Team Science for Groundbreaking Fundamental Research Receives Boost of 12.5 Million Euros

With a view to team science, the programme ZonMw Open Competition is specifically aimed at innovative and groundbreaking combinations of two or more research groups.
[ZonMw]
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IN8bio Completes Treatment of First Cohort in Phase I Clinical Trial with Gamma Delta T-Cell Therapy in Patients with Newly Diagnosed Glioblastoma Multiforme

IN8bio, Inc. announced an update from the ongoing Phase I clinical trial of INB-200, its DeltEx drug resistant immunotherapy , MGMT-gene modified gamma delta T-cells in patients with newly diagnosed GBM.
[IN8bio, Inc.]
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Bayer to Advance Two First-of-Its-Kind Investigational Cell and Gene Therapies for Parkinson’s Disease

Bayer AG announced that BlueRock Therapeutics successfully administered the first dose of its investigational pluripotent stem cell-derived dopaminergic neurons, named DA01, to a Parkinson’s disease patient in their open-label Phase I clinical safety and tolerability study.
[Bayer AG (BusinessWire, Inc.)]
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IGC Completes Cohort II of Its Phase I THC-Based Clinical Trial on Alzheimer’s Patients

India Globalization Capital, Inc. (IGC) announced that it has completed Cohort II of its Phase I clinical trial on IGC’s tetrahydrocannabinol-based investigational new drug, IGC-AD1, intended to alleviate the symptoms of individuals suffering from Alzheimer’s disease.
[India Globalization Capital, Inc. (BusinessWire, Inc.)]
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Epigenomic Landscape and 3D Genome Structure in Pediatric High-Grade Glioma

To investigate whether H3K27M was associated with distinct chromatin structure that altered transcription regulation, investigators generated the first high-resolution genome structure maps of pediatric high-grade gliomas cell lines and tumor tissue.
[Science Advances]
Wang, J., Huang, T. Y.-T., Hou, Y., Bartom, E., Lu, X., Shilatifard, A., Yue, F., & Saratsis, A. (2021). Epigenomic landscape and 3D genome structure in pediatric high-grade glioma. Science Advances, 7(23), eabg4126. https://doi.org/10.1126/sciadv.abg4126 Cite
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Synergistic Immunotherapy of Glioblastoma by Dual Targeting of IL-6 and CD40

Researchers identified a Stat3/HIF-1α-mediated axis, through which IL-6 executed an anti-tumor role to induce CD40 expression in Mϕs.
[Nature Communications]
Yang, F., He, Z., Duan, H., Zhang, D., Li, J., Yang, H., Dorsey, J. F., Zou, W., Ali Nabavizadeh, S., Bagley, S. J., Abdullah, K., Brem, S., Zhang, L., Xu, X., Byrne, K. T., Vonderheide, R. H., Gong, Y., & Fan, Y. (2021). Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Nature Communications, 12(1), 3424. https://doi.org/10.1038/s41467-021-23832-3 Cite
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Nucleocytoplasmic Transport of the RNA-Binding Protein CELF2 Regulates Neural Stem Cell Fates

In self-renewing neural stem/progenitor cells, CELF2 resided in the cytoplasm, where it repressed mRNAs encoding cell fate regulators and neurodevelopmental disorder-related factors.
[Cell Reports]
MacPherson, M. J., Erickson, S. L., Kopp, D., Wen, P., Aghanoori, M.-R., Kedia, S., Burns, K. M. L., Vitobello, A., Mau-Them, F. T., Thomas, Q., Gold, N. B., Brucker, W., Amlie-Wolf, L., Gripp, K. W., Bodamer, O., Faivre, L., Muona, M., Menzies, L., Baptista, J., … Yang, G. (2021). Nucleocytoplasmic transport of the RNA-binding protein CELF2 regulates neural stem cell fates. Cell Reports, 35(10). https://doi.org/10.1016/j.celrep.2021.109226 Cite
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Replicative Senescence Dictates the Emergence of Disease-Associated Microglia and Contributes to Aβ Pathology

Researchers aimed to understand the long-term impact of the early and prolonged microglial proliferation observed in Alzheimer’s disease, hypothesizing that extensive and repeated cycling would engender a distinct transcriptional and phenotypic trajectory.
[Cell Reports]
Hu, Y., Fryatt, G. L., Ghorbani, M., Obst, J., Menassa, D. A., Martin-Estebane, M., Muntslag, T. A. O., Olmos-Alonso, A., Guerrero-Carrasco, M., Thomas, D., Cragg, M. S., & Gomez-Nicola, D. (2021). Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology. Cell Reports, 35(10). https://doi.org/10.1016/j.celrep.2021.109228 Cite
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Small Molecule 1a Reduces FMRpolyG-Mediated Toxicity in In Vitro and In Vivo Models for FMR1 Premutation

Scientists presented for the first time primary hippocampal neurons derived from the ubiquitous inducible mouse model used as a screening tool for targeted interventions.
[Human Molecular Genetics]
Haify, S. N., Buijsen, R. A. M., Verwegen, L., Severijnen, L.-A. W. F. M., de Boer, H., Boumeester, V., Monshouwer, R., Yang, W. Y., Cameron, M. D., Willemsen, R., Disney, M. D., & Hukema, R. K. (2021). Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation. Human Molecular Genetics, ddab143. https://doi.org/10.1093/hmg/ddab143 Cite
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Convergent NMDA Receptor—Pannexin1 Signaling Pathways Regulate the Interaction of CaMKII with Connexin-36

To explain the molecular mechanism of how Cx36 modified plasticity at gap junctions, researchers investigated the roles of ionotropic N-methyl-D-aspartate receptors and pannexin1 channels in regulating Cx36 binding toCa2+/calmodulin-dependent protein kinase II (CaMKII).
[Communications Biology]
Siu, R. C. F., Kotova, A., Timonina, K., Zoidl, C., & Zoidl, G. R. (2021). Convergent NMDA receptor—Pannexin1 signaling pathways regulate the interaction of CaMKII with Connexin-36. Communications Biology, 4(1), 1–14. https://doi.org/10.1038/s42003-021-02230-x Cite
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H2S Protects Hippocampal Neurons against Hypoxia-Reoxygenation Injury by Promoting RhoA Phosphorylation at Ser188

Reserachers investigated the target and mechanism of H2S in inhibition of RhoA/ROCK. GST-RhoAwild and GST-RhoAS188A proteins were constructed and expressed, and were used for phosphorylation assay in vitro.
[Cell Death Discovery]
Chen, Y., Wen, J., & Chen, Z. (2021). H2S protects hippocampal neurons against hypoxia-reoxygenation injury by promoting RhoA phosphorylation at Ser188. Cell Death Discovery, 7(1), 1–15. https://doi.org/10.1038/s41420-021-00514-z Cite
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