Investigators found that human T cell leukemia virus type 1 proviral DNA was present in the placental villous tissues of the fetuses of nearly half of pregnant carriers and in a small number of cord blood samples.
[Journal of Clinical Investigation]
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Tezuka, K., Fuchi, N., Okuma, K., Tsukiyama, T., Miura, S., Hasegawa, Y., Nagata, A., Komatsu, N., Hasegawa, H., Sasaki, D., Sasaki, E., Mizukami, T., Kuramitsu, M., Matsuoka, S., Yanagihara, K., Miura, K., & Hamaguchi, I. (2020). HTLV-1 targets human placental trophoblasts in seropositive pregnant women. The Journal of Clinical Investigation, 130(11). https://doi.org/10.1172/JCI135525 Cite
Patients underwent treatment of full-thickness chondral injury in the osteoarthritic knee with high tibial osteotomy and implantation of human umbilical cord-MSCs and were followed prospectively for a minimum of one year.
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Chung, Y.-W., Yang, H.-Y., Kang, S.-J., Song, E.-K., & Seon, J.-K. (2020). Allogeneic umbilical cord blood-derived mesenchymal stem cells combined with high tibial osteotomy: a retrospective study on safety and early results. International Orthopaedics. https://doi.org/10.1007/s00264-020-04852-y Cite
Researchers tested the hypothesis that systemic AMP cell administration could suppress both optic neuritis and myelitis in amnion epithelial cells (EAE). Intravenous and intraperitoneal administration of AMP cells significantly reduced ascending paralysis and attenuated visual dysfunction in EAE mice.
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Using cord blood mononuclear cells and cord plasma isolated from infants born to women with a high BMI compared to women with a normal BMI, the authors evaluated differences in immune cell populations using single‐cell mass cytometry.
[American Journal of Reproductive Immunology]
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Enninga, E. A. L., Jang, J. S., Hur, B., Johnson, E. L., Wick, M. J., Sung, J., & Chakraborty, R. (n.d.). Maternal Obesity is Associated with Phenotypic Alterations in Fetal Immune Cells by Single-Cell Mass Cytometry. American Journal of Reproductive Immunology, n/a(n/a), e13358. https://doi.org/10.1111/aji.13358 Cite
Platelet lysate (PL) had been shown to induce chondrogenic differentiation of human umbilical cord‐derived MSCs Scientists investigated whether long non‐coding RNA H19 was involved in this process. Human umbilical cord MSCs were isolated, identified, and cultured in 5% PL‐supplemented chondrogenic differentiation medium
[Febs Open Bio]
Investigators focus on summarizing the biological characteristics of human amniotic epithelial cells, therapeutic applications, and recent advances in treating various tissue injuries and disorders.
[Stem Cell Research & Therapy]
Global Stem Cells Group (GSCG) has signed a historic agreement with a company known as Bioscience Cell Factor- this Dubai-based healthcare company will allow GSCG to act as their representatives operating in both the Middle East and Latin America.
[Global Stem Cells Group]
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Scientists performed whole-genome bisulfite sequencing of 152 umbilical cord blood samples from the MARBLES and EARLI high-familial risk prospective cohorts to identify an epigenomic signature of autism spectrum disorder at birth.
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Mordaunt, C. E., Jianu, J. M., Laufer, B. I., Zhu, Y., Hwang, H., Dunaway, K. W., Bakulski, K. M., Feinberg, J. I., Volk, H. E., Lyall, K., Croen, L. A., Newschaffer, C. J., Ozonoff, S., Hertz-Picciotto, I., Fallin, M. D., Schmidt, R. J., & LaSalle, J. M. (2020). Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes. Genome Medicine, 12(1), 88. https://doi.org/10.1186/s13073-020-00785-8 Cite
Umbilical cord-MSC culture was conducted under xeno- and serum-free conditions. Four patients with established bronchopulmonary dysplasia were enrolled in this study between May 25, 2018, and December 31, 2018.
[Journal of Translational Medicine]
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Nguyen, L. T., Trieu, T. T. H., Bui, H. T. H., Hoang, V. T., Nguyen, A. T. T., Trinh, N. T. H., Nguyen, K. T., & Hoang, D. M. (2020). Allogeneic administration of human umbilical cord-derived mesenchymal stem/stromal cells for bronchopulmonary dysplasia: preliminary outcomes in four Vietnamese infants. Journal of Translational Medicine, 18(1), 398. https://doi.org/10.1186/s12967-020-02568-6 Cite
Scientists investigated the effectiveness of hyaluronan–methylcellulose hydrogels loaded with Wharton’s Jelly-derived mesenchymal stromal cell in vitro and in a rat coccygeal Intervertebral disc degeneration model.
[International Journal of Molecular Sciences]
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Choi, U. Y., Joshi, H. P., Payne, S., Kim, K. T., Kyung, J. W., Choi, H., Cooke, M. J., Kwon, S. Y., Roh, E. J., Sohn, S., Shoichet, M. S., & Han, I. (2020). An Injectable Hyaluronan–Methylcellulose (HAMC) Hydrogel Combined with Wharton’s Jelly-Derived Mesenchymal Stromal Cells (WJ-MSCs) Promotes Degenerative Disc Repair. International Journal of Molecular Sciences, 21(19), 7391. https://doi.org/10.3390/ijms21197391 Cite
The structure of the rabbit umbilical cord was analyzed and compared with that of human umbilical macroscopically and histologically. Scientists isolated, cultured, and identified the proliferative activity and immunological characteristics of rabbit umbilical cord MSCs in vitro using mixed lymphocyte reaction, flow cytometry, and ELISA test.
[Journal of Gene Medicine]