Cord Blood Maternal Microchimerism Following Unrelated Cord Blood Transplantation

Scientists employed a technique of highly sensitive HLA-specific quantitative-PCR assays targeting polymorphisms unique to the cord blood (CB) mother to assay CB-maternal microchimerism (MMc) in patients post-CB transplantation. After additional exclusion criteria, CB-MMc was evaluated at multiple timepoints in 36 patients
[Bone Marrow Transplantation]
Kanaan, S. B., Delaney, C., Milano, F., Scaradavou, A., Besien, K. van, Allen, J., Lambert, N. C., Cousin, E., Thur, L. A., Kahn, E., Forsyth, A. M., Sensoy, O., & Nelson, J. L. (2020). Cord blood maternal microchimerism following unrelated cord blood transplantation. Bone Marrow Transplantation, 1–9. https://doi.org/10.1038/s41409-020-01149-x Cite
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Logistics of an Advanced Therapy Medicinal Product during COVID-19 Pandemic in Italy: Successful Delivery of Mesenchymal Stromal Cells in Dry Ice

Researchers assessed effects of the transition from liquid nitrogen to dry ice on cell viability; apoptosis; phenotype; proliferation; immunomodulation; and clonogenesis; and validated dry ice-based transport of umbilical cord-MSCs to clinics.
[Journal of Translational Medicine]
Astori, G., Bernardi, M., Bozza, A., Catanzaro, D., Chieregato, K., Merlo, A., Santimaria, M., Barbazza, R., Amodeo, G., Ciccocioppo, R., Elice, F., & Ruggeri, M. (2020). Logistics of an advanced therapy medicinal product during COVID-19 pandemic in Italy: successful delivery of mesenchymal stromal cells in dry ice. Journal of Translational Medicine, 18(1), 451. https://doi.org/10.1186/s12967-020-02625-0 Cite
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MiR-196b-5p Inhibits Proliferation of Wharton’s Jelly Umbilical Cord Stem Cells

Scientists report that overexpression of miR‐196b‐5p in Wharton’s jelly MSCs (WJCMSCs) suppressed proliferation and arrested the cell cycle in G0/G1 phase, whereas knock‐down of miR‐196b‐5p promotes WJCMSC proliferation and cell cycle progression.
[Febs Open Bio]
Han, X., Yang, H., Liu, H., Zhang, C., Cao, Y., Fan, Z., & Shi, R. (n.d.). MiR-196b-5p inhibits proliferation of Wharton’s jelly umbilical cord stem cells. FEBS Open Bio, n/a(n/a). https://doi.org/https://doi.org/10.1002/2211-5463.13043 Cite
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Safety and Feasibility of Umbilical Cord Mesenchymal Stem Cells in Patients with COVID-19 Pneumonia: A Pilot Study

Researchers conducted a small sample, single arm, pilot trial. In addition to standard therapy, they performed four rounds of transplantation of umbilical cell‐MSCs in sixteen patients with severe and critically severe COVID‐19.
[Cell Proliferation]
Feng, Y., Huang, J., Wu, J., Xu, Y., Chen, B., Jiang, L., Xiang, H., Peng, Z., & Wang, X. (n.d.). Safety and feasibility of umbilical cord mesenchymal stem cells in patients with COVID-19 pneumonia: A pilot study. Cell Proliferation, n/a(n/a), e12947. https://doi.org/https://doi.org/10.1111/cpr.12947 Cite
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Preclinical Characterization and In Vivo Imaging of 111In-Labeled Mesenchymal Stem Cell-Derived Extracellular Vesicles

Wharton’s jelly-MSC-extracellylar vesicles (EVs) were isolated using Exo-Prep kit followed by characterization of expressing markers and size. After labeled by 111In-oxine, 111In-EVs were injected into C57BL/6 mice followed by μSPECT/CT imaging. Organs were then taken out for ex vivo biodistribution analysis.
[Molecular Imaging and Biology]
Lu, C.-H., Chen, Y.-A., Ke, C.-C., Chiu, S.-J., Chen, C.-C., Hsieh, Y.-J., Yang, B.-H., & Liu, R.-S. (2020). Preclinical Characterization and In Vivo Imaging of 111In-Labeled Mesenchymal Stem Cell–Derived Extracellular Vesicles. Molecular Imaging and Biology. https://doi.org/10.1007/s11307-020-01562-0 Cite
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Therapeutic Efficacy of Umbilical Cord-Derived Stem Cells for Diabetes Mellitus: A Meta-Analysis Study

The clinical efficacy was evaluated based on glycemic control status and β cell function, as well as the daily insulin requirement in diabetic patients after receiving umbilical cord-derived stem cell-transplantation compared to baseline values.
[Stem Cell Research & Therapy]
Kassem, D. H., & Kamal, M. M. (2020). Therapeutic efficacy of umbilical cord-derived stem cells for diabetes mellitus: a meta-analysis study. Stem Cell Research & Therapy, 11(1), 484. https://doi.org/10.1186/s13287-020-01996-x Cite
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Microenvironmental Changes Induced by Placenta-Derived Mesenchymal Stem Cells Restore Ovarian Function in Ovariectomized Rats via Activation of the PI3K-FOXO3 Pathway

Blood and ovary tissue were collected and analyzed after various placenta -derived (PD)-MSC transplantation treatments in an ovariectomized rat model. Changes in the expression of folliculogenesis- and ovary regeneration-related genes induced by PD-MSC treatments were analyzed by qRT-PCR, Western blotting, and histological analysis.
[Stem Cell Research & Therapy]
Choi, J. H., Seok, J., Lim, S. M., Kim, T. H., & Kim, G. J. (2020). Microenvironmental changes induced by placenta-derived mesenchymal stem cells restore ovarian function in ovariectomized rats via activation of the PI3K-FOXO3 pathway. Stem Cell Research & Therapy, 11(1), 486. https://doi.org/10.1186/s13287-020-02002-0 Cite
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Umbilical Cord Blood Cells for the Treatment of Preterm White Matter Injury: Potential Effects and Treatment Options

Investigators summarize pre-term white matter injury pathogenesis and pathophysiology, and the specific properties of different cell types in umbilical cord blood.
[Journal of Neuroscience Research]
Qiu, H., Qian, T., Wu, T., Wang, X., Zhu, C., Chen, C., & Wang, L. (n.d.). Umbilical cord blood cells for the treatment of preterm white matter injury: Potential effects and treatment options. Journal of Neuroscience Research, n/a(n/a). https://doi.org/https://doi.org/10.1002/jnr.24751 Cite
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Lonza and Be The Match BioTherapies Partner to Expand Vein-to-Vein Cell and Gene Therapy Supply Chain Network

Be The Match BioTherapies as a preferred partner to provide consistent access to high-quality, healthy donor tissue and cell and gene therapy supply chain support.
[Be The Match BioTherapies]
Press Release
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Recovery of Human Embryonic Stem Cells-Derived Neural Progenitors Exposed to Hypoxic-Ischemic-Reperfusion Injury by Indirect Exposure to Wharton’s Jelly Mesenchymal Stem Cells Through Phosphatidyl-inositol-3-Kinase Pathway

Cellular deregulation was assessed by measuring glutathione levels, basal calcium and intracellular calcium response under KCl stimulation, as well as the key parameters of proliferation, glial progenitor marker expression and migration.
[Cellular and Molecular Neurobiology]
Sowmithra, S., Jain, N. K., Bhonde, R., & Datta, I. (2020). Recovery of Human Embryonic Stem Cells-Derived Neural Progenitors Exposed to Hypoxic-Ischemic-Reperfusion Injury by Indirect Exposure to Wharton’s Jelly Mesenchymal Stem Cells Through Phosphatidyl-inositol-3-Kinase Pathway. Cellular and Molecular Neurobiology. https://doi.org/10.1007/s10571-020-01007-w Cite
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Interleukin-8 Receptors CXCR1 and CXCR2 Are Not Expressed by Endothelial Colony-Forming Cells

CXCR1 and CXCR2 were not detected on several clones of cord blood- endothelial colony-forming cell using different antibodies available, in contrast to well-known positive cells.
[Stem Cell Reviews and Reports]
Blandinières, A., Hong, X., Philippe, A., Bièche, I., Vacher, S., Rossi, E., Detriche, G., Gendron, N., Gaussem, P., Guerin, C. L., Melero-Martin, J. M., & Smadja, D. M. (2020). Interleukin-8 Receptors CXCR1 and CXCR2 Are Not Expressed by Endothelial Colony-forming Cells. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10081-y Cite
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