Insights into Intrauterine Growth Restriction Based on Maternal and Umbilical Cord Blood Metabolomics

Untargeted nuclear magnetic resonance metabolomics was applied in 84 umbilical cord blood and maternal blood samples obtained from 48 intrauterine growth restriction and 36 appropriate for gestational age deliveries.
[Scientific Reports]
Moros, G., Boutsikou, T., Fotakis, C., Iliodromiti, Z., Sokou, R., Katsila, T., Xanthos, T., Iacovidou, N., & Zoumpoulakis, P. (2021). Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics. Scientific Reports, 11(1), 7824. https://doi.org/10.1038/s41598-021-87323-7 Cite
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Imbalance between Inflammatory and Regulatory Cord Blood B Cells Following Pre-Term Birth

Researchers concluded that, after pre-term birth onset, a shift from immunoregulation towards inflammation takes place in cord blood cells that were reportedly representative of the fetal compartment.
[Journal of Reproductive Immunology]
Busse, M., Redlich, A., Hartig, R., Costa, S.-D., Rathert, H., Fest, S., & Zenclussen, A. C. (2021). Imbalance between inflammatory and regulatory cord blood B cells following pre-term birth. Journal of Reproductive Immunology, 103319. https://doi.org/10.1016/j.jri.2021.103319 Cite
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Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells

The authors found that p65 was activated during cellular senescence and inflammatory activation in human umbilical cord-derived MSCs.
[International Journal of Molecular Sciences]
Mato-Basalo, R., Morente-López, M., Arntz, O. J., van de Loo, F. A. J., Fafián-Labora, J., & Arufe, M. C. (2021). Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells. International Journal of Molecular Sciences, 22(7), 3367. https://doi.org/10.3390/ijms22073367 Cite
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Mesenchymal Stem Cells for the Compassionate Treatment of Severe Acute Respiratory Distress Syndrome Due to COVID 19

Scientists evaluated the safety and describe the clinical changes after IV administration of allogeneic human umbilical cord MSCs, in patients with bilateral pneumonia caused by COVID-19, complicated with severe acute respiratory distress syndrome, as compassionate treatment.
[Aging and Disease]
Iglesias Martin, B. P., & Iglesias Martin, B. P. (2021). Mesenchymal Stem Cells for the Compassionate Treatment of Severe Acute Respiratory Distress Syndrome Due to COVID 19. Aging and Disease, 12(2), 360–370. https://doi.org/10.14336/AD.2020.1218 Cite
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Transplantation of Human Amniotic Epithelial Cells Promotes Morphological and Functional Regeneration in a Rat Uterine Scar Model

Investigators investigated whether human amniotic epithelial cells transplantation has the therapeutic effects on the rat uterine scar following full-thickness injury.
[Stem Cell Research & Therapy]
Fan, Y., Sun, J., Zhang, Q., & Lai, D. (2021). Transplantation of human amniotic epithelial cells promotes morphological and functional regeneration in a rat uterine scar model. Stem Cell Research & Therapy, 12(1), 207. https://doi.org/10.1186/s13287-021-02260-6 Cite
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Effect of Long-Term 3D Spheroid Culture on WJ-MSC

Investigators developed a protocol enabling a derivation of MSC subpopulation with increased expression of pluripotent and neural genes.
[Cells]
Kaminska, A., Wedzinska, A., Kot, M., & Sarnowska, A. (2021). Effect of Long-Term 3D Spheroid Culture on WJ-MSC. Cells, 10(4), 719. https://doi.org/10.3390/cells10040719 Cite
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Systemic Administration of Mesenchymal Stem Cells Loaded with a Novel Oncolytic Adenovirus Carrying IL-24/Endostatin Enhances Glioma Therapy

Investigators developed an all-in-one Tet-on system that could regulate replication of oncolytic adenovirus.
[Cancer Letters]
Zhang, J., Chen, H., Chen, C., Liu, H., He, Y., Zhao, J., Yang, P., Mao, Q., & Xia, H. (2021). Systemic administration of mesenchymal stem cells loaded with a novel oncolytic adenovirus carrying IL-24/endostatin enhances glioma therapy. Cancer Letters. https://doi.org/10.1016/j.canlet.2021.03.027 Cite
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The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?

The authors disscuss evidence on the ability of perinatal cells to inhibit B cell proliferation, impair B cell differentiation, and promote regulatory B cell formation.
[International Journal of Molecular Sciences]
Magatti, M., Masserdotti, A., Cargnoni, A., Papait, A., Stefani, F. R., Silini, A. R., & Parolini, O. (2021). The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy? International Journal of Molecular Sciences, 22(7), 3405. https://doi.org/10.3390/ijms22073405 Cite
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Assessment of the Neuroprotective and Stemness Properties of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells under Variable (5% vs. 21%) Aerobic Conditions

Scientists investigated ten different properties of these cells cultured under 21% and 5% oxygen concentrations.
[Cells]
Tomecka, E., Lech, W., Zychowicz, M., Sarnowska, A., Murzyn, M., Oldak, T., Domanska-Janik, K., Buzanska, L., & Rozwadowska, N. (2021). Assessment of the Neuroprotective and Stemness Properties of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells under Variable (5% vs. 21%) Aerobic Conditions. Cells, 10(4), 717. https://doi.org/10.3390/cells10040717 Cite
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Intrabone Infusion for Allogeneic Umbilical Cord Blood Transplantation in Children

Investigators conducted a Phase I-II single arm, exploratory clinical trial from 2012 to 2016 in a single center. 15 patients aged from 1.9 to 16.4 years received an intrabone umbilical cord blood transplantation.
[Bone Marrow Transplantation]
Vairy, S., Louis, I., Vachon, M.-F., Richer, J., Teira, P., Cellot, S., Villeneuve, E., Haddad, E., Duval, M., & Bittencourt, H. (2021). Intrabone infusion for allogeneic umbilical cord blood transplantation in children. Bone Marrow Transplantation, 1–7. https://doi.org/10.1038/s41409-021-01275-0 Cite
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Eradication of Specific Donor-Dependent Variations of Mesenchymal Stem Cells in Immunomodulation to Enhance Therapeutic Values

Researchers analyzed human umbilical-cord-derived MSCs from 32 donors and revealed donor-dependent variations in two non-correlated properties; cell proliferation, and immune modulatory functions in vitro and in vivo, which might explain inconsistent clinical efficacies of MSCs.
[Cell Death & Disease]
Zhang, C., Zhou, L., Wang, Z., Gao, W., Chen, W., Zhang, H., Jing, B., Zhu, X., Chen, L., Zheng, C., Shi, K., Wu, L., Cheng, L., Zhang, K., & Sun, Y. E. (2021). Eradication of specific donor-dependent variations of mesenchymal stem cells in immunomodulation to enhance therapeutic values. Cell Death & Disease, 12(4), 1–11. https://doi.org/10.1038/s41419-021-03644-5 Cite
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