A novel and viable cell-free therapeutic strategy by umbilical cord-MSC-derived exosomes was proposed.
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Xin, L., Lin, X., Zhou, F., Li, C., Wang, X., Yu, H., … Zhang, S. (2020). A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2020.06.029 Cite
Researchers analyzed the lipid profile of fetal serum from untreated intrahepatic cholestasis of pregnancy (ICP), ursodeoxycholic acid (UDCA)-treated ICP and uncomplicated pregnancies and found that UDCA ameliorated ICP-associated fetal dyslipidemia.
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Borges Manna, L., Papacleovoulou, G., Flaviani, F., Pataia, V., Qadri, A., Abu-Hayyeh, S., … Williamson, C. (2020). Ursodeoxycholic acid improves feto-placental and offspring metabolic outcomes in hypercholanemic pregnancy. Scientific Reports, 10(1), 10361. https://doi.org/10.1038/s41598-020-67301-1 Cite
Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
Hutchison China MediTech Limited announced that the FDA has granted Fast Track Designation for the development of fruquintinib, for the treatment of patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and, if RAS wild-type, an anti-epidermal growth factor receptor therapy.
[Hutchison China MediTech Limited ]
Bio-Thera Solutions announced that the China National Medical Products Administration (NMPA) has accepted the Biologics License Application for BAT1706, a proposed biosimilar to Avastin®.
[Bio-Thera Solutions (Business Wire, Inc.)]
The authors summarize the current preclinical and clinical studies performed to investigate the regenerative potential of Wharton’s jelly‐derived mesenchymal stem cells in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
[Journal of Cellular Physiology]
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Abbaszadeh, H., Ghorbani, F., Derakhshani, M., Movassaghpour, A. A., Yousefi, M., Talebi, M., & Shamsasenjan, K. (n.d.). Regenerative potential of Wharton’s jelly-derived mesenchymal stem cells: A new horizon of stem cell therapy. Journal of Cellular Physiology, n/a(n/a). https://doi.org/10.1002/jcp.29810 Cite
Researchers investigated the anti-fibrotic activity of a flowable placental formulation using a bleomycin-induced dermal fibrosis model in aged mice.
[European Journal of Human Genetics]
The authors summarize the current preclinical and clinical studies performed to investigate the regenerative potential of WJ‐MSCs in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
[Journal of Cellular Physiology]
Scientists investigated adding haplo-identical CD34+ cells to double unit cord blood (CB) grafts to facilitate early haplo-identical donor-derived neutrophil recovery prior to CB engraftment.