Newsletters

[Nature Communications] Scientists identified a distinct subset of MSCs expressing integrin α8 within the bone marrow endosteum. These cells exhibited distinct MSC properties and higher hematopoietic supportive activity than other MSC subsets.

[Acta Pharmacologica Sinica] Using mechanical and electrical stimulation as controls, scientists examined optically stimulated MSCs and T cells and their conditioned medium in breast cancer and osteoclast models.

[Stem Cell Reviews and Reports] By integrating insights from T1D immunopathogenesis, MSC biology, genome editing, and translational immunology, the authors propose a framework linking immune engineering with controlled differentiation, functional maturation, and long-term safety evaluation.

[Acta Biomaterialia] Scientists described a granular biomaterial approach to create a multicellular platform for hematopoietic stem cell (HSC) culture. By seeding HSCs amongst MSC-laden hydrogel microspheres, they established paracrine-mediated interactions between HSCs and hydrogel encapsulated MSCs.

[Acta Biomaterialia] Researchers developed an integrated microcarrier system via digital light processing, which encapsulates MSCs within microgels functionalized with cardiac-derived decellularized ECM particles.

[FASEB Journal] Scientists summarize current evidence from animal models and clinical studies on the application of MSCs and MSC-derived exosomes in treating Intrauterine adhesions and endometriosis.

[Life Sciences] Researchers investigated the protective effect and underlying mechanism of the Schlafen (SLFN) 11 gene against human MSC senescence in vitro.

[Autophagy] Researchers demonstrated that 24-h exposure to 1% oxygen significantly enhanced HIF1A/HIF-1α expression in dental pulp stem cells.

[BMC Medicine] The authors found that under low-dose conditions, only iMSCs with IL-2 overexpression—but not unmodified iPSC-derived MSCs or free IL-2 alone—induced robust upregulation of CD25 on CD8+ T cells.

[Blood] Investigators identified fibroblast‑derived fibroblast growth factor 18 (FGF18) as a novel stromal cytokine that reprograms leukemia-immune interactions.

[Blood] Researchers identified JUND as a driver of resistance to menin–MLL inhibitors in MLL-rearranged leukemia, revealing a promising combination strategy to improve therapeutic responses.

[Leukemia] Scientists showed that local oxygen levels regulate hematopoietic stem cell growth and potency, identifying oxygen-sensing pathways and PRSS2 as potential targets to improve blood stem cell therapies.