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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
Modeling Immune Lineage Co-Development in Human Pluripotent Stem Cell-derived Liver Organoids
[Journal of Hepatology] The authors generated fetal liver-like organoids from hPSCs to study cross-lineage self-organization by co-developing a hemogenic mesoderm and hepatic endoderm.
NRAV Promotes HCC Stemness via the m6a-Regulated Let-7c-5p/LIN28B Axis
[Cancer Gene Therapy] Investigators identified negative regulator of antiviral response (NRAV) as an m6A-modified lncRNA that promotes HCC stemness through a defined molecular axis.
Hepatic Metabolic Reprogramming in Male Mice during Short-Term Caloric Restriction Involves Enhanced Glucocorticoid Rhythms
[Nature Communications] Scientists showed that in the liver, the glucocorticoid receptor is required for the metabolic response to caloric restriction.
Decoding the CHI3L1/IL-13RĪ±2 Signaling Nexus in MASH-Fibrosis Pathogenesis
[Science Advances] Investigators identified chitinase 3-like 1 (CHI3L1) as a key mediator linking immune activation to fibrotic remodeling in metabolic dysfunction-associated steatohepatitis (MASH).
ATG9A-PLA2G6 Axis Reprograms Phospholipid Metabolism to Drive Metabolic Liver Disease and Hepatocellular Carcinoma
[Autophagy] Using multi-model approaches, the authors demonstrated that liver-specific ATG9A overexpression in mice enhanced autophagic flux but impaired autophagosome degradation.
Identification of an IRF-ZBP1-Caspase-8-NINJ1 Axis in Driving PANoptosis and Pathology during Alcohol-Associated Liver Disease
[Proceedings of The National Academy of Sciences of The United States of America] Researchers identified ZBP1 as the key innate immune sensor responsible for driving ethanol-induced inflammatory cell death, PANoptosis, through caspase-8.
Unveiling EMC6 As a Novel Pathogenic Determinant in Hepatocellular Carcinoma: Orchestration of Lipid Metabolism through Regulation of Lipid Droplet-Associated Enzyme HSD17B13
[Oncogene] Investigators observed the decreased EMC6 expression in human HCC tissues, and diminished expression level of EMC6 was associated with poor prognosis of HCC patients.
Nicotine Exacerbates MASH via Inducing Intestinal Dysbiosis and Barrier Dysfunction
[Communications Biology] Scientists revealed significant intestinal microbiota dysbiosis and upregulated hypoxia-inducible factor 1-alpha levels in nicotine-exposed metabolic dysfunction-associated steatohepatitis (MASH) mice.
Bile Canaliculi Formation in Primary Hepatocytes Requires Ī±1Ī²1 Integrin-Dependent Adherens Junction Re-Organization
[Journal of Cell Science] The authors reported that in primary rat hepatocyte cultures, development and maintenance of a bile canaliculi network requires the repression of contractile substrate-parallel cellācell adhesions near matrix-contacting sites.
Histone Demethylases Regulate Ferroptosis in Metabolic Dysfunction-Associated Steatotic Liver Disease via Epigenetic Modification
[FEBS Journal] Investigators systematically summarize how KDM family members regulate ferroptosis-related gene transcription through epigenetic mechanisms, along with their specific roles in metabolic dysfunction-associated steatotic liver disease progression.
American Liver Foundation Announces $1.1 Million in Liver Disease Research Awards
[American Liver Foundation] American Liver Foundation announced the recipients of its 2025 research awards totaling an historic $1.1M in funding to support early-career scientists, post-doctoral trainees, and junior faculty who are providing cutting-edge research in basic, translational, and clinical projects.
ACBP/DBI Neutralization for the Prevention and Treatment of Malignant and Non-Malignant Liver Diseases
[Cell Death & Disease] The authors discuss current evidence suggesting that the acyl coenzyme A binding protein (ACBP)/diazepam binding inhibitor (DBI) system can be targeted for the prevention or treatment of a wide range of liver diseases.
The publications featured inĀ Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
