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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
JD Bioscience Gains FDA Approval for Phase 2a Clinical Trials on Fatty Liver Drug
[JD Bioscience (ChosunBiz)] The Gwangju Institute of Science and Technology (GIST) noted that the new drug candidate 'GM-60106', developed by JD BioScience, received global clinical Phase IIa trial plan approval from the US FDA.
Beam Therapeutics Announces US FDA Orphan Drug Designation Granted to BEAM-302 for the Treatment of Alpha-1 Antitrypsin Deficiency (AATD)
[Beam Therapeutics] Beam Therapeutics Inc. announced that the US FDA has granted orphan drug designation to BEAM-302, a liver-targeting lipid-nanoparticle formulation of a guide RNA and an mRNA encoding a base editor designed to correct the disease-causing mutation in patients with AATD.
CoQ Imbalance Drives Reverse Electron Transport to Disrupt Liver Metabolism
[Nature] The authors showed that in obesity, hepatic coenzyme Q (CoQ) synthesis is impaired, which increases the CoQH2 to CoQ ratio and drives excessive mROS production through reverse electron transport from site IQ in complex I.
N-Glycosylated LTβR Increases the Th17/Treg Cell Ratio in Liver Cancer by Blocking RORC Ubiquitination and FOXP3 Transcription
[Cell Death & Disease] Researchers employed primary or subcutaneous mouse HCC models and flow cytometry to study the impact of conditional knock-in of Ltbr on CD4+ T cell differentiation and response, particularly the Th17/Treg cell ratio, and its influence on HCC progression.
Targeted Inhibition of Pathobiont Virulence Factor Mitigates Alcohol-Associated Liver Disease
[Cell Host & Microbe] Using metagenomic sequencing of fecal samples from a multicenter, international cohort of patients with alcohol-associated hepatitis, the authors found that the presence of virulence factor KpsM, encoded in the genome of Escherichia coli, correlated with patient mortality.
Hepatocellular Carcinoma Drug Resistance Models
[Cancer Cell International] Investigators searchd PubMed, Embase, and Web of science for studies related to HCC drug resistance models in recent years and systematically summarize the established methods and characteristics of these models
KEAP1 Retention in Phase-Separated P62 Bodies Drives Liver Damage under Autophagy-Deficient Conditions
[EMBO Reports] Scientists showed that excessive Kelch-like ECH-associated protein 1 (KEAP1) retention in p62 bodies and NRF2 activation are major causes of liver damage when autophagy is impaired.
Hepatic Stellate Cells: Balancing Homeostasis, Hepatoprotection and Fibrogenesis in Health, and Disease
[Nature Reviews Gastroenterology & Hepatology] Scientists review how hepatic stellate cells mediators, such as R-spondin 3, hepatocyte growth factor, and bone morphogenetic proteins, regulate critical and homeostatic liver functions in health and disease via cognate receptors in hepatocytes, Kupffer cells, and endothelial cells.
Cellular Crosstalk Mediated by Meteorin-Like Regulating Hepatic Stellate Cell Activation during Hepatic Fibrosis
[Cell Death & Disease] Researchers found that hepatic Meteorin-like mRNA transcripts and protein expression are significantly downregulated in patients and mouse models of hepatic fibrosis.
PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma
[Advanced Science] Investigators reported that phosphatidylinositol 4-phosphate 5-kinase 1 alpha (PIP5K1A) promotes HCC tumorigenesis and predicts poor prognosis in HCC patients.
HBO1 Functions As an Epigenetic Barrier to Hepatocyte Plasticity and Reprogramming during Liver Injury
[Cell Stem Cell] Scientists utilized single-cell chromatin landscape profiling and in vivo genetic screens to characterize the epigenetic basis of hepatocyte-to-biliary epithelial cell conversion.
TATA-Box Binding Protein Associated Factor 2 (TAF2) in Hepatocyte Survival and Tumorigenesis
[Hepatology] The authors explored the role of TATA-box binding protein associated factor 2 (TAF2) in HCC regulation using a hepatocyte-specific conditional knockout mouse, TAF2 knockdown and overexpressing human HCC cells, and TAF2 overexpression in mouse liver by hydrodynamic approach.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
