m6A Reader IGF2BP2-Stabilized CASC9 Accelerates Glioblastoma Aerobic Glycolysis by Enhancing HK2 mRNA Stability

MeRIP-Seq revealed the m6A profile in the glioblastoma multiforme (GBM). Moreover, the m6A-related long non-coding RNA CASC9 expression was significantly elevated in the GBM tissue and its ectopic high expression was associated with poor survival, acting as an independent prognostic factor for GBM patients.
[Cell Death Discovery]
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Viability Fingerprint of Glioblastoma Cell Lines: Roles of Mitotic, Proliferative, and Epigenetic Targets

Scientists compared the efficacy of focused modulation of a set of signaling pathways in two glioblastoma cell lines, U-251 MG and T98-G, using a panel of thirteen compounds targeting cell cycle progression, proliferation, epigenetic modifications, and DNA repair mechanism.
[Scientific Reports]
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Disturbance of Phylogenetic Layer-Specific Adaptation of Human Brain Gene Expression in Alzheimer’s Disease

Scientists identified Alzheimer’s disease (AD)-associated layer-specific differences involving protein-coding and non-coding sequences, most of those present in the subcortical white matter, thus indicating a critical role for long axons and oligodendrocytes in AD pathomechanism.
[Scientific Reports]
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The Polarity Protein Par3 Coordinates Positively Self-Renewal and Negatively Invasiveness in Glioblastoma

Researchers studied the role of the Par3 protein (encoded by PARD3) in glioblastoma multiforme (GBM). GBM patient transcriptomic data and patient-derived culture analysis indicated diverse levels of expression of PARD3 across and independent from subtypes
[Cell Death & Disease]
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Downregulation of Phosphoglycerate Mutase 5 Improves Microglial Inflammasome Activation after Traumatic Brain Injury

Researchers evaluated the effects of Pgam5 on neurological deficits and neuroinflammation of controlled cortical impact-induced TBI mouse model in vivo and LPS+ ATP-induced microglia model in vitro.
[Cell Death Discovery]
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Synapse Development Is Regulated by Microglial THIK-1 K+ Channels

Microglial ramification, motility, and cytokine release are regulated by tonically active THIK-1 K+ channels on the microglial plasma membrane. Researchers examined whether these channels played a role in phagocytosis.
[Proceedings of the National Academy of Sciences of the United States of America]
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Recruitment and Inhibitory Action of Hippocampal Axo-Axonic Cells during Behavior

Scientists achieved cell-type-specific genetic access to axo-axonic cells (AACs) in mice and showed that AACs in the hippocampal area CA1 were synchronously activated by episodes of locomotion or whisking during rest.
[Neuron]
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Development of Prefrontal Cortex

An understanding of the development and evolution of the PFC provide insight into the pathogenesis and treatment of congenital neuropsychiatric diseases as well as idiopathic developmental disorders that cause intellectual disabilities.
[Neuropsychopharmacology]
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Otsuka and Lundbeck Announce FDA Acceptance of Supplemental New Drug Application; Receive Priority Review for Treatment of Schizophrenia in Adolescents

Otsuka Pharmaceutical Co., Ltd. and H. Lundbeck A/S reported that the US FDA has accepted a Supplemental New Drug Application for the treatment of schizophrenia in adolescents with Rexulti® and has granted Otsuka and Lundbeck Priority Review.
[Otsuka Pharmaceutical Co., Ltd. (BusinessWire, Inc.)]
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Pyrvinium Pamoate Regulates MGMT Expression through Suppressing the Wnt/β-Catenin Signaling Pathway to Enhance the Glioblastoma Sensitivity to Temozolomide

Investigators found that pyrvinium pamoate (PP) and Temozolomide (TMZ) had synergistic effect on inhibiting the viability of glioblastoma multiforme (GBM) cells, and PP induced inhibition of MGMT and enhanced the TMZ chemosensitivity of GBM cells through down-regulating Wnt/β-catenin pathway.
[Cell Death Discovery]
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Interventional Strategies for Parkinson Disease: Can Neural Precursor Cells Forge a Path Ahead?

The authors discuss the role of PSC-derived neural precursor cells in rat models of MPTP-induced Parkinson’s disease following intranasal injections.
[ACS Chemical Neuroscience]
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