FDA Approves Study to Investigate the Use of Cell Therapy to Treat COVID-19 Related Multisystem Inflammatory Syndrome in Children (MIS-C)

The Cura Foundation in collaboration with The Marcus Foundation, Sanford Health and Alliance for Cell Therapy Now, is supporting a clinical trial of human cord tissue mesenchymal stromal cells to treat children with Multisystem Inflammatory Syndrome in Children.
[Alliance for Cell Therapy Now (PR Newswire Association LLC.)]
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Successful Cord Blood Transplantation for Myelodysplastic Syndrome Complicated by Mycobacterium Kansasii Pneumonia

Investigators report a case of myelodysplastic syndrome treated by umbilical cord blood transplantation after Mycobacterium kansasii pneumonia.
[Transplant Infectious Disease]
Yamada, A., Akahane, D., Katagiri, S., Yoshizawa, S., Furuya, N., Fujimoto, H., Gotoh, M., & Gotoh, A. (n.d.). Successful cord blood transplantation for myelodysplastic syndrome complicated by Mycobacterium kansasii pneumonia. Transplant Infectious Disease, n/a(n/a), e13463. https://doi.org/10.1111/tid.13463 Cite
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TNFSF15 Facilitates Human Umbilical Cord Blood Hematopoietic Stem Cell Expansion by Activating Notch Signal Pathway

The authors report that TNFSF15, a member of the tumor necrosis factor superfamily, promoted the expansion of human umbilical cord blood‐derived hematopoietic stem cells.
[Journal of Cellular and Molecular Medicine]
Ding, Y., Gao, S., Shen, J., Bai, T., Yang, M., Xu, S., Gao, Y., Zhang, Z., & Li, L. (n.d.). TNFSF15 facilitates human umbilical cord blood haematopoietic stem cell expansion by activating Notch signal pathway. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15626 Cite
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Mature Twin Neonates Exhibit Oxidative Stress via Nitric Oxide Synthase Dysfunctionality: A Prognostic Stress Marker in the Red Blood Cells and Umbilical Cord Vessels

The authors studied the nitric oxide synthase activation pathways along with damages to macromolecules in the endothelium of umbilical cord vessels and red blood cells of mature non-discordant twins, in connection to major differences in their birth weight.
[Antioxidants]
Chakraborty, P., Dugmonits, K. N., Orvos, H., & Hermesz, E. (2020). Mature Twin Neonates Exhibit Oxidative Stress via Nitric Oxide Synthase Dysfunctionality: A Prognostic Stress Marker in the Red Blood Cells and Umbilical Cord Vessels. Antioxidants, 9(9), 845. https://doi.org/10.3390/antiox9090845 Cite
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Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity

Researcchers extensively compared the physiological functions of human Wharton’s jelly-derived mesenchymal stem cells in a xeno-free medium and a medium containing 10% fetal bovine serum.
[Journal of Clinical Medicine]
Kang, J. Y., Oh, M.-K., Joo, H., Park, H. S., Chae, D.-H., Kim, J., Lee, H.-R., Oh, I.-H., & Yu, K.-R. (2020). Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity. Journal of Clinical Medicine, 9(9), 2913. https://doi.org/10.3390/jcm9092913 Cite
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Selective Inhibition of Coxiella burnetii Replication by the Steroid Hormone Progesterone

During infection of placental-derived JEG-3 cells, C. burnetii showed sensitivity to progesterone, but not the immediate precursor pregnenolone, or estrogen, another major mammalian steroid hormone.
[Infection and Immunity]
Howard, Z. P., & Omsland, A. (2020). Selective inhibition of Coxiella burnetii replication by the steroid hormone progesterone. Infection and Immunity. https://doi.org/10.1128/IAI.00894-19 Cite
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Umbilical Cord Mesenchymal Stem Cells Protect Thymus Structure and Function in Aged C57 Mice by Downregulating Aging-Related Genes and Upregulating Autophagy- and Anti-Oxidative Stress-Related Genes

Scientists studied the effect of allogeneic umbilical cord mesenchymal stem cell transplantation on the structure and function of the thymus in aged C57 mice and provided a new method for the treatment of senile thymic atrophy.
[Aging]
Aging | Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes - Full Text. (n.d.). Retrieved September 16, 2020, from https://www.aging-us.com/article/103594/text Cite
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In Vitro Function and In Situ Localization of Multidrug Resistance-Associated Protein (MRP)1 (ABCC1) Suggest a Protective Role against Methyl Mercury-Induced Oxidative Stress in the Human Placenta

The authors concluded that MRP1 protected placental cells from methyl mercury-induced oxidative stress by exporting the toxic metal and by maintaining the placental cells’ glutathione status in equilibrium.
[Archives of Toxicology]
Granitzer, S., Ellinger, I., Khan, R., Gelles, K., Widhalm, R., Hengstschläger, M., Zeisler, H., Desoye, G., Tupova, L., Ceckova, M., Salzer, H., & Gundacker, C. (2020). In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta. Archives of Toxicology. https://doi.org/10.1007/s00204-020-02900-5 Cite
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Advantage of Fat-Derived CD73 Positive Cells from Multiple Human Tissues, Prospective Isolated Mesenchymal Stromal Cells

CD73-positive population from various tissues existed individually in flowcytometric pattern, especially subcutaneous fat- and amniotic-derived cells showed the highest enrichment of CD73-positive cells.
[Scientific Reports]
Suto, E. G., Mabuchi, Y., Toyota, S., Taguchi, M., Naraoka, Y., Itakura, N., Matsuoka, Y., Fujii, Y., Miyasaka, N., & Akazawa, C. (2020). Advantage of fat-derived CD73 positive cells from multiple human tissues, prospective isolated mesenchymal stromal cells. Scientific Reports, 10(1), 15073. https://doi.org/10.1038/s41598-020-72012-8 Cite
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Exploring the NK Cell Platform for Cancer Immunotherapy

The authors highlight the variety of ways in which diverse NK cell products and their auxiliary therapeutics are being leveraged to target human cancers. They also identify future avenues for NK cell therapy research.
[Nature Reviews Clinical Oncology]
Myers, J. A., & Miller, J. S. (2020). Exploring the NK cell platform for cancer immunotherapy. Nature Reviews Clinical Oncology, 1–16. https://doi.org/10.1038/s41571-020-0426-7 Cite
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Activation of Wnt Signaling by Amniotic Fluid Stem Cell-Derived Extracellular Vesicles Attenuates Intestinal Injury in Experimental Necrotizing Enterocolitis

Scientists demonstrated that amniotic fluid stem cells and extracellular vesicles attenuated necrotizing enterocolitis intestinal injury by activating the Wnt signaling pathway.
[Cell Death & Disease]
Li, B., Lee, C., O’Connell, J. S., Antounians, L., Ganji, N., Alganabi, M., Cadete, M., Nascimben, F., Koike, Y., Hock, A., Botts, S. R., Wu, R. Y., Miyake, H., Minich, A., Maalouf, M. F., Zani-Ruttenstock, E., Chen, Y., Johnson-Henry, K. C., De Coppi, P., … Pierro, A. (2020). Activation of Wnt signaling by amniotic fluid stem cell-derived extracellular vesicles attenuates intestinal injury in experimental necrotizing enterocolitis. Cell Death & Disease, 11(9), 1–12. https://doi.org/10.1038/s41419-020-02964-2 Cite
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