Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
Subscribe|Follow Us On
Piezo1 Activation in Endothelial Cells Aggravates Microvascular Ischemia-Reperfusion Injury in Limbs by Enhancing Ferroptosis
[Experimental & Molecular Medicine] Evaluations of limb vitality, western blot, quantitative PCR, and immunofluorescence implicated that activation of Piezo1 exacerbates ischemia/reperfusion-induced microvascular perfusion deficits, tissue swelling, skeletal muscle damage and increased tissue infarction, and microvascular endothelial cell damage.
Propofol Attenuates Angiogenesis by Activating Endoplasmic Reticulum Stress to Suppress TFAP2C-Driven VEGFA Transcription
[Apoptosis] Scientists examined the effects of propofol on VEGFA-mediated angiogenesis in vitro and in vivo. Propofol triggers endoplasmic reticulum stress by promoting phosphorylation of protein kinase R-like endoplasmic reticulum kinase and its downstream effector eIF2α.
King’s Awarded £2.1m to Test Treatment for Disease That Causes Leg Pain
[King's College London] Researchers at King's College London have been awarded £2.1m in funding to take a new regenerative, cell-based therapy for leg pain caused by reduced blood flow to clinical trial.
GPS2 Regulates Embryonic Angiogenesis by Enhancing Endothelial Cell Survival through Stabilizing HOIP
[Cell Death & Differentiation] Researchers uncovered a novel role of G protein pathway suppressor 2 (GPS2) in regulating endothelial cell survival and embryonic vascularization via control of HOIP stability.
Spatial Profiling Shows That Lymphatic Endothelial Cells Form the Core of Kaposi Sarcoma (KS)
[Modern Pathology] Investigators performed concurrent spatial imaging of five bona fide lymphatic endothelial cell markers together with the KS herpesvirus viral protein LANA in thirty well-characterized HIV-positive KS biopsies.
Biofabrication of 3D Bioprinted and Organ-on-Chip Blood-Brain Barrier Models Using hCMEC/D3 for Intranasal Delivery of Central Nervous System Therapeutics
[Biofabrication] The authors critically explore how human cerebral microvascular endothelial cell line (hCMEC/D3) models support the development of intranasal drug delivery strategies.
Endoglin as a BMP9 Co-Receptor in Vascular Endothelial Cells: Prodomain Displacement and TGFBRII Recruitmen
[Nature Communications] Endoglin (ENG) efficiently displaces prodomains from BMP9 and BMP10, enabling effective capturing of both ligands from the circulation, and binds to and recruits TGFBRII into the BMP9 signalling complex, thereby explaining ENG’s involvement in both TGF-β and BMP9 pathways.
Inhibition of PAK2 in Endothelial Cells Suppresses Tumor Angiogenesis and Promotes Immune Sensitization through CXCL10
[Cell Reports] Scientists showed that endothelial-specific deletion of p21-activated kinase 2 (PAK2) in orthotopic tumor mouse models markedly reduces tumor size and angiogenesis.
SULF1’s Role in Endothelial Senescence and Atherosclerosis: Insights from Single-Cell and Bulk Transcriptomics
[Journal of Inflammation Research] Investigators highlight the critical role of endothelial senescence in atherosclerosis and identify SULF1 as a key contributor to endothelial senescence and atherogenesis.
Multidimensional Dynamic Optical Imaging Unveils Anesthetic-Driven Hemispheric Lateralization in Blood-Brain Barrier Homeostasis
[Science Advances] Scientists found that isoflurane facilitates hemispheric lateralization in blood-brain barrier permeability, leading to different responses between the left and right hemispheres.
Distinguishing Subtypes of Endothelial Cells in the Mouse Aorta
[Proceedings of The National Academy of Sciences of The United States of America] Contrary to the assumption that all endothelial cells originated from the luminal surface, investigators identified two distinct sites of origin: aortic lumen and peri-aortic microvascular.
Endothelial Cells Sialylate IgG within the FcRn-Mediated Recycling Pathway
[Proceedings of The National Academy of Sciences of The United States of America] The authors found that IgG sialylation occurs in the subcellular compartments of the FcRn-mediated IgG recycling pathway of endothelial cells.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
