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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
University of Missouri Conducts First In-Person Clinical Trial for Nuclear Medicine Breakthrough Device
[University of Missouri] In a major leap for cancer care at the University of Missouri, the School of Medicine and MU Health Care have launched their first clinical trial using a leading-edge therapy manufactured on campus at the universityās research reactor.
Activated ATF6Ī± Is a Hepatic Tumor Driver Restricting Immunosurveillance
[Nature] Scientists demonstrated the function of ATF6Ī± as an endoplasmic reticulum (ER)-stress-inducing tumor driver and metabolic master regulator restricting cancer immunosurveillance for hepatocellular carcinoma, in contrast to its well-characterized role as an adaptive response to ER stress.
Diploid Hepatocytes Resist Acetaminophen-Induced Liver Injury through Suppressed JNK Signaling
[Cell Death & Disease] Researchers investigated how hepatocyte ploidy affects susceptibility to acetaminophen-induced liver injury by comparing diploid-enriched liver-specific knockout of E2f7/E2f8 and polyploid-enriched control mice.
EP300 Promotes Hepatocellular Carcinoma Proliferation, Migration, and In Vivo Tumorigenicity Revealed by Integrated Experimental, and Bioinformatic Analyses
[Journal of Translational Medicine] Investigators found that EP300 is consistently upregulated in hepatocellular carcinoma and supports malignant phenotypes in vitro and in vivo.
Targeted Degradation of Lin28B Using Pre-Let-7-PROTACs for Hepatocellular Carcinoma Therapy
[Journal of Medicinal Chemistry] The authors confirmed that pre-let-7-PROTACs reduce tumor stemness by degrading Lin28B, offering a promising therapeutic approach for hepatocellular carcinoma.
TGFBI Promotes Liver Fibrosis through Remodeling the Profibrotic Microenvironment by a Positive Feedback Regulatory Loop
[Communications Biology] Researchers showed that transforming growth factor-beta-induced protein (TGFBI) promotes liver fibrosis in male C57BL/6 mice. TGFBI was upregulated in fibrotic livers and derived from non-parenchymal cells.
Liver Fibrosis and Type 2 Diabetes Modulate Postprandial Incretin and Glucagon Responses in Fatty Liver Disease
[Journal of Physiology and Biochemistry] Scientists uncovered how fibrosis and diabetes interact to modulate enterohepatic communication, providing insights into metabolic-associated steatotic liver disease pathophysiology and identifying potential therapeutic targets for disease management.
Applications and Limitations of Pluripotent Stem Cell-Derived Liver Organoids
[Chinese Medical Journal] Scientists provide an overview of liver organoid development and discusses their applications in liver regeneration, disease modeling, drug screening, toxicity assessment, organ transplantation, and regenerative medicine.
National Academy of Inventors Honors VCUās Shunlin Ren As a Fellow
[Virginia Commonwealth University] Shunlin Ren, M.D., Ph.D., was notified of the election to the 2025 class of fellows of the National Academy of Inventors, the highest professional distinction for academic inventors in the United States.
Novel Tetrahydroxanthylium-Based Ligands Targeting Mitochondrial DNA G-Quadruplex Structures for Concurrent Induction of Apoptosis and Inhibition of Autophagy in Liver Cancer
[Journal of Medicinal Chemistry] The authors introduced XAN-5, a novel mitochondrial DNA G-quadruplex-targeting tetrahydroxanthylium ligand that can simultaneously induce apoptosis and inhibit autophagy.
Silk Fibroin Scaffolds Loaded with Growth Factors Can Reverse Liver Fibrosis
[Biomaterials Science] Scientists explored the therapeutic potential of regenerated silk fibroin scaffolds loaded with dual growth factors for reversing hepatic fibrosis.
Chlorogenic Acid Alleviates Chronic Restraint Stress-Induced Liver Injury Potentially Nrf2-Mediated Inhibition of Ferroptosis and Mitochondrial Apoptosis
[Food & Function] Scientists demonstrated that chlorogenic acid, a natural antioxidant, markedly alleviates chronic restraint stress-induced liver injury in rats.
The publications featured inĀ Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
