Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

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Endothelial Cell Responses in Sepsis Are Attenuated by Targeting Truncated Procalcitonin

January 26, 2026

[Nature Communications] Scientists evaluated the efficacy of targeting procalcitonin for vascular integrity and sepsis outcomes. Sepsis up-regulates >2000 genes involved in pro-inflammatory responses while similar numbers of genes involving cell growth and maintenance are down-regulated.

Endothelial Stem Cells of the Retinal Vasculature Reside in the Optic Nerve

January 26, 2026

[Nature Communications] Through single-cell RNA sequencing, colony-forming assays, and lineage tracing analysis, researchers provided data that point to a new regulatory system by which vascular endothelial cells are supplied to the retina by a reservoir of stem/progenitor cells in the optic nerve.

Engineered Small Extracellular Vesicles Targeting Tumor-Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment

January 26, 2026

[Advanced Science] Investigators modified small extracellular vesicles with insulin-like growth factor-binding protein 7 to create a delivery platform that can deliver therapeutic agents to glioma-associated vascular endothelial cells with high efficiency.

Dynamic Regulation of Receptor-Modulated Endothelial NADPH Oxidases

January 26, 2026

[Proceedings of The National Academy of Sciences of The United States of America] Researchers defined the redox states of various subcellular locales in the vascular endothelium and demonstrate that NOX2 is responsible for cytosolic H₂O₂ signaling, whereas NOX4 contributes to H₂O₂ generation in the endoplasmic reticulum.

Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions

January 26, 2026

[Advanced Healthcare Materials] Scientists engineered 3D lymphatic microvessels by co-culturing human lymphatic endothelial cells with human bone marrow-derived mesenchymal stromal cells in synthetic and fully defined enzymatically crosslinked poly(ethylene glycol) hydrogels.

Induction of Neurodegeneration in the Hippocampus of Senescence-Accelerated Mouse-Prone 8 (SAMP8) Mice by Blood-Brain Barrier-Crossing Serum Amyloid P Component

January 26, 2026

[Journal of Neuroinflammation] Investigators analyzed how age-related changes in blood components induce blood-brain barrier structure disruption and neurodegeneration using 6-month-old SAMP8 mice.

ATF4 Regulates Mitochondrial Dysfunction and Mitophagy, Contributing to Corneal Endothelial Apoptosis

January 26, 2026

[Scientific Reports] The authors investigated the role of ATF4 in regulating mitochondrial dysfunction and mitophagy, which ultimately leads to corneal endothelial cell apoptosis.

ALDH2 and NFκB Activation Restores VEGFR2 Expression and Angiogenesis Impaired by 4-HNE in Coronary Endothelial Cells

January 26, 2026

[Cell Biochemistry and Function] Researchers hypothesized that activation of aldehyde dehydrogenase 2 (ALDH2) enhances nuclear factor kappa B (NFκB) signaling, thereby preventing the 4-hydroxy-2-nonenal (4HNE)-induced reduction in vascular endothelial growth factor receptor 2 (VEGFR2) expression and restoring angiogenesis.

Development of the Blood-Brain Barrier

January 26, 2026

[Development] Scientists summarize current understanding of blood–brain barrier development, including timing and underlying cellular and molecular mechanisms.

Winner of 2026 ARVO Foundation Research Catalyst Award Announced

January 26, 2026

[The Association for Research in Vision and Ophthalmology (ARVO)] Dr. Rose Tan has been named the 2026 recipient of the ARVO Foundation Research Catalyst Award. Tan's current research focuses on characterizing chorioretinal microvasculature and neurodegenerative changes in diabetic retinopathy.

Piezo1 Activation in Endothelial Cells Aggravates Microvascular Ischemia-Reperfusion Injury in Limbs by Enhancing Ferroptosis

January 12, 2026

[Experimental & Molecular Medicine] Evaluations of limb vitality, western blot, quantitative PCR, and immunofluorescence implicated that activation of Piezo1 exacerbates ischemia/reperfusion-induced microvascular perfusion deficits, tissue swelling, skeletal muscle damage and increased tissue infarction, and microvascular endothelial cell damage.

Propofol Attenuates Angiogenesis by Activating Endoplasmic Reticulum Stress to Suppress TFAP2C-Driven VEGFA Transcription

January 12, 2026

[Apoptosis] Scientists examined the effects of propofol on VEGFA-mediated angiogenesis in vitro and in vivo. Propofol triggers endoplasmic reticulum stress by promoting phosphorylation of protein kinase R-like endoplasmic reticulum kinase and its downstream effector eIF2α.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.