Using transcriptomics and qPCR analyses in SH-SY5Y neuroblastoma cells, hypothalamic and hippocampal cell line, scientists identified cell type-specific and subfamily member-specific targets for PEA3 transcription factor subfamily.
6807162 WYE69D3M items 1 apa default asc 1
Researchers generated in vitro neurodevelopmental disorder models including human induced pluripotent stem cell based monolayer neuronal differentiation, 3D neuroepithelial bud, and 3D cerebral organoid to study fetal brain development and the potential neuropathological effects induced by the HSV-1 infections.
6807162 SR2928X9 items 1 apa default asc 1
Herpes simplex virus type 1 infection leads to neurodevelopmental disorder-associated neuropathological changes. (n.d.). Retrieved October 23, 2020, from https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008899 Cite
Orbus Therapeutics Inc. announced that it closed an expansion of its Series A financing. The expanded Series A funding will support the ongoing STELLAR study, a Phase III clinical trial studying eflornithine in patients with anaplastic astrocytoma whose cancer has recurred following radiation and adjuvant chemotherapy.
[Orbus Therapeutics Inc.(Globe Newswire, Inc)]
6807162 nan items 1 apa default asc 1
Using a model of cutaneous allergen exposure, investigators showed that allergens directly activated TRPV1+ sensory neurons leading to itch and pain behaviors.
6807162 Z3BF9QAZ items 1 apa default asc 1
Perner, C., Flayer, C. H., Zhu, X., Aderhold, P. A., Dewan, Z. N. A., Voisin, T., Camire, R. B., Chow, O. A., Chiu, I. M., & Sokol, C. L. (2020). Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.10.001 Cite
Scientists profiled microglia differentiated from isogenic, CRISPR-modified TREM2-knockout induced pluripotent stem cell lines.
6807162 X2AT5RFI items 1 apa default asc 1
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease | Nature Communications. (n.d.). Retrieved October 23, 2020, from https://www.nature.com/articles/s41467-020-19227-5 Cite
Researchers describe a method to generate oligodendrocyte precursor cells from human pluripotent stem cells in only ~20 days, which could subsequently myelinate neurons, both in vitro and in vivo.
6807162 P2MQ8AK9 items 1 apa default asc 1
García-León, J. A., García-Díaz, B., Eggermont, K., Cáceres-Palomo, L., Neyrinck, K., Madeiro da Costa, R., Dávila, J. C., Baron-Van Evercooren, A., Gutiérrez, A., & Verfaillie, C. M. (2020). Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells. Nature Protocols, 1–29. https://doi.org/10.1038/s41596-020-0395-4 Cite
MediciNova, Inc.announced that it plans to initiate a multi-center, placebo-controlled, randomized Phase IIb trial to evaluate MN-166 in chemotherapy-induced peripheral neuropathy.
6807162 nan items 1 apa default asc 1
Researchers found that glioblastoma multiforme-cerebrospinal fluid-exosomes (GBM-CSF-Exos) contained a unique protein, LGALS9 ligand, which bound to the TIM3 receptor of dendritic cells (DCs) in the CSF to inhibit antigen recognition, processing and presentation by DCs, leading to failure of the cytotoxic T-cell-mediated antitumor immune response.
[Cell Death & Disease]
6807162 S9R2MXJV items 1 apa default asc 1
The authors discuss how the recently defined functions of these Alzheimer’s disease (AD) risk genes can be targeted therapeutically to modulate microglial cell state and slow the progression of AD.
Scientists showed that three transcription factors, Ascl1, Brn3b, and Isl1, efficiently converted fibroblasts into RGC-like neurons (iRGCs). The competence of cells to enter iRGC reprogramming route was determined by the cell-cycle status at a very early stage of the process.
[Stem Cell Reports]
6807162 8ES4FTS2 items 1 apa default asc 1
The authors report that elevating circulating unacylated-ghrelin, using both pharmacological and genetic methods, reduced hippocampal neurogenesis and plasticity in mice.
[Cell Reports Medicine]
6807162 RDNEEUMH items 1 apa default asc 1
Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson’s Dementia in Humans: Cell Reports Medicine. (n.d.). Retrieved October 22, 2020, from https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(20)30162-2 Cite