ADAMTS1 Supports Endothelial Plasticity of Glioblastoma Cells with Relevance for Glioma Progression

The authors performed an in silico study of ADAMTS1 and endothelial markers in human gliomas, providing the basis to further assess these molecules in several primary glioblastoma-initiating cells and established glioblastoma cells with the ability to acquire an endothelial-like phenotype.
[Biomolecules]
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Glioma Stem Cells and Their Roles within the Hypoxic Tumor Microenvironment

Investigators summarize the impact of hypoxia and acidic stress on glioma stem cell signaling and biologic phenotypes, and potential methods to inhibit these pathways.
[Theranostics]
Boyd, N. H., Tran, A. N., Bernstock, J. D., Etminan, T., Jones, A. B., Gillespie, G. Y., Friedman, G. K., & Hjelmeland, A. B. (2021). Glioma stem cells and their roles within the hypoxic tumor microenvironment. Theranostics, 11(2), 665–683. https://doi.org/10.7150/thno.41692 Cite
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Targeting of Glioma Stem-Like Cells with a Parthenolide Derivative ACT001 through Inhibition of AEBP1/PI3K/AKT Signaling

The effects of ACT001 on cell survival of normal human astrocytes and patient-derived glioma stem-like cells were evaluated. RNA-Seq were performed to detect differentially expressed genes.
[Theranostics]
Hou, Y., Sun, B., Liu, W., Yu, B., Shi, Q., Luo, F., Bai, Y., & Feng, H. (2021). Targeting of glioma stem-like cells with a parthenolide derivative ACT001 through inhibition of AEBP1/PI3K/AKT signaling. Theranostics, 11(2), 555–566. https://doi.org/10.7150/thno.49250 Cite
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STING Controls Nociception via Type I Interferon Signaling in Sensory Neurons

Investigators demonstrated that STING was a critical regulator of nociception through type-I interferon signaling in peripheral nociceptive sensory neurons.
[Nature]
Donnelly, C. R., Jiang, C., Andriessen, A. S., Wang, K., Wang, Z., Ding, H., Zhao, J., Luo, X., Lee, M. S., Lei, Y. L., Maixner, W., Ko, M.-C., & Ji, R.-R. (2021). STING controls nociception via type I interferon signalling in sensory neurons. Nature, 1–6. https://doi.org/10.1038/s41586-020-03151-1 Cite
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An Alternative Approach To Produce Versatile Retinal Organoids with Accelerated Ganglion Cell Development

Scientists describe and characterized a protocol focused on the generation of retinal ganglion cells within an accelerated four week timeframe without any external small molecules or growth factors.
[Scientific Reports]
Wagstaff, P. E., ten Asbroek, A. L. M. A., ten Brink, J. B., Jansonius, N. M., & Bergen, A. A. B. (2021). An alternative approach to produce versatile retinal organoids with accelerated ganglion cell development. Scientific Reports, 11(1), 1101. https://doi.org/10.1038/s41598-020-79651-x Cite
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MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration

Researchers observed that monocarboxylate transporter 1 (MCT1) loss from oligodendrocyte lineage cells was dispensable for normal myelination and axonal energy homeostasis early in life.
[Cell Reports]
Philips, T., Mironova, Y. A., Jouroukhin, Y., Chew, J., Vidensky, S., Farah, M. H., Pletnikov, M. V., Bergles, D. E., Morrison, B. M., & Rothstein, J. D. (2021). MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration. Cell Reports, 34(2). https://doi.org/10.1016/j.celrep.2020.108610 Cite
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Multiple Signaling Pathways Are Essential for Synapse Formation Induced by Synaptic Adhesion Molecules

To explore what signaling pathways may be involved, investigators employed heterologous synapse formation assays in which a synaptic adhesion molecule expressed in a nonneuronal cell induced pre- or postsynaptic specializations in cocultured neurons.
[Proceedings of the National Academy of Sciences of the United States of America]
Jiang, X., Sando, R., & Südhof, T. C. (2021). Multiple signaling pathways are essential for synapse formation induced by synaptic adhesion molecules. Proceedings of the National Academy of Sciences, 118(3). https://doi.org/10.1073/pnas.2000173118 Cite
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Cognito Therapeutics Receives FDA Breakthrough Device Designation for Next-Generation Digital Therapeutic in Alzheimer’s Disease

Cognito Therapeutic. Inc. announced its lead product has received Breakthrough Device Designation from the FDA for the treatment of cognitive and functional symptoms associated with Alzheimer’s disease.
[Cognito Therapeutic. Inc. (Business Wire, Inc.)]
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New Treatment for Central Nervous System Tumors Enters Phase I Clinical Trials

OX2 Therapeutics, Inc. announced that they treated their first patient in a Phase I human trial of a new treatment developed to combat recurrent high-grade brain tumors.
[OX2 Therapeutics, Inc. (Business Wire, Inc.)]
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Altered Hippocampal Gene Expression, Glial Cell Population, and Neuronal Excitability in Aminopeptidase P1 Deficiency

The authors showed that a deficiency of aminopeptidase P1 modified the glial population and neuronal excitability in the hippocampus.
[Scientific Reports]
Yoon, S. H., Bae, Y.-S., Oh, S. P., Song, W. S., Chang, H., & Kim, M.-H. (2021). Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency. Scientific Reports, 11(1), 932. https://doi.org/10.1038/s41598-020-79656-6 Cite
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Neuroinvasion of SARS-CoV-2 in Human and Mouse Brain

Scientists used three independent approaches to probe the capacity of SARS-CoV-2 to infect the brain. Using human brain organoids, they observed clear evidence of infection with accompanying metabolic changes in infected and neighboring neurons.
[Journal of Experimental Medicine]
Song, E., Zhang, C., Israelow, B., Lu-Culligan, A., Prado, A. V., Skriabine, S., Lu, P., Weizman, O.-E., Liu, F., Dai, Y., Szigeti-Buck, K., Yasumoto, Y., Wang, G., Castaldi, C., Heltke, J., Ng, E., Wheeler, J., Alfajaro, M. M., Levavasseur, E., … Iwasaki, A. (2021). Neuroinvasion of SARS-CoV-2 in human and mouse brain. Journal of Experimental Medicine, 218(e20202135). https://doi.org/10.1084/jem.20202135 Cite
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