Umbilical Cord Blood Metabolomics: Association with Intrauterine Hyperglycemia

Scientists explored differences in metabolites and metabolic pathways between individuals with hyperglycemia or well-controlled gestational diabetes mellitus and healthy controls.
[Pediatric Research]
Ma, J., Luo, J., He, M., Bian, X., Li, J., Du, Y., Sun, B., & Chen, H. (2021). Umbilical cord blood metabolomics: association with intrauterine hyperglycemia. Pediatric Research, 1–6. https://doi.org/10.1038/s41390-021-01516-4 Cite
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Identification and Characterization of Maternal Perivascular SUSD2+ Placental Mesenchymal Stem/Stromal Cells

Perivascular placental MSCs were isolated from the maternal placenta using SUSD2 magnetic bead sorting and assessed for the colony-forming unit-fibroblasts, surface markers, and in vitro differentiation into mesodermal lineages.
[Cell and Tissue Research]
Khanmohammadi, M., Mukherjee, S., Darzi, S., Paul, K., Werkmeister, J. A., Cousins, F. L., & Gargett, C. E. (2021). Identification and characterisation of maternal perivascular SUSD2+ placental mesenchymal stem/stromal cells. Cell and Tissue Research. https://doi.org/10.1007/s00441-021-03453-4 Cite
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POSTN Promotes the Proliferation of Spermatogonial Cells by Activating the Wnt/β-Catenin Signaling Pathway

Investigators found that CM secreted by human amniotic mesenchymal stem cells could enhance the proliferation capacity of mouse GC-1 spg cells.
[Reproductive Sciences]
Li, C., Cheng, D., Xu, P., Nie, H., Zhang, T., & Pang, X. (2021). POSTN Promotes the Proliferation of Spermatogonial Cells by Activating the Wnt/β-Catenin Signaling Pathway. Reproductive Sciences. https://doi.org/10.1007/s43032-021-00596-1 Cite
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Umbilical Mesenchymal Stem Cell-Derived Extracellular Vesicles as Enzyme Delivery Vehicle to Treat Morquio a Fibroblasts

Researchers cultured human umbilical mesenchymal stem cells (UMSCs), demonstrated presence of GALNS enzyme activity within the extracellular vesicles (EVs) derived from these UMSC, and study how these secreted EVs were taken up by GALNS-deficient cells and used by the deficient cell’s lysosomes.
[Stem Cell Research & Therapy]
Flanagan, M., Pathak, I., Gan, Q., Winter, L., Emnet, R., Akel, S., & Montaño, A. M. (2021). Umbilical mesenchymal stem cell-derived extracellular vesicles as enzyme delivery vehicle to treat Morquio A fibroblasts. Stem Cell Research & Therapy, 12(1), 276. https://doi.org/10.1186/s13287-021-02355-0 Cite
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Type 2 and Type 3 Innate Lymphoid Cells at the Maternal-Fetal Interface: Implications in Preterm Birth

Researchers analyzed the relative frequencies of innate lymphoid cells subsets in pregnancy and the levels of IL-4, IL-17, IL-22, and IFN-γ as inflammatory mediators.
[BMC Immunology]
Mendes, J., Rodrigues-Santos, P., Areia, A. L., Almeida, J.-S., Alves, V., Santos-Rosa, M., & Mota-Pinto, A. (2021). Type 2 and type 3 innate lymphoid cells at the maternal-fetal interface: implications in preterm birth. BMC Immunology, 22(1), 28. https://doi.org/10.1186/s12865-021-00423-x Cite
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Sox9 and Rbpj Differentially Regulate Endothelial to Mesenchymal Transition and Wound Scarring in Murine Endovascular Progenitors

Skin wound analysis from Sox9 conditional knock-out mice demonstrates a significant reduction in pathological EndMT resulting in reduced scar area. The converse was observed with Rbpj conditionally knocked-out from the murine vasculature or inhibition of Notch signaling in human endothelial colony forming cells, resulting in enhanced Sox9 and EndMT related gene
[Nature Communications]
Zhao, J., Patel, J., Kaur, S., Sim, S.-L., Wong, H. Y., Styke, C., Hogan, I., Kahler, S., Hamilton, H., Wadlow, R., Dight, J., Hashemi, G., Sormani, L., Roy, E., Yoder, M. C., Francois, M., & Khosrotehrani, K. (2021). Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors. Nature Communications, 12(1), 2564. https://doi.org/10.1038/s41467-021-22717-9 Cite
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Mesenchymal Stem Cells for Cardiac Regeneration: from Differentiation to Cell Delivery

Scientists focus on the strategies used to derive cardiomyocytes-like cells from MSCs isolated from three widely used tissue sources and their differentiation efficiencies.
[Stem Cell Reviews and Reports]
Gupta, S., Sharma, A., S, A., & Verma, R. S. (2021). Mesenchymal Stem Cells for Cardiac Regeneration: from Differentiation to Cell Delivery. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-021-10168-0 Cite
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Bioprinting of Human Cord Blood-Derived CD34+ Cells and Exploration of the Multilineage Differentiation Ability In Vitro

Scientists fabricated coaxial extruded core–shell tubular scaffolds and extrusion-based bioprinted cell-laden mesh scaffolds to mimic the functional niche in vitro.
[ACS Biomaterials Science & Engineering]
Chen, L., Zhou, D., Li, X., Yang, B., & Xu, T. (2021). Bioprinting of Human Cord Blood-Derived CD34+ Cells and Exploration of the Multilineage Differentiation Ability in Vitro. ACS Biomaterials Science & Engineering. https://doi.org/10.1021/acsbiomaterials.0c01297 Cite
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Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing through MiR-17-5p-mediated Enhancement of Angiogenesis

Researchers investigated the effects of extracellular vehicles secreted by human umbilical cord mesenchymal stem cells on angiogenesis under high glucose conditions in vivo and in vitro and to explore the underlying mechanisms.
[Stem Cell Reviews and Reports]
Wei, Q., Wang, Y., Ma, K., Li, Q., Li, B., Hu, W., Fu, X., & Zhang, C. (2021). Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing Through MiR-17-5p-mediated Enhancement of Angiogenesis. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-021-10176-0 Cite
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Allogeneic Hematopoietic Cell Transplantation with Cord Blood versus Mismatched Unrelated Donor with Post-transplant Cyclophosphamide in Acute Myeloid Leukemia

Scientists compared the allogeneic hematopoietic cell transplantation (allo-HCT) outcomes of cord blood transplantation versus single-allele-mismatched mismatched unrelated donor allo-HCT with post-transplant cyclophosphamide in acute myeloid leukemia.
[Journal of Hematology & Oncology]
Dholaria, B., Labopin, M., Sanz, J., Ruggeri, A., Cornelissen, J., Labussière-Wallet, H., Blaise, D., Forcade, E., Chevallier, P., Grassi, A., Zubarovskaya, L., Kuball, J., Ceballos, P., Ciceri, F., Baron, F., Savani, B. N., Nagler, A., & Mohty, M. (2021). Allogeneic hematopoietic cell transplantation with cord blood versus mismatched unrelated donor with post-transplant cyclophosphamide in acute myeloid leukemia. Journal of Hematology & Oncology, 14(1), 76. https://doi.org/10.1186/s13045-021-01086-2 Cite
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Human Acellular Amniotic Membrane Incorporating Exosomes from Adipose-Derived Mesenchymal Stem Cells Promotes Diabetic Wound Healing

ADSC-derived exosomes enhanced the proliferation and migration of human dermal fibroblasts and promoted proliferation and tube formation of human umbilical vein endothelial cells in vitro.
[Stem Cell Research & Therapy]
Xiao, S., Xiao, C., Miao, Y., Wang, J., Chen, R., Fan, Z., & Hu, Z. (2021). Human acellular amniotic membrane incorporating exosomes from adipose-derived mesenchymal stem cells promotes diabetic wound healing. Stem Cell Research & Therapy, 12(1), 255. https://doi.org/10.1186/s13287-021-02333-6 Cite
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