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Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
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TSC Tunes Progenitor Balance and Upper-Layer Neuron Generation in Neocortex
[Nature] Researchers showed that members of the tuberous sclerosis complex (TSC), proteins that are major regulators of cellular metabolism, function to sculpt radial progenitor–intermediate progenitor balance, radial unit organization, and the resultant generation of upper-layer neurons.
Characteristics and Mechanisms of Cognitive Impairment in Parkinson Disease
[Nature Reviews Neurology] A deeper understanding of the multifaceted pathophysiology of Parkinson disease (PD)-associated cognitive impairment will help to explain the heterogeneity of cognitive profiles and disease progression in PD, providing a foundation for personalized disease-modifying treatments.
Pioglitazone Modulates Metabolic Adaptation and Peripheral Nerve Regeneration after Injury
[Molecular Neurodegeneration] Scientists investigated peroxisome proliferator-activated receptor gamma as a therapeutic target in the context of nerve regeneration, since they previously found this transcription factor to be involved in Schwann cell reprograming and metabolic adaptations.
Genetic Factors and Comorbid Pathologies Interact to Drive Regional Mitophagy Alterations in Lewy Body Dementia
[Acta Neuropathologica] Investigators revealed complex interactions between Lewy body pathology, neurofibrillary tangle pathology, and genetic mitophagy modifiers in Lewy body disease brains, highlighting potential convergent molecular mechanisms underlying α-synuclein- and tau-associated mitophagy alterations.
DAP12 Deletion Reduces Neuronal SLIT2 and Demyelination and Enhances Brain Resilience in Female Tauopathy Mice
[Molecular Neurodegeneration] Scientists investigated the effects of DNAX-activation protein 12 DAP12 deletion on tau pathology, as well as tau-induced brain inflammation and neurodegeneration, in homozygous human Tau P301S transgenic mice.
ALDH2 Protects against Dopaminergic Neuronal Cell Ferroptosis by Enhancing the Enzyme Activity of PRDX6 in Parkinson’S Disease
[NPJ Parkinson'S Disease] Acetaldehyde dehydrogenase 2 (ALDH2) knockout mice were more susceptible to the loss of tyrosine hydroxylase-positive neurons and behavioral changes in a Parkinson’s disease mouse model.
National Cancer Institute Grants Support Study of Fluid Flow in Deadly Brain Tumors
[Virginia Tech News] Dr. Jennifer Munson, a cancer researcher at Virginia Tech's Fralin Biomedical Research Institute, has been awarded two new National Institutes of Health grants to advance greater understanding and improved treatment of a deadly brain cancer.
Modular Platform for Rapidly Investigating Long-Distance Propagation of Human Neural Network Activity
[Advanced Healthcare Materials] Scientists revealed that astrocytes significantly facilitate global activity within and across numerous rapidly merged organoids via combinatorial mechanisms.
KI Researchers Awarded Torsten SöDerberg Grants in Medicine
[Karolinska Institute] The Torsten Söderberg Foundation, in partnership with the Royal Swedish Academy of Sciences and the Swedish Medical Association, recognized two researchers from the Karolinska Institute to support their innovative research into brain health and infectious diseases.
LXR Agonist Rescues Synaptic Dysfunction and Degeneration in SPG3A Patient-Specific iPSC-Derived Neurons
[Acta Neuropathologica Communications] By comparing SPG3A patient iPSC-derived neurons with control cells using RNA-sequencing, researchers identified synaptic dysfunction as a top-altered pathway in addition to lipid-related pathways.
Extensive Restoration of Forelimb Function in Primates with Spinal Cord Injury by Neural Stem Cell Transplantation
[Nature Biotechnology] Scientists grafted clinically compatible spinal cord neural stem cells derived from hESCs.
DNA Replication Fork Speed Acts As a Pacer in Cortical Neurogenesis
[Nature Communications] Investigators demonstrated that selectively deleting mini-chromosome maintenance complex-binding protein in neural progenitor radial glial cells accelerates fork speed, triggering DNA damage, micronuclei formation, and widespread apoptosis, which ultimately activates p53 and causes microcephaly.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
