The authors discuss recent advances on nonconventional ubiquitin chains in neural development, function, plasticity, and related pathologies.
The authors showed that core pluripotency factors OCT4 and SOX2 suppress chaperone-mediated autophagy, a selective form of autophagy, until the initiation of differentiation.
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Scientists showed that transgene expression enhancement was mediated by transcriptional activation of endogenous human MSC genes by the cytosolic glucocorticoid receptor.
[Molecular Therapy-Methods & Clinical Development]
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Hamann, A., Kozisek, T., Broad, K., & Pannier, A. K. (2020). Glucocorticoid Priming of Nonviral Gene Delivery to Human Mesenchymal Stem Cells Increases Transfection by Reducing Induced Stresses. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2020.07.014 Cite
Scientists found that zeta inhibitory peptide induced redistribution of the AMPARGluA1 in HEK293 cells and primary cortical neurons, and decreased AMPAR-mediated currents in the nucleus accumbens.
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Researchers identified the key gene signatures and pathways associated with TTFields in four glioblastoma cell lines varying in TP53 mutation status using gene profiling and functional annotation.
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Investigators found that the paired‐less PAX 6, PAX 6D, was expressed in neural retina cells during human eye development and along human embryonic stem cell specification to retinal cells.
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Human umbilical cord (hUC)-MSCs were administered into chronic unpredictable mild stress model mice through the tail vein once a week for four weeks. After the administration of hUC-MSCs, the depression-like and anxiety-like phenotypes, neuronal histopathology, synaptic-related protein expression and inflammatory index of the mice were assessed.
[Brain Research Bulletin]
The authors used a combination of imaging, single cell, and surgical approaches to identify a CD69+ CD4 T cell population in both the mouse and human brain, distinct from circulating CD4 T cells.
For the hundreds of thousands of people enrolling in clinical trials every year—and for whom experimental therapies can offer a last hope—a new report provides some welcome news: Enrollment in clinical studies in the United States is on the rebound after disruptions caused by the COVID-19 pandemic.
CytRx Corporation highlighted that Orphayzme A/S announced it will join The Michael J. Fox Foundation’s Parkinson’s Disease Research Tools Consortium.
A historic €1.8-trillion (US$2.1-trillion) budget deal reached by European Union (EU) leaders to fund its next seven years — and its recovery from the coronavirus pandemic — has left scientists and research advocates disappointed.
Reserachers explored the mechanisms underlying axon growth in three dimensions. They found that CNS neurons used amoeboid mechanisms to drive axon growth.