Scientists summarize the results of preclinical and clinical studies dealing with the introduction of epithelial and mesenchymal stem cells of the afterbirth origin to the liver failure therapy.
[Stem Cell Reviews and Reports]
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Patients were randomly assigned to receive a single dose of intrathecal ex vivo-expanded Wharton’s jelly-MSCs from human umbilical cord or placebo and were then switched to the other arm at six months.
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Albu, S., Kumru, H., Coll, R., Vives, J., Vallés, M., Benito-Penalva, J., Rodríguez, L., Codinach, M., Hernández, J., Navarro, X., & Vidal, J. (2020). Clinical effects of intrathecal administration of expanded Wharton jelly mesenchymal stromal cells in patients with chronic complete spinal cord injury: a randomized controlled study. Cytotherapy, 0(0). https://doi.org/10.1016/j.jcyt.2020.08.008 Cite
Investigators used tandem mass tag labeling technology followed by tandem mass spectrometry to compare the peptidomic profile of preterm and term umbilical cord MSC conditioned medium.
[Stem Cell Research & Therapy]
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Wang, Y., Zhang, L., Wu, Y., Zhu, R., Wang, Y., Cao, Y., Long, W., Ji, C., Wang, H., & You, L. (2020). Peptidome analysis of umbilical cord mesenchymal stem cell (hUC-MSC) conditioned medium from preterm and term infants. Stem Cell Research & Therapy, 11(1), 414. https://doi.org/10.1186/s13287-020-01931-0 Cite
Scientists provide a comprehensive overview on the progression of clinical trials for retinal degeneration treatment using four types of stem/progenitor cell-based transplantation to replace degenerative retinal cells and/or to supplement trophic factors from the aspects of safety, effectiveness and their respective advantages and disadvantages.
[Cell Death & Disease]
Investigators showed that a phosphorylation of threonine-107 in the Glyoxalase 1 protein, mediated by Ca2+/calmodulin-dependent kinase II delta, is associated with elevated catalytic efficiency of Glo1.
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Morgenstern, J., Katz, S., Krebs-Haupenthal, J., Chen, J., Saadatmand, A., Cortizo, F. G., Moraru, A., Zemva, J., Campos, M. C., Teleman, A., Backs, J., Nawroth, P., & Fleming, T. (2020). Phosphorylation of T107 by CamKIIδ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1. Cell Reports, 32(12). https://doi.org/10.1016/j.celrep.2020.108160 Cite
Adenoviral vectors carrying genes encoding vascular endothelial growth factor, glial cell-derived neurotrophic factor and neural cell adhesion molecule or gene engineered umbilical cord blood mononuclear cells overexpressing recombinant vascular endothelial growth factor, glial cell-derived neurotrophic factor, and neural cell adhesion molecule were intrathecally injected before distal occlusion of the middle cerebral artery in rats.
[International Journal of Molecular Sciences]
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Markosyan, V., Safiullov, Z., Izmailov, A., Fadeev, F., Sokolov, M., Kuznetsov, M., Trofimov, D., Kim, E., Kundakchyan, G., Gibadullin, A., Salafutdinov, I., Nurullin, L., Bashirov, F., & Islamov, R. (2020). Preventive Triple Gene Therapy Reduces the Negative Consequences of Ischemia-Induced Brain Injury after Modelling Stroke in a Rat. International Journal of Molecular Sciences, 21(18), 6858. https://doi.org/10.3390/ijms21186858 Cite
The authors investigated the benefit of the association of human umbilical cord MSCs with lodenafil, a phosphodiesterase-5 inhibitor, in an animal model of pulmonary arterial hypertension.
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Silva, M. de M. C. da, Alencar, A. K. N. de, Silva, J. S. da, Montagnoli, T. L., Silva, G. F. da, Rocha, B. de S., Montes, G. C., Mendez-Otero, R., Pimentel-Coelho, P. M., Vasques, J. F., Trahez, M. M., Sudo, R. T., & Zapata-Sudo, G. (2020). Therapeutic Benefit of the Association of Lodenafil with Mesenchymal Stem Cells on Hypoxia-induced Pulmonary Hypertension in Rats. Cells, 9(9), 2120. https://doi.org/10.3390/cells9092120 Cite
Scientists report cord blood transplantation outcomes of 97 children with Hurler syndrome after a busulfan pharmacokinetic targeted myeloablative conditioning regimens from 2004 to 2016.
[Biology of Blood and Marrow Transplantation]
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Lum, S. H., Orchard, P. J., Lund, T. C., Miller, W. P., Boelens, J. J., & Wynn, R. (2020). Outcome after a cord blood transplantation using busulfan pharmacokinetic targeted myeloablative conditioning for Hurler syndrome. Biology of Blood and Marrow Transplantation, 0(0). https://doi.org/10.1016/j.bbmt.2020.08.033 Cite
Researchers investigated the mechanism by which ibrutinib induces thrombocytopenia using cord blood CD34+ hematopoietic stem cells, a human megakaryoblastic cell line, and C57BL/6 mice.
[Thrombosis and Haemostasis]
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Huang, J., Huang, S., Ma, Z., Lin, X., Li, X., Huang, X., Wang, J., Ye, W., Li, Y., He, D., Yang, M., Pan, J., Ling, Q., Li, F., Mao, S., Wang, H., Wang, Y., & Jin, J. (2020). Ibrutinib Suppresses Early Megakaryopoiesis but Enhances Proplatelet Formation. Thrombosis and Haemostasis. https://doi.org/10.1055/s-0040-1716530 Cite
The Medical Research Council (MRC) and the Japan Agency for Medical Research and Development (AMED) have joined forces to support eight new Regenerative Medicine research partnerships. In this landmark collaboration, MRC and AMED will make a total of almost £7 million available to support collaborative projects that seek to advance regenerative approaches towards clinical use.
[Medical Research Council]
Researchers showed that a single human aorta-gonad-mesonephros region hematopoietic stem cell (HSC) could generate 600–1,600 functional daughter HSCs.
[Stem Cell Reports]
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Vast Self-Renewal Potential of Human AGM Region HSCs Dramatically Declines in the Umbilical Cord Blood: Stem Cell Reports. (n.d.). Retrieved September 18, 2020, from https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(20)30339-8 Cite