Targeting Epigenetically Maladapted Vascular Niche Alleviates Liver Fibrosis in Nonalcoholic Steatohepatitis

Investigators used multiomics analysis of human cirrhotic liver, a Western diet – and carbon tetrachloride – induced minipig nonalcoholic steatohepatitis model, and genetically modified mice to unravel the landscape of the vascular adaptome at the single-cell level, in which endothelial cells and TH17 cells jointly contributed to liver cirrhosis.
[Science Translational Medicine]
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Functional Characterization of a Bioengineered Liver after Heterotopic Implantation in Pigs

Researchers reported a method for seeding and engrafting primary porcine hepatocytes into a bioengineered liver scaffold previously reendothelialized with human umbilical vein endothelial cells.
[Communications Biology]
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Effect and Mechanism of Vitamin D Activation Disorder on Liver Fibrosis in Biliary Atresia

Researchers investigated the effect of differential expression of CYP2R1 in hepatocytes on the expression of genes related to liver fibrosis in primary hepatic stellate cells of biliary atresia and animal models of cholestasis.
[Scientific Reports]
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Dual-Ligated Metal Organic Framework as Novel Multifunctional Nanovehicle for Targeted Drug Delivery for Hepatic Cancer Treatment

Investigators reported rational design and construction of doxorubicin-loaded nanoscale Zr-based NMOF decorated with active tumor targeting moieties; folic acid, lactobionic acid (LA), glycyrrhetinic acid (GA), and dual ligands of LA and GA, as efficient multifunctional drug delivery system for hepatocellular carcinoma therapy.
[Scientific Reports]
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Ssu72-HNF4α Signaling Axis Classify the Transition from Steatohepatitis to Hepatocellular Carcinoma

Scientists found that liver-specific deletion of Ssu72 phosphatase in mice, leads to a high incidence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, but not hepatocellular carcinoma.
[Cell Death & Differentiation]
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Stem Cell Therapy in Liver Regeneration: Focus on Mesenchymal Stem Cells and Induced Pluripotent Stem Cells

Owing to the recent developments in mesenchymal stem cells and induced pluripotent stem cells, combined with emerging technologies including graphene, nano-biomaterials, and gene editing, precision medicine and individualized clinical treatment may be realized in the near future.
[Pharmacology & Therapeutics]
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Concentration of Na+-Taurocholate-Cotransporting Polypeptide Expressed after In Vitro-Transcribed mRNA Transfection Determines Susceptibility of Hepatoma Cells for Hepatitis B Virus

Investigators utilized in vitro transcribed mRNA to introduce Na+-taurocholate-cotransporting polypeptide (NTCP) into cells. After transfection of mRNA, surface expression and functionality of NTCP was demonstrated by staining with an N-terminal HBV-preS peptide and bile acid uptake.
[Scientific Reports]
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Therapeutic Effectiveness and Safety of Sintilimab-Dominated Triple Therapy in Unresectable Hepatocellular Carcinoma

Scientists evaluated the effectiveness and safety of sintilimab, a programmed cell death protein-1 blockade, combined with sorafenib and transhepatic arterial chemotherapy and embolization in patients with unresectable hepatocellular carcinoma, compared with sintilimab monotherapy and sintilimab-sorafenib duotherapy.
[Scientific Reports]
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Pseudogene-Mediated DNA Demethylation Leads to Oncogene Activation

The authors described a previously unrecognized role for pseudogenes as potent epigenetic regulators that could demethylate and activate oncogenes. They focused on SALL4, a known oncogene in hepatocellular carcinoma with eight pseudogenes.
[Science Advances]
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Ferroptosis in Liver Disease: New Insights into Disease Mechanisms

The authors review recent progress of ferroptosis studies delineating molecular mechanisms underlying the pathophysiology of several common liver diseases including ischemia/reperfusion-related injury, nonalcoholic fatty liver disease, alcoholic liver disease, hemochromatosis, drug-induced liver injury, and hepatocellular carcinoma.
[Cell Death Discovery]
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Metformin Sensitises Hepatocarcinoma Cells to Methotrexate by Targeting Dihydrofolate Reductase

Scientists reported that metformin treatment increased the sensitivity of hepatocarcinoma cells to methotrexate by suppressing the expression of the one-carbon metabolism enzyme dihydrofolate reductase.
[Cell Death & Disease]
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