ERα Inhibits Mesenchymal and Amoeboidal Movement of Liver Cancer Cell via Gα12

Scientists reported the ability of estrogen receptor alpha (ERα) to transcriptionally inhibit G protein subunit alpha 12 (Gα12) responsible for hepatocellular carcinoma worsening.
[International Journal of Cancer]
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VLCAD Inhibits the Proliferation and Invasion of Hepatocellular Cancer Cells through Regulating PI3K/AKT Axis

Researchers aimed to investigate the role and underlying molecule mechanism of very-long-chain acyl-CoA dehydrogenase (VLCAD) in the pathological process of hepatocellular carcinoma.
[Clinical and Translational Oncology]
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MAPK p38/Ulk1 Pathway Inhibits Autophagy and Induces IL-1β Expression in Hepatic Stellate Cells

Investigators revealed a continuous signaling pathway, MAPK p38-Ulk1 phosphorylation-Ulk1/Atg13 disruption, which inhibited autophagy and induced IL-1β expression in hepatic stellate cells.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
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Traf3 Inactivation Promotes the Development of Intrahepatic Cholangiocarcinoma via NIK-Mediated Hepatocyte Transdifferentiation

The authors performed a Sleeping Beauty transposon-based in vivo insertional mutagenesis screen in liver-specific Pten-deficient mice and identified tumor necrosis factor receptor-related factor 3 (Traf3) as the most significantly mutated gene in murine intrahepatic cholangiocarcinoma in a loss-of-function manner.
[Hepatology]
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Lipogenesis Inhibitors: Therapeutic Opportunities and Challenges

Despite challenges related to efficacy, selectivity and safety, several new classes of synthetic de novo lipogenesis inhibitors have entered clinical-stage development and may become the foundation for a new class of therapeutics.
[Nature Reviews Drug Discovery]
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Aligos Therapeutics Expands Collaboration with Merck to Develop Oligonucleotide Therapies for NASH

Aligos Therapeutics, Inc. announced that it has expanded its ongoing collaboration agreement with Merck to discover and develop oligonucleotide therapies for non-alcoholic steatohepatitis (NASH).
[Aligos Therapeutics, Inc.]
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COUR Pharmaceuticals Receives FDA Fast Track Designation for CNP-104 for the Treatment of Primary Biliary Cholangitis

COUR Pharmaceuticals announced the US FDA granted Fast Track Designation to the company’s investigational therapy CNP-104 for the treatment of primary biliary cholangitis.
[COUR Pharmaceuticals (PR Newswire, Inc.)]
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Neutrophils as Potential Therapeutic Targets in Hepatocellular Carcinoma

The authors outline the evidence in support of neutrophils as drivers of hepatocellular carcinoma and detail their mechanistic roles in development, progression and metastasis, highlighting the reasons that neutrophils are well worth investigating despite the challenges associated with studying them.
[Nature Reviews Gastroenterology & Hepatology]
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Exosomal hsa_circ_0004658 Derived from RBPJ Overexpressed-Macrophages Inhibits Hepatocellular Carcinoma Progression via miR-499b-5p/JAM3

Scientists assessed the role of exosomes derived from recombination signal binding protein-Jκ (RBPJ)-overexpressed macrophages in hepatocellular carcinoma.
[Cell Death & Disease]
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Plasmolipin Regulates Basolateral-to-Apical Transcytosis of ICAM-1 and Leukocyte Adhesion in Polarized Hepatic Epithelial Cells

Researchers investigated the molecular mechanisms that determined intercellular adhesion receptor (ICAM)-1 localization into apical membrane domains of polarized hepatic epithelial cells, and their effect on lymphocyte-hepatic epithelial cell interaction.
[Cellular and Molecular Life Sciences]
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The Cancer-Testis lncRNA Lnc-CTHCC Promotes Hepatocellular Carcinogenesis by Binding hnRNP K and Activating YAP1 Transcription

The authors discovered a conserved cancer-testis (CT)-long non-coding RNAs (lncRNA), named lnc-CTHCC, which was highly expressed in the testes and hepatocellular carcinoma.
[Nature Cancer]
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