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Identification and Validation of the Protective Gene BCAT2 Related to Amino Acid Metabolism in Idiopathic Pulmonary Fibrosis
[Clinical and Experimental Medicine] Experimental validation researchers confirmed the significantly downregulation of BCAT2 in the lung tissues of IPF patients and in TGF-β1-treated alveolar epithelial cells
Cold Inducible RNA Binding Protein Promotes Fibroblast Activation and Its Inhibition Represents a Potential Therapeutic Target in Pulmonary Fibrosis
[Scientific Reports] Scientists investigated cold-inducible RNA-binding protein's function using an in vivo bleomycin-induced pulmonary fibrosis mouse model via intratracheal administration and an in vitro model with primary lung fibroblasts.
Pulmonary Fibroblasts Activated by the Addition of TNF-α and IL-4 Enhance Lymphangiogenic Capacity and Ameliorate Lung Fibrosis in an Allogeneic Rat Model
[PloS One] Researchers investigated whether human and rat pulmonary fibroblasts, when stimulated with TNF-α and IL-4, acquire lymphangiogenic and antifibrotic properties.
P53 Drives Lung Cancer Regression through a TSC2/TFEB-Dependent Senescence Program
[Cancer Discovery] Investigators used mouse and human models to deconstruct the transcriptional programs and sequelae underlying robust therapeutic responses in lung adenocarcinoma.
A Recombinant Targeted Bionanoparticle In Vitro Expressing a Gene-Editing Protein for Epidermal Growth Factor Receptor Mutant Lung Cancer
[ACS Nano] Scientists reported a recombinant targeted bionanoparticle that in vitro expresses Cas9 protein, tBioNP vitro-Cas9, for gene editing of epidermal growth factor receptor mutant lung cancer.
An H4K12la/CEBPB-AKR1C2 Signaling Axis Modulates the mTOR Pathway to Regulate Cisplatin Resistance in Lung Cancer
[Oncogene] Researchers demonstrated that histone lactylation is closely associated with cisplatin resistance and correlates with poor prognosis of NSCLC.
YTHDC2 Inhibits the Resistance of Lung Cancer to EGFR-TKI through Cuproptosis
[Oncogene] Scientists demonstrated that YTHDC2 expression is significantly downregulated in osimertinib-resistant patient-derived xenograft tissues and lung cancer cell lines compared to their osimertinib-sensitive counterparts.
Exploring the Effects of Tinzaparin and Cisplatin on Lung Cancer Cells In Vitro
[Cancer Cell International] The authors assessed the cell viability, proliferation, colony formation, and intracellular lipid droplet accumulation of Nine NSCLC cell line treated with tinzaparin, cisplatin, or a combination.
PRKD1/EIF5A/β-Catenin Axis Inhibits Tumorigenesis and Metastasis in Non-Small-Cell Lung Cancer
[Clinical and Experimental Medicine] Investigators reported that PRKD1 negatively regulates β-catenin protein abundance. PRKD1 promoted ubiquitination and degradation of EIF5A.
RNA Sequencing Reveals Differential Expression of Circular RNAs in Human Small Cell Lung Cancer
[Scientific Reports] Researchers performed RNA sequencing to identify differentially expressed circRNAs in small cell lung cancer compared with normal lung tissue.
Interleukin-7 Induces EMT to Promote Tumor Growth and Metastasis in NSCLC via Notch1/TGF-β Pathway
[Scientific Reports] 119 cases of NSCLC tissue specimens were used to determine the expression levels and prognostic values of IL-7, IL-7R, E-cadherin and Vimentin.
Molecular Mechanism of METTL7B-Mediated M6a Modification in Ferroptosis of Non-Small Cell Lung Cancer Cells
[Free Radical Research] Scientists investigated the mechanism of METTL7B-medaited m6A modification in NSCLC cell ferroptosis. NSCLC cells, SK-MES-1/PC9/H1975/A549, and normal cells, BEAS-2B, were cultured.
