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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
Oncogenic Cholesterol Rewires Lipid Metabolism in Hepatocellular Carcinoma via the CSNK2A1-IGF2R Ser2484 Axis
[Journal of Advanced Research] Scientists investigated the molecular features of alcohol and hepatitis B virus on HCC and sought out potential therapeutic strategies.
Portal Hypertension Contributes to Ascites Formation via the Piezo1-Nuclear Factor Kappa-B-Aquaporin1 Pathway in Liver Cirrhosis
[Experimental & Molecular Medicine] The role of portal hypertension in cirrhotic ascites was determined through a meta-analysis of portal pressure in cirrhotic patients and animal models.
Integrated Single-Cell RNA-Seq Analysis Reveals That EZH2 Regulates the MIF-CD74 Axis to Modulate T Cell Activation and Exhaustion in Hepatocellular Carcinoma
[Journal of Translational Medicine] A 16-gene integrated model was constructed as a prognostic and predictive tool for HCC immunotherapy.
Development of a Decellularized Liver Matrix-Based Nanomedicine for Metabolic Dysfunction-Associated Steatotic Liver Disease
[Biomaterials Science] Scientists developed a novel nanomedicine comprising tannic acid and a decellularized liver matrix—TD-Nm—to promote recovery from metabolic dysfunction-associated steatotic liver disease.
MINPP1 Promotes Ferroptosis in HBV-Related Hepatocellular Carcinoma by Regulating CTSB K33-Linked Deubiquitination via ZRANB1
[Biology Direct] Investigators utilized immunoprecipitation, immunofluorescence, and analysis of ubiquitin modifications to explore the regulatory mechanisms of MINPP1 in ferroptosis and its effects on tumor progression.
In Vivo and In Vitro Metabolism of the Designer Benzodiazepine, Bretazenil: A Comparison of Pooled Human Hepatocytes, and Liver Microsomes with Postmortem Urine, and...
[Archives of Toxicology] The authors aimed to thoroughly explore bretazenil’s metabolism using web-based in silico prediction tools, in vitro incubation with pooled human liver microsomes and hepatocytes, and to compare these results with authentic postmortem blood and urine samples.
Casein Kinase 1 Family Member CSNK1E Can Regulate Proliferation and Migration in Hepatocellular Carcinoma
[Journal of Cancer Research and Clinical Oncology] Researchers elucidated the characterization, prognostic significance, and targeting value of circadian rhythm gene CSNK1E in HCC.
Regulation of Hepatic Stellate Cell Phenotypes in Metabolic Dysfunction-Associated Steatohepatitis
[Gastroenterology] Understanding the mechanisms of HSC activation and their role in MASH progression is essential for developing targeted therapies to treat and prevent liver fibrosis in affected individuals.
Mechanistic Insights Into Post-Translational Modifications in Hepatic Fibrosis: Pathogenic Roles and Therapeutic Potentials
[Journal of Translational Medicine] Researchers explored nine post-translational modifications—methylation, acetylation, SUMOylation, Neddylation, phosphorylation, crotonylation, glycosylation, lactylation, and ubiquitination—each implicated in the pathogenesis of hepatic fibrosis.
Gilead Foundation Grants $6.5 Million in Commitment to STEM Education
[Gilead Sciences, Inc.] Gilead Sciences, Inc. announced that it has committed more than $6.5 million in grant funding toward strengthening science, technology, engineering, and math (STEM) education pathways in the San Francisco Bay Area and beyond.
MASH: The Nexus of Metabolism, Inflammation, and Fibrosis
[Journal of Clinical Investigation] The authors outline how coordinated disruptions in lipid metabolism and intercellular signaling drive metabolic dysfunction–associated steatohepatitis (MASH) pathogenesis and provides a framework for understanding disease progression across tissue and cellular compartments.
KYLO-0603, a Novel Liver-Targeting, Thyroid Hormone receptor-β Agonist for the Inhibition of MASH Progression
[PLOS One] Investigators developed Kylo-0603, a novel agonist for the thyroid hormone receptor β, by merging the structures of three acetylgalactosamine-modified ASPGR ligands with a triiodothyronine analog.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
