Neural Cell News

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.

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Lymphoid Gene Expression Supports Neuroprotective Microglia Function

November 5, 2025

[Nature] Scientists showed that the protective function of microglia is governed by the transcription factor PU.1, which becomes downregulated following microglial contact with plaques.

Transcriptomic and Spatial Organization of Telencephalic GABAergic Neurons

November 5, 2025

[Nature] Researchers conducted a systematic and in-depth analysis of the transcriptomic and spatial organization of GABAergic neuronal types in all regions of the mouse telencephalon and their developmental origins.

Predicted Molecules Followed by Experimental Validation for Protecting Human Neurons from Oxidative Stress-Induced Cytotoxicity

November 5, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Investigators carried out in silico screening of ~6 million molecules to discover Z124 that is nearly as effective as carboxypeptidase E.

Radial Astroglia Cooperate with Microglia to Clear Neuronal Cell Bodies during Zebrafish Optic Tectum Development

November 5, 2025

[Cell Reports] During zebrafish optic tectum development, researchers observed radial astroglia forming dynamic, spherical projections from their basal processes.

Stra8 Links Neuronal Activity to Inhibitory Circuit Protection in the Adult Mouse Brain

November 5, 2025

[Cell Reports] The authors showed that activity-induced expression of stimulated by retinoic acid gene 8 (Stra8) protects neurons from degeneration.

Preclinical Evaluation of the Efficacy of the Cyclin-Dependent Kinase Inhibitor Ribociclib in Combination with Letrozole against Patient-Derived Glioblastoma Cells

November 5, 2025

[Molecular Cancer Therapeutics] In a phase 0/I trial in patients with recurrent glioblastoma (GBM), investigators observed that letrozole permeates into the GBM tissue and triggers dose-dependent changes in the expression of genes regulating the cell cycle.

The New Frontier in Understanding Human and Mammalian Brain Development

November 5, 2025

[Nature] The authors highlight recent studies that have identified novel developmental cell populations and revealed conserved and divergent patterns of cell genesis, migration, and maturation across species.

Sheena Josselyn Honored with Peter Seeburg Integrative Neuroscience Prize

November 5, 2025

[University of Toronto] Sheena Josselyn has been named the recipient of the 2025 Peter Seeburg Integrative Neuroscience Prize. The $100,000 USD prize honours scientists who successfully connect molecular and cellular events to brain circuits and systems to explain cognitive and behavioral processes.

Scripps Research Awarded $4 Million to Advance Platform for Neurodevelopmental Disorders

October 29, 2025

[Scripps Research] Scripps Research associate professor Giordano Lippi has been awarded a $4 million grant from the California Institute for Regenerative Medicine (CIRM) to develop a novel platform that could restore healthy gene function in neurodevelopmental disorders caused by haploinsufficiency.

Changes in Neural Progenitor Lineage Composition during Astrocytic Differentiation of Human iPSCs

October 29, 2025

[elife] Investigators identified transcriptomic differences at the single-cell level, between astrocytes generated from LMX1A reporter positive or negative cells, as well as non-patterned astrocytes and neurons.

Restoration of sFRP3 Preserves the Neural Stem Cell Pool and Spatial Discrimination Ability in a Mouse Model of Alzheimer’s Disease

October 29, 2025

[Journal of Neuroscience] Using mice of both sexes, researchers performed RNA-sequencing on the hippocampal dentate gyrus and identified differentially-expressed regulators of neurogenesis in the Wnt signaling pathway that regulates many aspects of cell proliferation.

Targeting STAU1 Prevents P53 Apoptotic Signaling in Neurodegeneration

October 28, 2025

[Cell Death & Disease] Scientists showed by combined transcriptomic and functional analyses that STAUFEN-1 (STAU1) reduction results in the inhibition of apoptosis through the p53 pathway.

Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.