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Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
De Novo Designed Voltage-Gated Anion Channels Suppress Neuron Firing
[Cell] The authors reported the accurate de novo design of voltage-gated anion channels, namely dVGACs. dVGACs adopt a 15-helix pentameric architecture featuring arginine constrictions within the transmembrane span and show voltage-dependent anions currents in patch-clamp experiments.
Galnt2 Neurons in the Ventromedial Hypothalamus Counterregulate Hypoglycemia via a Brain-Liver Neurocircuit
[Cell Metabolism] Researchers identified a biphasic pattern in blood and hypothalamic glucose dynamics during prolonged fasting, revealing an additional threshold-dependent mechanism for counterregulation.
Transcriptional and Epigenetic Targets of MEF2C in Human Microglia Contribute to Cellular Functions Related to Autism Risk and Age-Related Disease
[Nature Immunology] To examine disease-associated functions of MEF2C in human microglia, we profiled microglia differentiated from isogenic MEF2C-haploinsufficient and MEF2C-knockout iPSC lines.
NIH Grant Awarded to Further Research of Novel Chemical Pathway to Reverse MCI
[Posit Science] The NIH has awarded a new grant to Posit Science to advance research, which showed in a neuro-imaging study, that their brain exercises can significantly upregulate the production of acetylcholine.
TDP-43 Loss Induces Cryptic Polyadenylation in ALS/FTD
[Nature Neuroscience] Researchers developed a bioinformatic pipeline to reliably identify alternative last exons, 3’ untranslated region extensions and intronic polyadenylation APA event types, and they identified cryptic alternative polyadenylation sites induced by TDP-43 loss in iPSC-derived neurons.
TDP-43 Nuclear Loss in FTD/ALS Causes Widespread Alternative Polyadenylation Changes
[Nature Neuroscience] Investigators showed that loss of TDP-43 from neuronal nuclei of human brain and disease-causing mutations in TDP-43 are associated with widespread changes in alternative polyadenylation.
Neuronal Plasticity at Puberty in Mouse Hypothalamic Kiss1 Neurons That Control Fertility
[Proceedings of The National Academy of Sciences of The United States of America] Scientists showed that during a critical window at the start of puberty, estrogen drives changes in the electrical properties of neurons that release kisspeptin.
HIF2α Negatively Regulates MYCN Protein Levels and Promotes a Low-Risk Noradrenergic Phenotype in Neuroblastoma
[Proceedings of The National Academy of Sciences of The United States of America] Investigators showed that induced expression of HIF2α in MYCN-amplified neuroblastoma substantially reduces MYCN protein levels and attenuates proliferation while it induces several features of noradrenergic differentiation and impedes xenograft tumor growth.
Redefining Dopaminergic Synapses beyond the Classical Paradigm
[Trends In Neurosciences] Scientists discuss how recent findings have reshaped current understanding of dopamine vesicles, revealing a structural continuum that includes non-classical architectures.
Phase I/IIa Clinical Trial of hESC-Derived Dopamine Progenitors in Parkinson’s Disease
[Cell] Scientists generated high-purity dopaminergic progenitors from hESCs and evaluated their safety and exploratory efficacy in a single-center, open-label, dose-escalation Phase I/IIa trial for Parkinson's disease patients.
Parkinson’s Treatment Tested at UW Showing Promise in First Clinical Trial
[University of Wisconsin–Madison] Parkinson’s patients are receiving a new investigational treatment after a successful study at the University of Wisconsin–Madison (UW) helped demonstrate the cell therapy’s safety in non-human primates and refine the method for its delivery.
McGill Researchers Win Brain Canada’s Future Leaders in Canadian Brain Research Award
[McGill University] Jérôme Fortin, Paul Masset, and Simon Thebault have received the Future Leaders in Canadian Brain Research Award from Brain Canada for their research in brain cognition, brain cancer, and neurological disabilities.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
