FDA Gives Green Light for Multiple Sclerosis Stem Cell Trial

Non-profit research organization Hope Biosciences Stem Cell Research Foundation has received FDA authorization for a randomized, double-blind, single center, Phase II clinical trial to assess the efficacy of multiple intravenous infusions of autologous adipose-derived mesenchymal stem cells in improving symptoms and quality of life in patients with mild-to-moderate multiple sclerosis.
[Hope Biosciences Stem Cell Research Foundation (BusinessWire, Inc.)]
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Episomal Vector Reprogramming of Human Umbilical Cord Blood Natural Killer Cells to an Induced Pluripotent Stem Cell Line MUSIi013-A

Natural killer cells were isolated from human umbilical cord blood from a healthy newborn and reprogrammed by episomal vectors carrying reprograming factors L-MYC, LIN28, OCT4, SOX2, KLF4, EBNA-1, and shRNA against p53 delivered using nucleofection.
[Stem Cell Research]
Klaihmon, P., Luanpitpong, S., Lorthongpanich, C., Laowtammathron, C., Waeteekul, S., Terbto, P., & Issaragrisil, S. (2021). Episomal vector reprogramming of human umbilical cord blood natural killer cells to an induced pluripotent stem cell line MUSIi013-A. Stem Cell Research, 55, 102472. https://doi.org/10.1016/j.scr.2021.102472 Cite
Abstract
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Strongyloides stercoralis and HTLV-1 Coinfection in CD34+ Cord Blood Stem Cell Humanized Mice: Alteration of Cytokine Responses and Enhancement of Larval Growth

A model of HTLV-1 and S. stercoralis coinfection in CD34+ umbilical cord blood hematopoietic stem cell engrafted humanized mice was established.
[PLOS Neglected Tropical Diseases]
Springer, L. E., Patton, J. B., Zhan, T., Rabson, A. B., Lin, H.-C., Manser, T., Lok, J. B., Hess, J. A., & Abraham, D. (2021). Strongyloides stercoralis and HTLV-1 coinfection in CD34+ cord blood stem cell humanized mice: Alteration of cytokine responses and enhancement of larval growth. PLOS Neglected Tropical Diseases, 15(7), e0009559. https://doi.org/10.1371/journal.pntd.0009559 Cite
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Firefly Luciferase Offers Superior Performance to AkaLuc for Tracking the Fate of Administered Cell Therapies

Umbilical cord MSCs were transduced to produce two genetically engineered populations, expressing either AkaLuc or the engineered FLuc luc2.
[European Journal of Nuclear Medicine and Molecular Imaging]
Amadeo, F., Plagge, A., Chacko, A., Wilm, B., Hanson, V., Liptrott, N., Murray, P., & Taylor, A. (2021). Firefly luciferase offers superior performance to AkaLuc for tracking the fate of administered cell therapies. European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-021-05439-4 Cite
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Pregnancy and Pandemics: Interaction of Viral Surface Proteins and Placenta Cells

Scientists display information on Variola, Influenza, Zika and Corona viruses focused on their surface proteins, effects on pregnancy, and possible target placental cells.
[Biochimica et Biophysica Acta]
Fuentes-Zacarías, P., Murrieta-Coxca, J. M., Gutierrez-Samudio, R. N., Schmidt, A., Schmidt, A., Markert, U. R., & Morales-Prieto, D. M. (2021). Pregnancy and pandemics: Interaction of viral surface proteins and placenta cells. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 166218. https://doi.org/10.1016/j.bbadis.2021.166218 Cite
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CHIP-Overexpressing Wharton’s Jelly-Derived Mesenchymal Stem Cells Attenuate Hyperglycemia-Induced Oxidative Stress-Mediated Kidney Injuries in Diabetic Rats

Western blot analysis, flow cytometry, and MitoSOX staining revealed that hyperglycemia-induced mitochondrial oxidative stress production and apoptosis were attenuated in CHIP-overexpressing Wharton’s jelly-derived mesenchymal stem cells
[Free Radical Biology and Medicine]
Ali, A., Shibu, M. A., Kuo, C.-H., Lo, J.-F., Chen, R.-J., Day, C. H., Ho, T.-J., PadmaViswanadha, V., Kuo, W.-W., & Huang, C.-Y. (2021). CHIP-overexpressing Wharton’s jelly-derived mesenchymal stem cells attenuate hyperglycemia-induced oxidative stress-mediated kidney injuries in diabetic rats. Free Radical Biology and Medicine, 173, 70–80. https://doi.org/10.1016/j.freeradbiomed.2021.07.026 Cite
AbstractGraphical Abstract
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Mesenchymal Stem Cell-Derived Extracellular Vesicles as Probable Triggers of Radiation-Induced Heart Disease

Scientists examined the hypothesis that the altered secretion of extracellular vesicles from MSCs was the trigger of radiation-induced heart disease.
[Stem Cell Research & Therapy]
Luo, L., Yan, C., Fuchi, N., Kodama, Y., Zhang, X., Shinji, G., Miura, K., Sasaki, H., & Li, T.-S. (2021). Mesenchymal stem cell-derived extracellular vesicles as probable triggers of radiation-induced heart disease. Stem Cell Research & Therapy, 12(1), 422. https://doi.org/10.1186/s13287-021-02504-5 Cite
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Unresponsive Thin Endometrium Caused by Asherman Syndrome Treated with Umbilical Cord Mesenchymal Stem Cells on Collagen Scaffolds: A Pilot Study

Researchers evaluate the effect of transplantation with collagen scaffold/umbilical cord MSCs on Asherman syndrome.
[Stem Cell Research & Therapy]
Zhang, Y., Shi, L., Lin, X., Zhou, F., Xin, L., Xu, W., Yu, H., Li, J., Pan, M., Pan, Y., Dai, Y., Zhang, Y., Shen, J., Zhao, L., Lu, M., & Zhang, S. (2021). Unresponsive thin endometrium caused by Asherman syndrome treated with umbilical cord mesenchymal stem cells on collagen scaffolds: a pilot study. Stem Cell Research & Therapy, 12(1), 420. https://doi.org/10.1186/s13287-021-02499-z Cite
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hucMSC-Derived Exosomes Attenuate Colitis by Regulating Macrophage Pyroptosis via the miR-378a-5p/NLRP3 Axis

Human umbilical cord MSC-derived exosomes carrying miR-378a-5p inhibited NLRP3 inflammasomes and abrogated cell pyroptosis to protect against DSS-induced colitis.
[Stem Cell Research & Therapy]
Cai, X., Zhang, Z., Yuan, J., Ocansey, D. K. W., Tu, Q., Zhang, X., Qian, H., Xu, W., Qiu, W., & Mao, F. (2021). hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis. Stem Cell Research & Therapy, 12(1), 416. https://doi.org/10.1186/s13287-021-02492-6 Cite
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Cord Blood Group 2 Innate Lymphoid Cells Are Associated with Lung Function at Six Weeks of Age

Researchers investigated cord blood immune cell populations from babies born to mothers with asthma in pregnancy.
[Clinical & Translational Immunology]
Gomes, G. M. C., Belinelo, P. de G., Starkey, M. R., Murphy, V. E., Hansbro, P. M., Sly, P. D., Robinson, P. D., Karmaus, W., Gibson, P. G., Mattes, J., & Collison, A. M. (2021). Cord blood group 2 innate lymphoid cells are associated with lung function at 6 weeks of age. Clinical & Translational Immunology, 10(7), e1296. https://doi.org/10.1002/cti2.1296 Cite
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Lymphoid and Myeloid Immune Cell Reconstitution after Nicotinamide-Expanded Cord Blood Transplantation

Investigators evaluated the immune reconstitution of patients receiving omidubicel grafts during the first six months post-transplant, as IR is critical for favorable outcomes of the procedure.
[Bone Marrow Transplantation]
de Koning, C., Tao, W., Lacna, A., van Veghel, K., Horwitz, M. E., Sanz, G., Jagasia, M. H., Wagner, J. E., Stiff, P. J., Hanna, R., Cilloni, D., Valcárcel, D., Peled, T., Galamidi Cohen, E., Goshen, U., Pandit, A., Lindemans, C. A., Jan Boelens, J., & Nierkens, S. (2021). Lymphoid and myeloid immune cell reconstitution after nicotinamide-expanded cord blood transplantation. Bone Marrow Transplantation, 1–8. https://doi.org/10.1038/s41409-021-01417-4 Cite
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