Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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LXR Agonist Rescues Synaptic Dysfunction and Degeneration in SPG3A Patient-Specific iPSC-Derived Neurons

November 19, 2025

[Acta Neuropathologica Communications] By comparing SPG3A patient iPSC-derived neurons with control cells using RNA-sequencing, researchers identified synaptic dysfunction as a top-altered pathway in addition to lipid-related pathways.

Extensive Restoration of Forelimb Function in Primates with Spinal Cord Injury by Neural Stem Cell Transplantation

November 19, 2025

[Nature Biotechnology] Scientists grafted clinically compatible spinal cord neural stem cells derived from hESCs.

DNA Replication Fork Speed Acts As a Pacer in Cortical Neurogenesis

November 19, 2025

[Nature Communications] Investigators demonstrated that selectively deleting mini-chromosome maintenance complex-binding protein in neural progenitor radial glial cells accelerates fork speed, triggering DNA damage, micronuclei formation, and widespread apoptosis, which ultimately activates p53 and causes microcephaly.

Spinal Cord Tau Pathology Induces Tactile Deficits and Cognitive Impairment in Alzheimer’S Disease via Dysregulation of CCK Neurons

November 19, 2025

[Nature Neuroscience] Gain- and loss-of-function studies demonstrate that Tau pathology in spinal cord cholecystokinin (CCK) neurons contributes to tactile dysfunction and cognitive function.

National Cancer Institute Grants Support Efforts to Understand How Fluid Flow Drives Deadly Brain Cancer

November 19, 2025

[Virginia Tech (EurekAlert)] Dr. Jennifer Munson, a cancer researcher at Virginia Tech's Fralin Biomedical Research Institute at VTC, has been awarded two new National Institutes of Health grants to advance greater understanding and improved treatment of a deadly brain cancer.

Distinct Transcriptomic and Epigenomic Responses of Mature Oligodendrocytes during Disease Progression in a Mouse Model of Multiple Sclerosis

November 18, 2025

[Nature Neuroscience] Scientists used single-cell multiome assay for transposase-accessible chromatin and RNA sequencing targeting oligodendroglia (OLG) from the experimental autoimmune encephalomyelitis multiple sclerosis mouse model at multiple disease stages.

In Situ Structural Mechanism of Epothilone-B-Induced CNS Axon Regeneration

November 14, 2025

[Nature] To address the intracellular response to injury, scientists developed an in situ cryo-electron tomography and cryo-electron microscopy platform to mimic axonal damage and present the structural mechanism underlying thalamic axon regeneration induced by the drug epothilone B.

CASKIN2 Mediates PTPσ-Orchestrated Transsynaptic Mechanisms at Excitatory Synapses

November 14, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Investigators delineated the pivotal role of CASKIN2 in modulating diverse postsynaptic properties and establish a molecular mechanism governing its function.

Lymphoid Gene Expression Supports Neuroprotective Microglia Function

November 5, 2025

[Nature] Scientists showed that the protective function of microglia is governed by the transcription factor PU.1, which becomes downregulated following microglial contact with plaques.

Transcriptomic and Spatial Organization of Telencephalic GABAergic Neurons

November 5, 2025

[Nature] Researchers conducted a systematic and in-depth analysis of the transcriptomic and spatial organization of GABAergic neuronal types in all regions of the mouse telencephalon and their developmental origins.

Predicted Molecules Followed by Experimental Validation for Protecting Human Neurons from Oxidative Stress-Induced Cytotoxicity

November 5, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Investigators carried out in silico screening of ~6 million molecules to discover Z124 that is nearly as effective as carboxypeptidase E.

Radial Astroglia Cooperate with Microglia to Clear Neuronal Cell Bodies during Zebrafish Optic Tectum Development

November 5, 2025

[Cell Reports] During zebrafish optic tectum development, researchers observed radial astroglia forming dynamic, spherical projections from their basal processes.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.