Metabolomics to Understand Placental Biology: Where Are We Now?

The authors discuss the technical aspects of metabolomics and review the current literature describing the placental metabolome in human and animal models, in the context of health and disease.
[Tissue and Cell]
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Maternal Selenium Deficiency Suppresses Proliferation, Induces Autophagy Dysfunction, Apoptosis in the Placenta of Mice

Researchers found that maternal selenium (Se) deficiency decreased placental Se concentration and expressions of some antioxidant selenoproteins.
[Metallomics]
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Maternal and Infant Immune Repertoire Sequencing Analysis Identifies Distinct Ig and TCR Development in Term and Preterm Infant

Scientists analyzed lymphocyte receptor repertoires in maternal and cord blood from 14 term and 10 preterm deliveries, hypothesizing that the high prevalence of infection in patients with preterm labor may result in specific changes in the T cell and B cell repertoires.
[Journal of Immunology]
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The Treasury of Wharton’s Jelly

Scientists investigated very small embryonic-like cells (VSELs)-like cells in terms of their pluripotency phenotype and tri-lineage differentiation potential.
[Stem Cell Reviews and Reports]
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Preclinical Assessment of Thrombin-Preconditioned Human Wharton’s Jelly-Derived Mesenchymal Stem Cells for Neonatal Hypoxic-Ischaemic Brain Injury

The authors evaluated the tissue distribution and potential toxicity of thrombin-preconditioned human Wharton’s jelly-derived MSCs in animal models before the initiation of clinical trials.
[Journal of Cellular and Molecular Medicine]
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Longeveron Announces Activation of Two New Clinical Sites in ELPIS II Trial of Lomecel-B for Hypoplastic Left Heart Syndrome (HLHS)

Longeveron, Inc. announced the activation of two new clinical sites for the currently enrolling ELPIS II Trial, evaluating Lomecel-B injection into the myocardium of infants with Hypoplastic Left Heart Syndrome, a rare and life-threatening congenital heart defect.
[Longeveron, Inc.]
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Maternal SARS-CoV-2 Infection Elicits Sexually Dimorphic Placental Immune Responses

Investigators examined the intersection of maternal-fetal antibody transfer, viral-induced placental interferon responses, and fetal sex in pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
[Science Translational Medicine]
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DNA Barcode to Trace the Development and Differentiation of Cord Blood Stem Cells

The latest research findings on the development and differentiation, culture techniques and labeling and tracing of umbilical cord blood stem cells are reviewed.
[Molecular Medicine Reports]
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Development of Injectable Graphene Oxide/Laponite/Gelatin Hydrogel Containing Wharton’s Jelly Mesenchymal Stem Cells for Treatment of Oxidative Stress-Damaged Cardiomyocytes

Injectable GO/laponite/gelatin (GO-LG) hydrogel was developed and characterized. The results of cell viability showed that the optimal concentration of GO flasks to treat cells was 100 μg/ml.
[Colloids and Surfaces B-Biointerfaces]
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Extracellular Vesicles Secreted from Mesenchymal Stem Cells Exert Anti-Apoptotic and Anti-Inflammatory Effects via Transmitting microRNA-18b in Rats with Diabetic Retinopathy

Scientists investigated the anti-inflammatory properties of small extracellular vesicles derived from human umbilical cord MSCs in a diabetic rat model and human retinal microvascular endothelial cells.
[International Immunopharmacology]
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Dimethyl Sulfoxide-Free Cryopreservation Solutions for Hematopoietic Stem Cell Grafts

The authors compared the capacity of four dimethyl sulfoxide (DMSO)-free freezing media to cryopreserve cord blood HSCs: CryoProtectPureSTEM, CryoScarless, CryoNovo P24 and Pentaisomaltose. Clinical-grade DMSO/dextran solution was used as control.
[Cytotherapy]
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