targeted CART for patients with relapsed/refractory B-cell non-Hodgkin lymphoma.
Impact of CAR T Cell Therapy on Thymus Size in Children and Young Adults with Acute Lymphoblastic Leukemia
[Scientific Reports] Scientists investigated thymus size changes after CAR T-cell therapy, explored the associated clinical conditions, and assessed survival differences of patients who underwent CAR T-cell therapy.
GD2-Targeting CAR T Cells in High-Risk Neuroblastoma: A Phase 1/Phase 2 Trial
[Nature Medicine] Antidisialoganglioside (GD2) have shown encouraging efficacy in children with high-risk metastatic, relapsed, or refractory neuroblastoma in a Phase I/Phase II clinical trial. Scientists presented the final results obtained in all patients enrolled with the same criteria of the trial and treated in a hospital exemption setting.
Gene Therapy Restores Auditory Function and Rescues Damaged Inner Hair Cells in an Aged Vglut3 Knockout Mouse Model
[Gene Therapy] The authors analyzed the cochlear structure of aged vesicular glutamate transporter 3 (Vglut3)KO mice, revealing significant degeneration of inner hair cells, synapses, and stereocilia.
Glycan Shielding Enables TCR-Sufficient Allogeneic CAR-T Therapy
[Cell] Investigators showed that signal peptide peptidase-like 3 (SPPL3) deletion enabled glycan-mediated immune evasion in primary T cells.
Control of Immune Response in an iPSC-Based Allogeneic Cell Therapy Clinical Trial for Parkinson’s Disease
[Cell Stem Cell] All patients were transplanted with dopaminergic neural progenitors differentiated from iPSCs, which had homozygous human leukocyte antigen haplotypes, through immunosuppression with tacrolimus alone.
Compact Polyethylenimine-Complexed mRNA Vaccines
[Nature Nanotechnology] The authors described formulations comprising individual, polymer-complexed self-amplifying RNA molecules, designed for vaccination against infectious diseases and other prophylactic and therapeutic applications.
Clinical and Molecular Dissection of CAR T Cell Resistance in Pancreatic Cancer
[Cell Reports Medicine] Investigators reported on a Phase I clinical trial assessing the safety and feasibility of intravenous and local administration of anti-mesothelin CAR T cells in patients with advanced pancreatic ductal adenocarcinoma.
Dual-Vector rAAVrh8 Gene Therapy for GM2 Gangliosidosis: A Phase I/II Trial
[Nature Medicine] Investigators initiated a Phase I/II, single-dose, dose-escalation of combined BiT, intra-cisterna magna and intrathecal infusion in children with Tay–Sachs and Sandhoff diseases
Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.
