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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
Sphingosine-1-Phosphate (S1P) in Whole Liver Recellularization Improves Endothelization of Acellular Liver Scaffold
[ACS Biomaterials Science & Engineering] Researchers presented a novel approach to enhance the re-endothelialization of decellularized rat liver scaffolds by seeding HUVECs in the presence of S1P, aiming to bioengineer a fully endothelialized liver.
3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene Signatures
[Advanced Science] A multicellular approach was employed using human glia and vascular cells to optimize a 3D brain vascular niche model that enables not only long-term culture of patient derived glioblastoma (GBM) cells but also recapitulation of key features of GBM heterogeneity.
S1PR1 Regulates Lymphatic Valve Development and Tertiary Lymphoid Organ Formation in the Ileum
[Journal of Experimental Medicine] The authors showed that the deletion of the GPCR sphingosine 1-phosphate receptor-1 (S1PR1) from lymphatic endothelial cells results in fewer lymphatic valves.
Bone Morphogenetic Protein-9 Controls Pulmonary Vascular Growth and Remodeling
[Proceedings of The National Academy of Sciences of The United States of America] Researchers revealed that BMP-9 signaling intersects with VEGF pathways and contributes to the delicate balance between vascular growth and remodeling in the lungs.
Truncated NTRK2 Is Induced in CAP1 Endothelial Cells during Mouse Lung Injury-Repair
[iScience] Using single-cell multiome and mouse genetics, the authors characterized the induction and function of a truncated isoform of Ntrk2, Ntrk2-T1, in multiple lung injury models.
Engineering Osteogenic Spheroids: The Impact of Endothelial Cell Localization on Vascularization and Differentiation.
[Advanced Healthcare Materials] Researchers investigated the influence of endothelial cell positioning within co-cultured spheroids on vascularization and osteogenic differentiation.
Vascular Access Student Club Wins National Awards
[McGill University] The Ingram School of Nursing’s Vascular Access Student Club team of talented executives and dedicated faculty advisors scored big at the 2025 National Canadian Vascular Access Association Conference.
£2.5 Million for Largest Trial to Improve Outcomes from Treatment for Blocked Leg Arteries
[University of Bristol] Funded by £2.5 million from the National Institute for Health and Care Research, (NIHR), CLARITY PAD will evaluate three different combinations of blood-thinning tablets — clopidogrel; aspirin and clopidogrel, and aspirin and rivaroxaban.
Endothelial Progenitor Cells: Disease Markers and Potential Therapy in Kidney Disease
[Journal of The American Society of Nephrology] Scientists review the current state and recent advances in understanding of the role of endothelial progenitor cell in homeostasis and conditions that may lead to their dysregulation in kidney diseases.
Intestinal Lymphatic Vasculature Is Functionally Adapted to Different Drainage Regions and Is Altered by Helminth Infection
[Journal of Experimental Medicine] Parallel RNA sequencing of lymphatic endothelial cells and mucosa along the intestine revealed that the transcriptomes overlapped in functional profiles.
Endothelial Cells-Derived SEMA3G Suppresses Glioblastoma Stem Cells by Inducing c-Myc Degradation
[Cell Death & Differentiation] The authors revealed that endothelial cell-derived SEMA3G, which is aberrantly expressed in glioblastoma patients, impairs glioblastoma stem cells by inducing c-Myc degradation.
Strategies for the Vascular Patterning of Engineered Tissues for Organ Repair
[Nature Biomedical Engineering] For tissue regeneration to be clinically viable, vascular formation must be guided across scales ranging from micrometres to millimetres through biological, chemical and physical approaches.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
