Hepatic Cell News

Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.

ACBP/DBI Neutralization for the Prevention and Treatment of Malignant and Non-Malignant Liver Diseases

November 28, 2025

[Cell Death & Disease] The authors discuss current evidence suggesting that the acyl coenzyme A binding protein (ACBP)/diazepam binding inhibitor (DBI) system can be targeted for the prevention or treatment of a wide range of liver diseases.

NEK7 Couples SDHB to Orchestrate Respiratory Chain Electron Transport Homeostasis That Impedes Liver Fibrosis

November 28, 2025

[Nature Communications] Researchers found that NIMA-related kinase 7 (NEK7), targeted to mitochondria by its signal peptides, binds to succinate dehydrogenase complex iron sulfur subunit B (SDHB), stabilizing the spatial conformation of complex II and promoting forward electron transport.

Stabilization of FASN by USP5-Mediated Deubiquitination Promotes Hepatocellular Carcinoma Progression

November 28, 2025

[Oncogenesis] Scientists demonstrated that ubiquitin specific peptidase 5 (USP5) expression is significantly elevated in HCC tissues. The overexpression of USP5 was closely associated with larger tumor sizes, more satellite nodules and tumor emboli, and predicted unfavorable clinical outcome in HCC patients as well.

Harnessing Alternative Splicing for Off-the-Shelf mRNA Neoantigen Vaccines in Hepatocellular Carcinoma

November 28, 2025

[Cell Research] Through an integrative analysis of multi-omics data from 279 HCC patients, researchers demonstrated that aberrant splicing events occur at a > 59-fold higher frequency than somatic mutations and generate substantially more immunogenic peptides with broader patient applicability.

Low SVEP1 in Intrahepatic Cholangiocarcinoma Mediates Phenotype Switching-Driven Metastasis by Jag2/Notch1/Hes5

November 28, 2025

[Cell Death & Disease] Investigators examined the role of SVEP1 in intrahepatic cholangiocarcinoma. Downregulated SVEP1 expression promoted ICC cell proliferation, chemotactic migration, and invasion in vitro, as well as tumor growth and lung metastasis in vivo.

New Liver Cancer Blood Test to Make Detection More Effective and Accessible

November 28, 2025

[Curtin University] Liver cancer patients may soon be able to check if their disease has returned with a simple blood test that detects tumor-specific DNA changes in the bloodstream, as part of a new Curtin University-led research project.

Discovery of a Carboxyl Fullerene Derivative As a New Lipid Droplet Regulator Inhibiting MASLD

November 28, 2025

[Gut] Researchers screened biocompatible nanoparticles for anti-metabolic dysfunction-associated steatotic liver disease capacities in vitro by evaluating their regulatory effects on perilipin-2 (PLIN2), the key molecule in lipid droplet formation and stability.

DysUFMylation of SREBP1 Promotes the Progression of Hepatocellular Carcinoma by Reprogramming Lipid Metabolism

November 28, 2025

[Journal of Clinical and Translational Hepatology] Targeting the UFMylation-sterol regulatory element-binding protein 1 (SREBP1) axis, particularly through fatostatin and lenvatinib combination therapy, represents a novel therapeutic strategy for HCC.

Identification of a Common Ketohexokinase-Dependent Link Driving Alcohol Intake and Alcohol-Associated Liver Disease in Mice

November 14, 2025

[Nature Metabolism] The authors investigated whether alcohol preference and alcohol-associated liver disease are mediated through fructose metabolism by ketohexokinase-A/C.

Regenerating Liver Uses Ammonia to Support De Novo Pyrimidine Synthesis and Cell Proliferation

November 14, 2025

[Nature Communications] Scientists found that suppression of de novo pyrimidine synthesis prevents proliferation in regenerating liver, suppressing liver regrowth.

Inhibition of NLRP3 Inflammasome Activation Alleviated Liver Injury and Wasting Effect in Tumor-Bearing Mice

November 14, 2025

[Scientific Reports] RNA-seq data from the liver of Colon26 tumor-bearing mice were used to perform pathway enrichment analysis.

YTHDF1 Mediates KLF2/VSIG4 Axis to Regulate Kupffer Cell Polarization to Alleviate Sepsis-Induced Liver Injury

November 14, 2025

[Genes & Immunity] The effect of YTH domain N6-methyladenosine RNA binding protein F1 (YTHDF1) on Kupffer cell polarization in sepsis was evaluated.

The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!