Immunogenic Cell Death and Its Therapeutic or Prognostic Potential in High-Grade Glioma

Glioblastoma (GBM) is the most lethal primary brain tumor with a dismal prognosis despite maximal therapy. The development of new therapies in this aggressive type of tumors remains highly challenging partially due to the cold tumor immune environment. GBM could therefore benefit from immunogenic cell death-based therapies stimulating the anti-tumor immune response.
[Genes & Immunity]
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Pharmacological Brain Cytoprotection in Acute Ischaemic Stroke — Renewed Hope in the Reperfusion Era

Scientists review new types of clinical trials to evaluate whether cytoprotective drugs can slow infarct growth prior to reperfusion and/or ameliorate the consequences of reperfusion, such as haemorrhagic transformation.
[New England Journal of Medicine]
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Midbrain Organoids Mimic Early Embryonic Neurodevelopment and Recapitulate LRRK2-p.Gly2019Ser-Associated Gene Expression

The authors compared single-cell RNA-sequencing data of human midbrain organoids to the developing human embryonic midbrain.
[American Journal of Human Genetics]
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Reaching into the Toolbox: Stem Cell Models to Study Neuropsychiatric Disorders

Investigators discussed available tools, including CRISPR-Cas9, and the applications of these tools to develop cell-based 2D models and 3D brain organoid models that better represent and unravel the intricacies of neuropsychiatric disorder pathophysiology.
[Stem Cell Reports]
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Expression of the Transcription Factor PU.1 Induces the Generation of Microglia-Like Cells in Human Cortical Organoids

The authors developed a method to generate functional microglia in human cortical organoids from human embryonic stem cells.
[Nature Communications]
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Androgens Increase Excitatory Neurogenic Potential in Human Brain Organoids

Investigators used brain organoids to show that although sex chromosomal complement had no observable effect on neurogenesis, sex steroids—namely androgens—led to increased proliferation of cortical progenitors and an increased neurogenic pool.
[Nature]
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Orbus Therapeutics’ Phase III Eflornithine STELLAR Study Reaches Full Patient Enrollment

Orbus Therapeutics, Inc. announced that patient enrollment of its Phase III STELLAR clinical study of eflornithine in patients with recurrent anaplastic astrocytoma is complete. The STELLAR study completed full enrollment with a total of 343 patients.
[Orbus Therapeutics, Inc.]
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AI Therapeutics Announces Initiation of a Phase II Clinical Trial of AIT-101 for Treatment of ALS

AI Therapeutics, Inc., a clinical-stage biopharmaceutical company developing novel therapeutics for rare diseases, announced the initiation of a Phase II study for a promising new approach to treat ALS.
[AI Therapeutics, Inc.]
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EIF4A3-Induced circCCNB1 (hsa_circ_0001495) Promotes Glioma Progression by Elevating CCND1 through Interacting miR-516b-5p and HuR

CircRNA cyclin B1 (circCCNB1) knockdown reduced cyclin D1 (CCND1) expression in glioma cells and CCND1 overexpression bated the effect of circCCNB1 knockdown on glioma cell growth.
[Metabolic Brain Disease]
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Astrocytes Display Cell Autonomous and Diverse Early Reactive States in Familial Amyotrophic Lateral Sclerosis

The authors revealed that reactive transformation can occur cell autonomously in human ALS astrocytes and with a striking degree of early molecular and functional heterogeneity when comparing different disease-causing mutations.
[Brain]
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Chemokine CCL18 Promotes Phagocytosis Through Its Receptor CCR8 Rather than PITPNM3 in Human Microglial Cells

Investigators showed that CCL18 did not change the expression of the inflammatory factors, interleukin (IL)-1β, IL-6, tumor necrosis factor alpha, or inducible nitric oxide synthase, but significantly induced expression of the macrophage markers, MRC-1 and ARG-1 M2, in a human microglial clone 3 cell line
[Journal of Interferon and Cytokine Research]
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