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Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
A Novel lncRNA-Mediated Signaling Axis Governs Cancer Stemness and Splicing Reprogramming in Hepatocellular Carcinoma with Therapeutic Potential
[Journal of Experimental & Clinical Cancer Research] Investigators performed integrated bulk and single-cell RNA-Seq analyses combined with functional assays to identify key lncRNAs associated with splicing regulation and cancer stemness in HCC.
Discovery of the First-in-Class HSD17B13/PPAR Multitarget Modulators for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis
[Journal of Medicinal Chemistry] Researchers hypothesize that a HSD17B13/PPAR multitarget modulator may have a better effect in targeting multiple pathological mechanisms of metabolic dysfunction-associated steatohepatitis.
GFRAL-Fc Disarms GDF15 to Reprogram Tumor Immunity and Amplify PD-1 Efficacy in Hepatocellular Carcinoma
[Cell Communication and Signaling] Investigators developed a novel growth differentiation factor 15-targeted strategy to improve HCC management and synergize with PD-1 blockade.
The Bcl-2 Family Protein NOXA Is a Novel Regulator of Liver Regeneration
[Life Sciences] Scientists investigated the regulatory role of phorbol-12-myristate-13-acetate-induced protein 1 in liver generation.
POLRMT Enhances Lenvatinib Resistance in Hepatocellular Carcinoma Cells by Maintaining Mitochondrial ATP Production
[Life Sciences] The authors found that POLRMT upregulated in lenvatinib-resistant HCC and is associated with poor patient prognosis.
3D-Bioprinted Liver Cancer Models Derived from Primary Hepatocytes for Simulating Cancer Initiation and Drug Screening
[Hepatology Communications] Scientists established both 2D and 3D models that replicate early HCC progression, offering valuable tools for drug screening and advancing our understanding of early carcinogenic mechanisms.
Humanized Monoacylglycerol Acyltransferase 2 Mice on a High-Fat Diet Exhibit Impaired Liver Detoxification during Metabolic Dysfunction-Associated Steatotic Liver Disease
[PloS One] Researchers examined humanized monoacylglycerol acyltransferase 2 mice and their response to a high-fat diet while investigating hepatocyte dysfunction during obesity development.
Integrated Bioinformatics and Molecular Docking ıDentify CCNB1, CDK1, and CYP1A2 As Therapeutic Targets of Phytochemicals in Hepatocellular Carcinoma
[Naunyn-Schmiedebergs Archives of Pharmacology] Researchers identified potential diagnostic and therapeutic gene targets in HCC through integrated transcriptomic and bioinformatics analyses.
Molecular Network of Metabolic Reprogramming and Precision Diagnosis and Treatment of Hepatocellular Carcinoma
[Biomarker Research] The authors comprehensively integrated recent advances in the understanding of metabolic pathways in HCC, with a particular focus on glycolysis, de novo lipogenesis, and glutamine metabolism.
Linking Necroptosis with Liver Aging and Chronic Inflammation in Hepatic Pathology
[Life Sciences] The authors delve into the complex role of necroptosis in liver aging and chronic liver diseases, detailing the underlying mechanisms and the latest treatment approaches, and underscoring the critical need for extensive research in the area.
Esperion Nominates ESP-2001 as Preclinical Development Candidate for Treatment of Primary Sclerosing Cholangitis
[Esperion] Esperion announced the nomination of ESP-2001, a highly specific allosteric ATP citrate lyase inhibitor, as a preclinical development candidate for the treatment of primary sclerosing cholangitis.
Oncogenic Cholesterol Rewires Lipid Metabolism in Hepatocellular Carcinoma via the CSNK2A1-IGF2R Ser2484 Axis
[Journal of Advanced Research] Scientists investigated the molecular features of alcohol and hepatitis B virus on HCC and sought out potential therapeutic strategies.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
