Targeting EYA2 Tyrosine Phosphatase Activity in Glioblastoma Stem Cells Induces Mitotic Catastrophe

The authors interrogated gene expression profiles from glioblastoma stem cells, differentiated glioblastoma cells, and neural stem cells, revealing EYA2 as preferentially expressed by GSCs.
[Journal of Experimental Medicine]
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DHHC9-Mediated GLUT1 S-Palmitoylation Promotes Glioblastoma Glycolysis and Tumorigenesis

Scientists found that GLUT1 was palmitoylated at Cys207, and S-palmitoylation was required for maintaining GLUT1 PM localization. They identified DHHC9 as the palmitoyl transferase responsible for this critical posttranslational modification.
[Nature Communications]
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TRIP6 Functions in Brain Ciliogenesis

TRIP6 carries numerous protein interaction domains and its functions require homodimerization. TRIP6 disruption in vitro, via RNAi or inhibition of its homodimerization, confirmed its function in ciliogenesis.
[Nature Communications]
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ATP-Citrate Lyase Promotes Axonal Transport across Species

Researchers showed that Acly expression was reduced upon loss of Elongator activity, further connecting Elongator to Atat1 in a pathway regulating α-tubulin acetylation and MT-dependent transport in projection neurons, across species.
[Nature Communications]
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Epigenetic Encoding, Heritability and Plasticity of Glioma Transcriptional Cell States

Investigators demonstrated heritability of malignant cell states, with key differences in hierarchal and plastic cell state architectures in IDH-mutant glioma versus IDH-wild-type glioblastoma, respectively.
[Nature Genetics]
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Circuit-Specific Enteric Glia Regulate Intestinal Motor Neurocircuits

Scientists combined glial chemogenetics with genetically encoded calcium indicators expressed in enteric neurons and glia to study network-level activity in the intact myenteric plexus of the proximal colon.
[Proceedings of the National Academy of Sciences of the United States of America]
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Genetic Targeting of Adult Renshaw Cells Using a Calbindin 1 Destabilized Cre Allele for Intersection with Parvalbumin or Engrailed1

Renshaw cells (RCs) are one of the most studied spinal interneurons; however, their roles in motor control remain enigmatic in part due to the lack of experimental models to interfere with RC function, specifically in adults. Scientists leveraged the distinct temporal regulation of Calbindin expression in RCs to create genetic models for timed RC manipulation.
[Scientific Reports]
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Activators of Alpha Synuclein Expression Identified by Reporter Cell Line-Based High Throughput Drug Screen

Scientists identified specific modulators of alpha synuclein gene (SNCA) transcription, generated CRISPR/Cas9 modified SNCA-GFP-luciferase genomic fusion- and control cell lines and screened a library of 1649 bioactive compounds, including the FDA approved drugs.
[Scientific Reports]
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Astrocytic YAP Prevents the Demyelination through Promoting Expression of Cholesterol Synthesis Genes in Experimental Autoimmune Encephalomyelitis

Researchers found that YAP was upregulated and activated in astrocytes of spinal cords of encephalomyelitis mice through suppression of the Hippo pathway.
[Cell Death & Disease]
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Astrocytic Microdomains from Mouse Cortex Gain Molecular Control over Long-Term Information Storage and Memory Retention

Scientists demonstrated that persistent synaptic strengthening invited astrocytic microdomains to convert initially internalized (pro)-brain-derived neurotrophic factor into active prodomain and mature BDNF for synaptic re-use.
[Communications Biology]
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Sunshine Biopharma Files a Patent Application Covering mRNA Molecules for Treatment of Neurodegenerative Diseases

Sunshine Biopharma, Inc. announced that it has filed a patent application for a potential new treatment for neurodegenerative disorders. Sunshine Biopharma’s patent application contains experimental results showing that certain mRNA molecules provide protective effects against oxidative stress in differentiated neuronal cells, a process that mimics neuronal degeneration.
[Sunshine Biopharma Inc.]
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