Successful Gene Therapy of Diamond-Blackfan Anemia in a Mouse Model and Human CD34+ Cord Blood Hematopoietic Stem Cells Using a Clinically Applicable Lentiviral Vector

Scientists demonstrated the efficacy and safety of using a clinically applicable lentiviral vector for the successful treatment of Rps19-deficient DBA in a mouse model and in human primary CD34+ cord blood cells.
[Haematologica]
Liu, Y., Dahl, M., Debnath, S., Rothe, M., Smith, E. M., Grahn, T. H. M., Warsi, S., Chen, J., Flygare, J., Schambach, A., & Karlsson, S. (2020). Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34+ cord blood hematopoietic stem cells using a clinically applicable lentiviral vector. Haematologica. https://doi.org/10.3324/haematol.2020.269142 Cite
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Successful Gene Therapy of Diamond-Blackfan Anemia in a Mouse Model and Human CD34+ Cord Blood Hematopoietic Stem Cells Using a Clinically Applicable Lentiviral Vector

Researchers observed that transduced ribosomal protein S19 (Rps19)-deficient bone marrow cells could reconstitute mice longterm and rescue the bone marrow failure and severe anemia observed in Rps19-deficient mice, with a low risk of mutagenesis and a highly polyclonal insertion site pattern.
[Haematologica]
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RheinCell Therapeutics Achieves Milestone GMP Certification to Manufacture Cord Blood-Derived iPSCs for Safe and Compliant Cell Therapies

RheinCell Therapeutics GmbH announced it has received Good Manufacturing Practice certification and Manufacturing Authorization. This marks a landmark achievement for RheinCell, which is now among a select few iPSCs manufacturers to have received the critical certification.
[Lifescience Newswire]
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Impact of Placental Malaria on Maternal, Placental and Fetal Cord Responses and Its Role in Pregnancy Outcomes in Women from Blue Nile State, Sudan

Malaria infection in the collected maternal peripheral, placental, umbilical cord samples was determined microscopically, and ELISA was used to measure the plasma levels IL-4, IL-6, IL-10, IL-17A, and INF γ in the collected positive and negative malaria samples.
[Malaria Journal]
Omer, S., Franco-Jarava, C., Noureldien, A., Omer, M., Abdelrahim, M., Molina, I., & Adam, I. (2021). Impact of placental malaria on maternal, placental and fetal cord responses and its role in pregnancy outcomes in women from Blue Nile State, Sudan. Malaria Journal, 20(1), 35. https://doi.org/10.1186/s12936-021-03580-x Cite
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Great Expectations: Induced Pluripotent Stem Cell Technologies in Neurodevelopmental Impairments

Investigators introduce the development of induced pluripotent stem cells (iPSCs), the currently established iPSCs disease models, and artificial organoids related to neurodevelopmental impairments.
[International Journal of Medical Sciences]
Zhang, X., Li, Z., Liu, Y., & Gai, Z. (2021). Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments. International Journal of Medical Sciences, 18(2), 459–473. https://doi.org/10.7150/ijms.51842 Cite
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Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Ameliorate Airway Inflammation in a Rat Model of Chronic Obstructive Pulmonary Disease (COPD)

The authors assessed the potential anti-inflammatory effects of human umbilical cord MSC-derived extracellular vesicles in a rat model of chronic obstructive pulmonary disease.
[Stem Cell Research & Therapy]
Ridzuan, N., Zakaria, N., Widera, D., Sheard, J., Morimoto, M., Kiyokawa, H., Mohd Isa, S. A., Chatar Singh, G. K., Then, K.-Y., Ooi, G.-C., & Yahaya, B. H. (2021). Human umbilical cord mesenchymal stem cell-derived extracellular vesicles ameliorate airway inflammation in a rat model of chronic obstructive pulmonary disease (COPD). Stem Cell Research & Therapy, 12(1), 54. https://doi.org/10.1186/s13287-020-02088-6 Cite
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Amniotic Fluid-Derived Multipotent Stromal Cells Drive Diabetic Wound Healing through Modulation of Macrophages

Researchers obtained third trimester amniotic fluid from term cesarean delivery and isolated and expanded MSCs in vitro. They then generated 10 mm wounds in Leprdb/db diabetic mouse skin, and splinted them open to allow for humanized wound modeling.
[Journal of Translational Medicine]
Subhan, B. S., Kwong, J., Kuhn, J. F., Monas, A., Sharma, S., & Rabbani, P. S. (2021). Amniotic fluid-derived multipotent stromal cells drive diabetic wound healing through modulation of macrophages. Journal of Translational Medicine, 19(1), 16. https://doi.org/10.1186/s12967-020-02674-5 Cite
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Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomal miR-27b Attenuates Subretinal Fibrosis via Suppressing Epithelial–Mesenchymal Transition by Targeting HOXC6

Human umbilical cord-derived mesenchymal stem cells were successfully cultured and identified, and exosomes were isolated from the supernatant by ultracentrifugation.
[Stem Cell Research & Therapy]
Li, D., Zhang, J., Liu, Z., Gong, Y., & Zheng, Z. (2021). Human umbilical cord mesenchymal stem cell-derived exosomal miR-27b attenuates subretinal fibrosis via suppressing epithelial–mesenchymal transition by targeting HOXC6. Stem Cell Research & Therapy, 12(1), 24. https://doi.org/10.1186/s13287-020-02064-0 Cite
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Perinatal Gram-Positive Bacteria Exposure Elicits Distinct Cytokine Responses In Vitro

The authors stimulated freshly isolated umbilical blood mononuclear cells with lysates of E. faecalis, S. agalacticae, and S. aureus collected from pregnant women in preterm labor.
[International Journal of Molecular Sciences]
Reuschel, E., Toelge, M., Haeusler, S., Deml, L., Seelbach-Goebel, B., & Solano, M. E. (2021). Perinatal Gram-Positive Bacteria Exposure Elicits Distinct Cytokine Responses In Vitro. International Journal of Molecular Sciences, 22(1), 332. https://doi.org/10.3390/ijms22010332 Cite
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Single-Cell Transcriptome Analysis of Uncultured Human Umbilical Cord Mesenchymal Stem Cells

Scientists investigated freshly isolated, uncultured umbilical cord (UC)-MSCs by single-cell RNA sequencing and found two populations of UC-MSCs.
[Stem Cell Research & Therapy]
Zhang, S., Wang, J. Y., Li, B., Yin, F., & Liu, H. (2021). Single-cell transcriptome analysis of uncultured human umbilical cord mesenchymal stem cells. Stem Cell Research & Therapy, 12(1), 25. https://doi.org/10.1186/s13287-020-02055-1 Cite
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Feasibility of Reduced-Dose Posttransplant Cyclophosphamide and Cotransplantation of Peripheral Blood Stem Cells and Umbilical Cord-Derived Mesenchymal Stem Cells for SAA

Scientists evaluated the effectiveness and safety of reduced-dose cyclophosphamide, 20 mg/kg for 13 patients in matched sibling donor hematopoietic stem cell transplantation (HSCT) cohort and 25 mg/kg for 22 patients in haplo-HSCT cohort, on days +3, +4 combined with cotransplantation of peripheral blood stem cells and human umbilical cord-derived MSCs for severe aplastic anemia (SAA).
[Scientific Reports]
Zu, Y., Zhou, J., Fu, Y., Fang, B., Liu, X., Zhang, Y., Yu, F., Zuo, W., Zhou, H., Gui, R., Li, Z., Liu, Y., Zhao, H., Zhang, C., & Song, Y. (2021). Feasibility of reduced-dose posttransplant cyclophosphamide and cotransplantation of peripheral blood stem cells and umbilical cord-derived mesenchymal stem cells for SAA. Scientific Reports, 11(1), 253. https://doi.org/10.1038/s41598-020-80531-7 Cite
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