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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
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Nuclear eNOS Interacts with and -Nitrosates ADAR1 to Modulate Type I Interferon Signaling and Endothelial Function
[Circulation] Researchers assessed the relevance of nuclear endothelial nitric oxide (NO) synthase and NO signaling for endothelial cell function.
Tannin-Mediated Ischemia-Homing-Angiogenesis Nanodots (IHAND) for Synergistic Angiogenesis and Heart Failure Prevention Post-Myocardial Infarction
[Advanced Materials] Scientists presented the first IHAND that simultaneously modulates vascular endothelial cells and macrophages to achieve efficient angiogenesis in myocardial infarction tissues.
The Brain Neurovascular Epigenome and Its Association with Dementia
[Neuron] Investigators generated gene regulomes for human brain endothelial cells (BECs), mural cells, and other brain cell types and showed that Alzheimer's disease heritability is primarily immune-related, with a modest BEC enrichment.
Molecular Profiling of Brain Endothelial Cell to Astrocyte Endfoot Communication in Mouse and Human
[Nature Communications] Researchers developed a method to define the mouse in vivo astrocyte endfoot proteome, which in combination with brain endothelial cell (BEC)-specific RNA-seq, revealed BEC to astrocyte endfoot ligand-receptor pairs that are modulated when mice are exposed to a peripheral inflammatory insult with lipopolysaccharide.
Descendants of Hypertrophic Chondrocytes Promote Angiogenesis by Secreting THBS4 during Bone Growth and Injury Repair
[Bone Research] The authors demonstrated a critical role of pro-angiogenic descendants in bone growth and injury repair by secreting thrombospondin 4 to regulate angiogenesis.
Characterization of Sex-Based Differences in Integrin-Mediated Endothelial Cell Adhesion to Bioactive Hydrogels
[ACS Biomaterials Science & Engineering] Investigators elucidated sex differences in endothelial cell-material interactions through an investigation of the integrin-ligand interplay with biomaterial substrates and the corollary effects on cell adhesion and spreading.
Ferroptosis of Macrophages and Endothelial Cells in Atherosclerosis: Molecular Mechanisms and Therapeutic Targets
[Reviews In Cardiovascular Medicine] The authors update the knowledge of ferroptosis in endothelial cells and macrophages related to atherosclerosis (AS), identify potential links and the subsequent implications for plaque stability, and serve as a reference for developing new pharmacological strategies to address AS and stabilize vulnerable plaques.
4DMT Announces Positive Long-Term Data from Phase 1/2 PRISM Clinical Trial in Wet AMD Supporting 4D-150’s Potential as a Backbone Therapy with Consistent and...
[4D Molecular Therapeutics] 4D Molecular Therapeutics announced positive interim 1.5- to 3.5-year data from the Phase I/II PRISM clinical trial evaluating 4D-150 in patients with wet age-related macular degeneration.
Valitor Presents Preclinical Data Demonstrating VLTR-559 Achieves Superior Durability and Sustained Anti-VEGF Activity with a Favorable Safety Profile as a Treatment for Wet AMD
[Valitor] Valito announced new preclinical data demonstrating that VLTR-559, a long-acting anti-VEGF biologic designed to enable twice-yearly dosing for the treatment of wet age-related macular degeneration (AMD), achieved its preclinical durability and safety targets compared with approved short-acting anti-VEGF therapies for wet AMD.
Site-1 Protease-Mediated Cholesterol Metabolism Is Essential for Lymphatic Development in Mice
[JCI Insight] Investigators generated mice with pan-endothelial or lymphatic endothelial cells-specific deficiency of either site-1 protease (S1P) or sterol regulatory element-binding proteins 2. Mouse embryos with pan-endothelial deletion of S1P showed defective lymphatic vessel migration in skin and lymphedema, while their blood vasculature formation was relatively normal.
Long-Pulsed 1064-Nm Neodymium: Yttrium-Aluminum-Garnet Laser Alleviates Rosacea by Improving Lymphatic Vessel Dysfunction
[Inflammation Research] Researchers investigated potential lymphatic vessel abnormalities associated with rosacea and elucidate effective rosacea treatment mechanism using long-pulsed 1064-nm neodymium: yttrium-aluminum-garnet laser.
DEAD-Box Helicase DDX24 Is Essential for Endothelial Mitochondrial Function to Maintain the Blood-Brain Barrier
[Cell Reports] Researchers uncovered a pivotal role for DDX24 in regulating the blood-brain barrier (BBB) via mediating mitochondrial function in endothelial cells, providing a potential therapeutic target for treating BBB-related diseases.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
