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Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
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Oxidized MIF Is an Alzheimer’s Disease Drug Target Relaying External Risk Factors to Tau Pathology
[Cell Reports Medicine] Researchers presented the discovery of a host protein-targeted antiviral drug highly active against HSV-1 in human brain organoids and human neuronal cell lines with a clear structure-activity relationship.
NAT10-Mediated N4-Acetylcytidine (Ac4c) Modification of PIK3R2 mRNA Promotes Malignant Progression of Glioblastoma
[Cell Death & Disease] Investigators found that NAT10 is highly expressed in glioblastoma and is positively correlated with malignant pathological features and poor prognosis in patients.
Immuno-Regulation of Brain Region-Specific Organoids Containing Isogenic Microglia-Like Cells
[Advanced Healthcare Materials] iPSC-derived microglia-like cells are co-cultured with isogenic forebrain cortical organoids, which were stimulated with extracellular vesicles of brain organoids differentiated from Alzheimer's disease patient-derived iPSCs.
Identification of Raptor and GLI1 As USP37 Substrates Highlight Its Context-Specific Function in Medulloblastoma Cells
[Oncogene] Scientists identifed Raptor and GLI1 as novel USP37 targets in sonic hedgehog-medulloblastoma and also suggest that ubiquitin specific protease 37 (USP37) may have context-specific oncogenic roles in addition to its previously described tumor suppressive function in these tumors.
Lesion-Remote Astrocytes Govern Microglia-Mediated White Matter Repair
[Nature] Using multiple transcriptional profiling methods, researchers investigated lesion-remote astrocytes from spared regions of mouse spinal cord following traumatic spinal cord injury.
Hypoglycemia Induces Brain Metabolic Reprogramming and Neurodegeneration via Serum Response Factor and Myocardin-Related Transcription Factor-A
[Signal Transduction and Targeted Therapy] Researchers investigated the molecular and cellular basis of hypoglycemia-induced brain damage using human neuron and glial cell cultures in vitro and hypoglycemic mouse models in vivo.
Quantitative Cell Type-Specific Immunopeptidome Analysis of Macrophage and Tumor Coevolution Reveals Therapeutic MHC-I Peptides in Glioblastoma
[Cancer Research] Investigators performed cell type–specific immunopeptidome analysis on primary macrophages and glioblastoma tumor cells in a coculture system to profile MHC-I–associated antigen presentation at the tumor–macrophage interface.
Astrocyte CCN1 Stabilizes Neural Circuits in the Adult Brain
[Nature] Combining a transcriptomic approach with ex vivo electrophysiology and in vivo imaging, researchers identified that astrocytes release CCN1 to maintain synapse and circuit stability in the adult visual cortex.
Hv1 Inhibition Rescues AD Pathology by Restoring Microglial Mitochondrial Function and Enhancing Mitochondrial Transfer
[Experimental & Molecular Medicine] Scientists observed that hydrogen voltage-gated channel 1 (Hv1) is upregulated in activated microglia in Alzheimer’s disease mouse models. Hv1 contributes to electron transport chain abnormalities, leading to mitochondrial oxidative stress, loss of mitochondrial membrane potential, impaired ATP production and deficient mitophagy in tau pathology.
NAT10-Mediated N4-Acetylcytidine (Ac4c) Modification of PIK3R2 mRNA Promotes Malignant Progression of Glioblastoma
[Cell Death & Disease] Investigators found that NAT10 is highly expressed in glioblastoma and is positively correlated with malignant pathological features and poor prognosis in patients.
Phosphorylated Tau Exhibits Antimicrobial Activity Capable of Neutralizing Herpes Simplex Virus 1 Infectivity in Human Neurons
[Nature Neuroscience] Researchers showed that tau is hyperphosphorylated in neurons in response to viral infection and can neutralize herpes simplex virus 1 infectivity by directly binding to viral capsids.
Tiziana Life Sciences Doses First Patient in Phase II Alzheimer’s Clinical Trial
[Tiziana Life Sciences, Ltd. (GlobeNewswire)] Tiziana Life Sciences, Ltd. announced that the first patient has been dosed with intranasal foralumab in its Phase II randomized, placebo-controlled clinical trial in patients with early Alzheimer’s disease.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
