Researchers found that aberrant activation of mTORC1 was likely attributed to the reduction of DEP domain-containing protein 5 in the livers of ethanol-fed mice or alcohol-related liver disease patients.
[Cell Death & Disease]
6445212 G8ZPZ24G items 1 apa default asc 1
Researchers investigated whether immunohistochemistry and multiplexing for collagen type (I & III) and elastic fibers and a modified Victoria blue method could be helpful.
6445212 LZGE6FNP items 1 apa default asc 1
Scientists review cross-sectional studies on dietary habits of patients with nonalcoholic fatty liver disease and randomized controlled trials on the effects of altering dietary macronutrients on intrahepatic triglyceride.
[Nature Reviews Gastroenterology & Hepatology]
6445212 9IDB7M7J items 1 apa default asc 1
Using a combination of well-defined genetically engineered tumor cell lines and canonical small molecule ferroptosis inhibitors, scientists provided unequivocal evidence that sorafenib did not induce ferroptosis in a series of tumor cell lines unlike the cognate system xc− inhibitors sulfasalazine and erastin.
[Cell Death & Disease]
6445212 8FW6G2MA items 1 apa default asc 1
Scientists focused on the regulatory effects of parthenolide, a bioactive component derived from Chrysanthemum parthenium L., against hepatic fibrosis via regulating the crosstalk of toll-like receptor 4 and signal transducer and activator of transcription 3 in activated hepatic stellate cells.
6445212 V7WAZTPQ items 1 apa default asc 1
Scientists developed a single-nucleus RNA-seq2 method tailored for the comprehensive analysis of the nuclear transcriptome from frozen tissues, allowing the dissection of all cell types present in the liver, regardless of cell size or cellular fragility.
6445212 P73BU7CB items 1 apa default asc 1
Scientists identified adenosine deaminases acting on RNA 1 (ADAR1), which was a key factor in Hepatitis B virus evasion from interferon responses in hepatocytes.
[Cellular & Molecular Immunology]
6445212 243C2MRK items 1 apa default asc 1
Researchers detected Yes-associated protein 1 (YAP1) activity in biliary cells and in cells at the hepatobiliary bifurcation in single-cell RNA sequencing analysis of developing livers
6445212 ZHK6ETDW items 1 apa default asc 1
Researchers applied adenine base editors to correct the Z mutation in patient-induced pluripotent stem cells (iPSCs) and iPSC-derived hepatocytes.
6445212 KDV6NIHH items 1 apa default asc 1
In order to evaluate the anti-tumor efficiency and biosafety, the inhibitory rate of HepG2 cells and survival rate of L02 cells were performed in vitro, and the immunohistochemical analysis of H&E, Ki-67, and TUNEL staining were conducted in vivo.
6445212 6MEVB6ZI items 1 apa default asc 1
Can-Fite BioPharma Ltd. announced it has completed preparatory work ahead of the anticipated initiation of patient enrollment for its pivotal Phase III registration trial of Namodenoson in the treatment of hepatocellular carcinoma, the most common form of liver cancer.
[Can-Fite Biopharma Ltd.]
6445212 nan items 1 apa default asc 1