Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

Sex-Specific KDM6A-HNF4A-CREBH Network Controls Lipoprotein Cholesterol Metabolism and Atherosclerosis via Epigenetic Reprograming of Hepatocytes

March 26, 2026

[Nature Communications] Researchers showed that the X-linked histone demethylase 6 A (KDM6A) is essential for maintaining healthy cholesterol metabolism in the liver.

Targeted Inhibition of Nrf2 Potentiates Antitumor Immunity and Enhances the Efficacy of Immunotherapy in Hepatocellular Carcinoma

March 26, 2026

[Journal for Immunotherapy of Cancer] Investigators offered a novel strategy to enhance HCC immunotherapy by blocking nuclear factor erythroid 2-related factor 2 (Nrf2), which has the potential to address the low response rates observed with current HCC immunotherapies.

Targeting STE20-Type Kinase MST3 Improves Metabolic Dysfunction-Associated Steatohepatitis Without Affecting Hepatocellular Carcinoma Development in Mice

March 26, 2026

[BMC Medicine] Scientists investigated whether pharmacologic inhibition of MST3 could attenuate the initiation and progression of metabolic dysfunction-associated steatohepatitis-associated HCC in vivo.

Hepatocyte TIA1 Constrains Metabolic Steatohepatitis by Translationally Suppressing Srebf1 mRNA in Stress Granules

March 26, 2026

[Cell Death & Disease] The authors identify T cell intracellular antigen 1 (TIA1) as a crucial hepatoprotective factor that attenuates metabolic dysfunction-associated steatotic liver disease progression by orchestrating stress granule-dependent translational control of Srebf1 mRNA.

Risk Prediction of Hepatocellular Carcinoma after Hepatitis B Surface Antigen Seroclearance in Patients with Chronic Hepatitis B

March 26, 2026

[Alimentary Pharmacology & Therapeutics] Researchers identified independent risk factors of HCC after hepatitis B surface antigen seroclearance and developed and validated a risk prediction model.

The Effect and Mechanism of Albiflorin in Alleviating Hepatic Fibrosis by Mediating Hepatocyte Ferroptosis via the SLC7A11/GPX4 Signaling Pathway

March 26, 2026

[Journal of Ethnopharmacology] Scientists validated the molecular mechanism of albiflorin ALB against liver fibrosis, integrating both in vivo and in vitro experiments with molecular docking and molecular dynamics simulations.

Paecilomyces Hepiali Chen (Cs-4) Polysaccharides Ameliorate Chronic Liver Fibrosis via Inhibiting TGF-β1/Smad and NLRP3/Caspase-1-Mediated Hepatic Stellate Cells Activation In Vivo and In Vitro

March 26, 2026

[Journal of Ethnopharmacology] Investigators provided compelling evidence supporting the potential application of CSP-W for managing chronic liver fibrosis.

Diagnosing Idiosyncratic Drug-Induced Liver Injury: Lessons from Monocyte-Derived Hepatocyte-Like Cells

March 26, 2026

[Expert Opinion on Drug Metabolism & Toxicology] Hepatocyte-like cells generated from monocytes of iDILI patients are being developed as an ex vivo assay to enhance understanding of underlying molecular mechanisms and to assist in drug causality assessment, especially in cases involving multiple agents.

Gyre Therapeutics Announces China’s NMPA Grants Priority Review to the NDA for Hydronidone (F351) for CHB-Induced Liver Fibrosis Treatment

March 26, 2026

[Gyre Therapeutics, Inc.] Gyre Therapeutics, Inc. announced that the Center for Drug Evaluation of China’s National Medical Products Administration has granted priority review status to the New Drug Application for Hydronidone as a treatment for chronic hepatitis B-induced liver fibrosis, which is liver damage resulting from the infection of the hepatitis B virus.

Clusterin Drives Fiber Endocytosis by Mesothelial Cells to Resolve Liver Fibrosis

March 12, 2026

[Gastroenterology] Induction of clusterin and its receptor, low-density lipoprotein receptor-related protein 2, in fibrotic liver was determined using single-cell RNA sequencing and immunofluorescence.

GPR146 in Adipose Tissue Drives Adipose-Liver Crosstalk and Promotes Hepatic Steatosis in Mice

March 12, 2026

[Nature Communications] Researchers identified the orphan G protein-coupled receptor GPR146 as a regulator of hepatic steatosis through adipose–liver crosstalk.

Hepatocyte CEBPA-ORM1 Axis Restricts Alcohol-Associated Liver Disease

March 12, 2026

[Hepatology] Hepatocyte CCAAT/enhancer-binding protein α (CEBPA) was examined for its modulation of alcohol-associated hepatic steatosis and alcohol-associated liver disease.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!