HTLV-1 Targets Human Placental Trophoblasts in Seropositive Pregnant Women

Investigators found that human T cell leukemia virus type 1 proviral DNA was present in the placental villous tissues of the fetuses of nearly half of pregnant carriers and in a small number of cord blood samples.
[Journal of Clinical Investigation]
Tezuka, K., Fuchi, N., Okuma, K., Tsukiyama, T., Miura, S., Hasegawa, Y., Nagata, A., Komatsu, N., Hasegawa, H., Sasaki, D., Sasaki, E., Mizukami, T., Kuramitsu, M., Matsuoka, S., Yanagihara, K., Miura, K., & Hamaguchi, I. (2020). HTLV-1 targets human placental trophoblasts in seropositive pregnant women. The Journal of Clinical Investigation, 130(11). https://doi.org/10.1172/JCI135525 Cite
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Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cells Combined with High Tibial Osteotomy: A Retrospective Study on Safety and Early Results

Patients underwent treatment of full-thickness chondral injury in the osteoarthritic knee with high tibial osteotomy and implantation of human umbilical cord-MSCs and were followed prospectively for a minimum of one year.
[International Orthopaedics]
Chung, Y.-W., Yang, H.-Y., Kang, S.-J., Song, E.-K., & Seon, J.-K. (2020). Allogeneic umbilical cord blood-derived mesenchymal stem cells combined with high tibial osteotomy: a retrospective study on safety and early results. International Orthopaedics. https://doi.org/10.1007/s00264-020-04852-y Cite
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Amnion-Derived Multipotent Progenitor Cells Suppress Experimental Optic Neuritis and Myelitis

Researchers tested the hypothesis that systemic AMP cell administration could suppress both optic neuritis and myelitis in amnion epithelial cells (EAE). Intravenous and intraperitoneal administration of AMP cells significantly reduced ascending paralysis and attenuated visual dysfunction in EAE mice.
[Neurotherapeutics]
Khan, R. S., Ross, A. G., Willett, K., Dine, K., Banas, R., Brown, L. R., & Shindler, K. S. (2020). Amnion-Derived Multipotent Progenitor Cells Suppress Experimental Optic Neuritis and Myelitis. Neurotherapeutics. https://doi.org/10.1007/s13311-020-00949-9 Cite
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Maternal Obesity is Associated with Phenotypic Alterations in Fetal Immune Cells by Single‐Cell Mass Cytometry

Using cord blood mononuclear cells and cord plasma isolated from infants born to women with a high BMI compared to women with a normal BMI, the authors evaluated differences in immune cell populations using single‐cell mass cytometry.
[American Journal of Reproductive Immunology]
Enninga, E. A. L., Jang, J. S., Hur, B., Johnson, E. L., Wick, M. J., Sung, J., & Chakraborty, R. (n.d.). Maternal Obesity is Associated with Phenotypic Alterations in Fetal Immune Cells by Single-Cell Mass Cytometry. American Journal of Reproductive Immunology, n/a(n/a), e13358. https://doi.org/10.1111/aji.13358 Cite
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Platelet Lysate Induces Chondrogenic Differentiation of Umbilical Cord-Derived Mesenchymal Stem Cells by Regulating the lncRNA H19/miR-29b-3p/SOX9 Axis

Platelet lysate (PL) had been shown to induce chondrogenic differentiation of human umbilical cord‐derived MSCs Scientists investigated whether long non‐coding RNA H19 was involved in this process. Human umbilical cord MSCs were isolated, identified, and cultured in 5% PL‐supplemented chondrogenic differentiation medium
[Febs Open Bio]
Cao, B., & Dai, X. (n.d.). Platelet lysate induces chondrogenic differentiation of umbilical cord-derived mesenchymal stem cells by regulating the lncRNA H19/miR-29b-3p/SOX9 axis. FEBS Open Bio, n/a(n/a). https://doi.org/10.1002/2211-5463.13002 Cite
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Application of Human Amniotic Epithelial Cells in Regenerative Medicine: A Systematic Review

Investigators focus on summarizing the biological characteristics of human amniotic epithelial cells, therapeutic applications, and recent advances in treating various tissue injuries and disorders.
[Stem Cell Research & Therapy]
Zhang, Q., & Lai, D. (2020). Application of human amniotic epithelial cells in regenerative medicine: a systematic review. Stem Cell Research & Therapy, 11(1), 439. https://doi.org/10.1186/s13287-020-01951-w Cite
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Global Stem Cells Group Announces Partnership with Bioscience Cell Factory

Global Stem Cells Group (GSCG) has signed a historic agreement with a company known as Bioscience Cell Factor- this Dubai-based healthcare company will allow GSCG to act as their representatives operating in both the Middle East and Latin America.
[Global Stem Cells Group]
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Cord Blood DNA Methylome in Newborns Later Diagnosed with Autism Spectrum Disorder Reflects Early Dysregulation of Neurodevelopmental and X-linked Genes

Scientists performed whole-genome bisulfite sequencing of 152 umbilical cord blood samples from the MARBLES and EARLI high-familial risk prospective cohorts to identify an epigenomic signature of autism spectrum disorder at birth.
[Genome Medicine]
Mordaunt, C. E., Jianu, J. M., Laufer, B. I., Zhu, Y., Hwang, H., Dunaway, K. W., Bakulski, K. M., Feinberg, J. I., Volk, H. E., Lyall, K., Croen, L. A., Newschaffer, C. J., Ozonoff, S., Hertz-Picciotto, I., Fallin, M. D., Schmidt, R. J., & LaSalle, J. M. (2020). Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes. Genome Medicine, 12(1), 88. https://doi.org/10.1186/s13073-020-00785-8 Cite
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Allogeneic Administration of Human Umbilical Cord-Derived Mesenchymal Stem/Stromal Cells for Bronchopulmonary Dysplasia: Preliminary Outcomes in Four Vietnamese Infants

Umbilical cord-MSC culture was conducted under xeno- and serum-free conditions. Four patients with established bronchopulmonary dysplasia were enrolled in this study between May 25, 2018, and December 31, 2018.
[Journal of Translational Medicine]
Nguyen, L. T., Trieu, T. T. H., Bui, H. T. H., Hoang, V. T., Nguyen, A. T. T., Trinh, N. T. H., Nguyen, K. T., & Hoang, D. M. (2020). Allogeneic administration of human umbilical cord-derived mesenchymal stem/stromal cells for bronchopulmonary dysplasia: preliminary outcomes in four Vietnamese infants. Journal of Translational Medicine, 18(1), 398. https://doi.org/10.1186/s12967-020-02568-6 Cite
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An Injectable Hyaluronan–Methylcellulose (HAMC) Hydrogel Combined with Wharton’s Jelly-Derived Mesenchymal Stromal Cells (WJ-MSCs) Promotes Degenerative Disc Repair

Scientists investigated the effectiveness of hyaluronan–methylcellulose hydrogels loaded with Wharton’s Jelly-derived mesenchymal stromal cell in vitro and in a rat coccygeal Intervertebral disc degeneration model.
[International Journal of Molecular Sciences]
Choi, U. Y., Joshi, H. P., Payne, S., Kim, K. T., Kyung, J. W., Choi, H., Cooke, M. J., Kwon, S. Y., Roh, E. J., Sohn, S., Shoichet, M. S., & Han, I. (2020). An Injectable Hyaluronan–Methylcellulose (HAMC) Hydrogel Combined with Wharton’s Jelly-Derived Mesenchymal Stromal Cells (WJ-MSCs) Promotes Degenerative Disc Repair. International Journal of Molecular Sciences, 21(19), 7391. https://doi.org/10.3390/ijms21197391 Cite
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Rabbit Umbilical Cord Mesenchymal Stem Cells: A New Option for Tissue Engineering

The structure of the rabbit umbilical cord was analyzed and compared with that of human umbilical macroscopically and histologically. Scientists isolated, cultured, and identified the proliferative activity and immunological characteristics of rabbit umbilical cord MSCs in vitro using mixed lymphocyte reaction, flow cytometry, and ELISA test.
[Journal of Gene Medicine]
Li, K.-D., Wang, Y., Sun, Q., Li, M.-S., Chen, J.-L., & Liu, L. (n.d.). Rabbit umbilical cord mesenchymal stem cells: A New Option for tissue engineering. The Journal of Gene Medicine, n/a(n/a), e3282. https://doi.org/10.1002/jgm.3282 Cite
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