Induced Hepatic Stellate Cell Integrin, α8β1, Enhances Cellular Contractility and TGFβ Activity in Liver Fibrosis

Integrin α‐subunits were investigated systematically for their expression over the course of hepatic stellate cells activation and their distribution on fibroblasts and other systemic primary cells.
[Journal of Pathology]
Nishimichi, N., Tsujino, K., Kanno, K., Sentani, K., Kobayashi, T., Chayama, K., Sheppard, D., & Yokosaki, Y. (n.d.). Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis. The Journal of Pathology, n/a(n/a). https://doi.org/https://doi.org/10.1002/path.5618 Cite
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MicroRNA-494-3p Prevents Liver Fibrosis and Attenuates Hepatic Stellate Cell Activation by Inhibiting Proliferation and Inducing Apoptosis through Targeting TRAF3

Alcoholic hepatitis mice model and primarily cultured mice hepatic stellate cells model were constructed. Levels of aspartate aminotransferase and alanine aminotransferase were analyzed by ELISA.
[Annals of Hepatology]
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Application of Self-Assembly Peptides Targeting the Mitochondria as a Novel Treatment for Sorafenib-Resistant Hepatocellular Carcinoma Cells

Mitochondria-accumulating self-assembly peptides (Mito-FF) were found to significantly promote cell apoptosis while inhibiting cell proliferation of Mito-FF against sorafenib-resistant Huh7 cells.
[Scientific Reports]
Hong, T. H., Jeena, M. T., Kim, O.-H., Kim, K.-H., Choi, H. J., Lee, K. H., Hong, H.-E., Ryu, J.-H., & Kim, S.-J. (2021). Application of self-assembly peptides targeting the mitochondria as a novel treatment for sorafenib-resistant hepatocellular carcinoma cells. Scientific Reports, 11(1), 874. https://doi.org/10.1038/s41598-020-79536-z Cite
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1H-NMR Metabolomics Reveals a Multitarget Action of Crithmum maritimum Ethyl Acetate Extract in Inhibiting Hepatocellular Carcinoma Cell Growth

Researchers showed that Crithmum maritimum ethyl acetate extract counteracted the Warburg effect, by reducing intracellular lactate, inhibited protein anabolism, by decreasing amino acid level, and affected membrane biosynthesis by lowering choline and phosphocholine.
[Scientific Reports]
Gnocchi, D., Del Coco, L., Girelli, C. R., Castellaneta, F., Cesari, G., Sabbà, C., Fanizzi, F. P., & Mazzocca, A. (2021). 1 H-NMR metabolomics reveals a multitarget action of Crithmum maritimum ethyl acetate extract in inhibiting hepatocellular carcinoma cell growth. Scientific Reports, 11(1), 1259. https://doi.org/10.1038/s41598-020-78867-1 Cite
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Gilead and Vir Biotechnology Establish Clinical Collaboration to Explore Combination Strategies for Functional Cure for Chronic Hepatitis B Virus

Gilead Sciences, Inc. and Vir Biotechnology, Inc. announced that the companies have entered into a clinical collaboration to evaluate novel therapeutic combination strategies aimed at developing a functional cure for chronic hepatitis B virus.
[Gilead Sciences, Inc. (BusinessWire, Inc)]
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Chemotherapy-Enriched THBS2-Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications

The local soft spots created by liver cancer stem cells could enhance stemness and drug resistance and provide a route of escape to facilitate hepatocellular carcinoma metastasis.
[Advanced Science]
Ng, K.-Y., Shea, Q. T., Wong, T.-L., Luk, S. T., Tong, M., Lo, C.-M., Man, K., Yun, J.-P., Guan, X.-Y., Lee, T. K., Zheng, Y.-P., & Ma, S. (n.d.). Chemotherapy-Enriched THBS2-Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications. Advanced Science, n/a(n/a), 2002483. https://doi.org/https://doi.org/10.1002/advs.202002483 Cite
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Generation of Proliferating Human Adult Hepatocytes Using Optimized 3D Culture Conditions

The authors describe optimized 3D culture conditions of primary human hepatocytes to trigger two waves of proliferation and identified matrix stiffness and cell–cell interactions as the main actors necessary for this proliferation.
[Scientific Reports]
Rose, S., Ezan, F., Cuvellier, M., Bruyère, A., Legagneux, V., Langouët, S., & Baffet, G. (2021). Generation of proliferating human adult hepatocytes using optimized 3D culture conditions. Scientific Reports, 11(1), 515. https://doi.org/10.1038/s41598-020-80019-4 Cite
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LECT2 as a Hepatokine Links Liver Steatosis to Inflammation via Activating Tissue Macrophages in NASH

Hepatic expression of leukocyte cell-derived chemotaxin 2 (LECT2) was upregulated in association with the inflammatory signature in human liver tissues. The elevation of LECT2 shifted liver residual macrophage to the M1-like phenotype, and contributed to the development of liver inflammation.
[Scientific Reports]
Takata, N., Ishii, K., Takayama, H., Nagashimada, M., Kamoshita, K., Tanaka, T., Kikuchi, A., Takeshita, Y., Matsumoto, Y., Ota, T., Yamamoto, Y., Yamagoe, S., Seki, A., Sakai, Y., Kaneko, S., & Takamura, T. (2021). LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH. Scientific Reports, 11(1), 555. https://doi.org/10.1038/s41598-020-80689-0 Cite
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High-Fat Diet-Induced Upregulation of Exosomal Phosphatidylcholine Contributes to Insulin Resistance

The authors showed that lean mice became insulin resistant after being administered exosomes isolated from the feces of obese mice fed a high-fat diet or from patients with type II diabetes.
[Nature Communications]
Kumar, A., Sundaram, K., Mu, J., Dryden, G. W., Sriwastva, M. K., Lei, C., Zhang, L., Qiu, X., Xu, F., Yan, J., Zhang, X., Park, J. W., Merchant, M. L., Bohler, H. C. L., Wang, B., Zhang, S., Qin, C., Xu, Z., Han, X., … Zhang, H.-G. (2021). High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance. Nature Communications, 12(1), 213. https://doi.org/10.1038/s41467-020-20500-w Cite
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Engineering Human Hepato-Biliary-Pancreatic Organoids from Pluripotent Stem Cells

Investigators describe a protocol for the continuous patterning of hepatic, biliary and pancreatic structures from a 3D culture of human pluripotent stem cells.
[Nature Protocols]
Koike, H., Iwasawa, K., Ouchi, R., Maezawa, M., Kimura, M., Kodaka, A., Nishii, S., Thompson, W. L., & Takebe, T. (2021). Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells. Nature Protocols, 1–18. https://doi.org/10.1038/s41596-020-00441-w Cite
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Histone Deacetylase 2 Regulates ULK1 Mediated Pyroptosis during Acute Liver Failure by the K68 Acetylation Site

Researchers investigated whether knockdown or pharmacological inhibition of histone deacetylase 2 could reduce the level of pyroptosis in acute liver failure (ALF) through ULK1-NLRP3-pyroptosis pathway.
[Cell Death & Disease]
Wang, Y., Chen, Q., Jiao, F., Shi, C., Pei, M., Wang, L., & Gong, Z. (2021). Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site. Cell Death & Disease, 12(1), 1–17. https://doi.org/10.1038/s41419-020-03317-9 Cite
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