NDUFA4L2 Promotes Glioblastoma Progression, Is Associated with Poor Survival, and Can Be Effectively Targeted by Apatinib

Gene knockdown of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 4-like 2 (NDUFA4L2) inhibited tumor cell proliferation and enhanced apoptosis, while tumor cells initiated protective mitophagy in vitro and in vivo.
[Cell Death & Disease]
Chen, Z., Wei, X., Wang, X., Zheng, X., Chang, B., Shen, L., Zhu, H., Yang, M., Li, S., & Zheng, X. (2021). NDUFA4L2 promotes glioblastoma progression, is associated with poor survival, and can be effectively targeted by apatinib. Cell Death & Disease, 12(4), 1–15. https://doi.org/10.1038/s41419-021-03646-3 Cite
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Mutation-Specific Non-Canonical Pathway of PTEN as a Distinct Therapeutic Target for Glioblastoma

Researchers established a library of cancer cell lines that overexpressed mutant proteins using the U87MG and patient-derived cell models lacking functional PTEN.
[Cell Death & Disease]
Choi, S. W., Lee, Y., Shin, K., Koo, H., Kim, D., Sa, J. K., Cho, H. J., Shin, H., Lee, S. J., Kim, H., Chung, S., Shin, J., Lee, C., & Nam, D.-H. (2021). Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma. Cell Death & Disease, 12(4), 1–15. https://doi.org/10.1038/s41419-021-03657-0 Cite
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Astrocytes Close a Motor Circuit Critical Period

Scientists defined a critical period in a developing Drosophila motor circuit and identified astrocytes as essential for proper critical period termination.
[Nature]
Ackerman, S. D., Perez-Catalan, N. A., Freeman, M. R., & Doe, C. Q. (2021). Astrocytes close a motor circuit critical period. Nature, 1–7. https://doi.org/10.1038/s41586-021-03441-2 Cite
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The Autism-Associated Protein CHD8 Is Required for Cerebellar Development and Motor Function

The authors showed that cerebellar granule neuron progenitor-specific deletion of chromodomain helicase DNA-binding protein 8 (CHD8) in mice impaired the proliferation and differentiation of the cells as well as gave rise to cerebellar hypoplasia and a motor coordination defect, but not to autism spectrum disorder-like behavioral abnormalities.
[Cell Reports]
Kawamura, A., Katayama, Y., Kakegawa, W., Ino, D., Nishiyama, M., Yuzaki, M., & Nakayama, K. I. (2021). The autism-associated protein CHD8 is required for cerebellar development and motor function. Cell Reports, 35(1). https://doi.org/10.1016/j.celrep.2021.108932 Cite
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Novel Genome-Editing-Based Approaches to Treat Motor Neuron Diseases: Promises and Challenges

Scientists review genome editing approaches aimed either at correcting the disease-causing mutations or at modulating the expression of genetic modifiers, e.g. by repairing SOD1 mutations or SMN2 splicing defect, or deleting C9orf72 expanded repeats.
[Molecular Therapy]
Miccio, A., Antoniou, P., Ciura, S., & Kabashi, E. (2021). Novel genome-editing-based approaches to treat motor neuron diseases: promises and challenges. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.04.003 Cite
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ERC-USA Announces FDA Recommendation for Early Termination of Phase II Clinical Trial of ERC1671 (Gliovac or Sitoiganap) and Application for Registration Trial for Treatment of Glioblastoma

ERC-USA and the University of California, Irvine has announced that the FDA has recommended early termination of the onging Phase II clinical trial titled ERC1671/GM-CSF/Cyclophosphamide for the treatment of glioblastoma.
[ERC-USA (Globe Newswire, Inc.)]
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ClearPoint Neuro, Inc. Congratulates uniQure on Completion of Enrollment in First Cohort of Phase I/II Clinical Trial of AMT-130 for the Treatment of Huntington’s Disease

ClearPoint Neuro, Inc. congratulated uniQure N.V. on the early completion of patient enrollment in the first dose cohort of a randomized, double-blinded, Phase I/II clinical trial of AMT-130 being conducted in the United States for the treatment of early-stage Huntington’s disease.
[ClearPoint Neuro, Inc.]
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Nitidine Chloride Suppresses Epithelial-Mesenchymal Transition and Stem Cell-Like Properties in Glioblastoma by Regulating JAK2/STAT3 Signaling

Researchers investigated the inhibitory effect of nitidine chloride on the epithelial‐mesenchymal transition process and stem cell‐like properties in glioma cells.
[Cancer Medicine]
Jia, M., Wang, Y., Guo, Y., Yu, P., Sun, Y., Song, Y., & Zhao, L. (n.d.). Nitidine chloride suppresses epithelial-mesenchymal transition and stem cell-like properties in glioblastoma by regulating JAK2/STAT3 signaling. Cancer Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/cam4.3869 Cite
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C3G Downregulation Induces the Acquisition of a Mesenchymal Phenotype That Enhances Aggressiveness of Glioblastoma Cells

The authors report that C3G downregulation promoted the acquisition of a more mesenchymal phenotype that enhanced the migratory and invasive capacity of glioblastoma cells.
[Cell Death & Disease]
Manzano, S., Gutierrez-Uzquiza, A., Bragado, P., Sequera, C., Herranz, Ó., Rodrigo-Faus, M., Jauregui, P., Morgner, S., Rubio, I., Guerrero, C., & Porras, A. (2021). C3G downregulation induces the acquisition of a mesenchymal phenotype that enhances aggressiveness of glioblastoma cells. Cell Death & Disease, 12(4), 1–17. https://doi.org/10.1038/s41419-021-03631-w Cite
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Incorporation of a Nucleoside Analog Maps Genome Repair Sites in Postmitotic Human Neurons

A targeted sequencing approach in human embryonic stem cell–induced neurons showed that, in neurons, DNA repair is enriched at well-defined hotspots that protect essential genes.
[Science]
Reid, D. A., Reed, P. J., Schlachetzki, J. C. M., Nitulescu, I. I., Chou, G., Tsui, E. C., Jones, J. R., Chandran, S., Lu, A. T., McClain, C. A., Ooi, J. H., Wang, T.-W., Lana, A. J., Linker, S. B., Ricciardulli, A. S., Lau, S., Schafer, S. T., Horvath, S., Dixon, J. R., … Gage, F. H. (2021). Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons. Science, 372(6537), 91–94. https://doi.org/10.1126/science.abb9032 Cite
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Dynamic Spatiotemporal Coordination of Neural Stem Cell Fate Decisions Occurs through Local Feedback in the Adult Vertebrate Brain

The authors combined dynamic imaging of entire neural stem cell (NSC) populations in their in vivo niche over several weeks with pharmacological manipulations, mathematical modeling, and spatial statistics and demonstrated that NSCs use spatiotemporally resolved local feedback signals to coordinate their decision to divide in adult zebrafish brains.
[Cell Stem Cell]
Dray, N., Mancini, L., Binshtok, U., Cheysson, F., Supatto, W., Mahou, P., Bedu, S., Ortica, S., Than-Trong, E., Krecsmarik, M., Herbert, S., Masson, J.-B., Tinevez, J.-Y., Lang, G., Beaurepaire, E., Sprinzak, D., & Bally-Cuif, L. (2021). Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.03.014 Cite
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