HucMSC Exosomes Promoted Imatinib-Induced Apoptosis in K562-R Cells via a miR-145a-5p/USP6/GLS1 Axis

Administration of human umbilical cord MSC exosomes promoted imatinib-induced cell apoptosis through miR-145a-5p/USP6.
[Cell Death & Disease]
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Human Placental Mesenchymal Stromal Cells Are Ciliated and Their Ciliation Is Compromised in Preeclampsia

Scientists determined whether hCV-MSCs are ciliated and whether altered ciliation is responsible for defective hCV-MSCs in preeclamptic placentas, as the primary cilium is a hub for signal transduction, which is important for various cellular activities.
[BMC Medicine]
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Long Non-coding RNA ZEB2-AS1 Augments Activity of Trophoblast Cells and Prevents the Development of Recurrent Spontaneous Abortion in Mice through EZH2-Mediated CST3 Inhibition

Scientists explored the effect of abnormally expressed long non-coding RNA ZEB2-AS1 on the occurrence of recurrent spontaneous abortion.
[Reproductive Sciences]
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Isolation and Culture of Decidual Natural Killer Cells from Term Placenta and Complete Hydatidiform Mole

A novel protocol was developed to isolate and culture decidual natural killer cells cells from fresh, term placentas and complete hydatidiform moles.
[Journal of Reproductive Immunology]
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On-Going Consequences of In Utero Exposure of Pb: An Epigenetic Perspective

The authors review currently available information on lead (Pb)-mediated alterations in the fetal epigenome is summarized.
[Journal of Applied Toxicology]
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Celularity Receives Fast Track Designation from US FDA for Its NK Cell Therapy CYNK-101 in Development for the First-Line Treatment of Advanced HER2/Neu Positive Gastric and Gastroesophageal Junction Cancers

Celularity Inc. announced the US FDA has granted Fast Track Designation for its genetically modified cryopreserved human placental hematopoietic stem cell-derived natural killer (NK) cell therapy, CYNK-101, which is being developed in combination with standard chemotherapy, trastuzumab and pembrolizumab in patients in first-line locally advanced unresectable or metastatic HER2/neu positive gastric or gastroesophageal junction (G/GEJ) adenocarcinoma.
[Celularity, Inc.]
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Targeted Newborn Metabolomics: Prediction of Gestational Age from Cord Blood

Researchers determined whether metabolites from a retrospective collection of banked cord blood specimens could accurately estimate gestational age and validated these findings in cord blood samples from Busia, Uganda.
[Journal of Perinatology]
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Targeted Newborn Metabolomics: Prediction of Gestational Age from Cord Blood

Scientists determined whether metabolites from a retrospective collection of banked cord blood specimens could accurately estimate gestational age and validated these findings in cord blood samples from Busia, Uganda.
[Journal of Perinatology]
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Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation

The authors cross-compared transcriptomic and proteomic data and selected 26 candidate genes with the same expression trends in both omics analyses.
[Stem Cell Reviews and Reports]
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Impact of Reduced Uterine Perfusion Pressure Model of Preeclampsia on Metabolism of Placenta, Maternal and Fetal Hearts

Researchers examined the impact of the reduced uterine perfusion pressure rat model of preeclampsia on the maternal cardiovascular system, placental and fetal heart metabolism.
[Scientific Reports]
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Identification of Differentially Methylated Genes in First-Trimester Placentas with Trisomy 16

Trisomy 16 is the most common aneuploidy in first-trimester miscarriages. Scientists identified changes in DNA methylation in chorionic villi of miscarriages with trisomy 16.
[Scientific Reports]
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