Newsletters

[Journal of the American Chemical Society] Researchers developed an inhalable enzyme-activated polymeric proteolysis-targeting chimera (PROTAC) nanococktail that enables concurrent degradation of two key profibrotic signaling regulators in fibrotic lungs.

[EMBO Reports] By using mouse stem cell lines, scRNA-seq, and transcriptomic and chromatin accessibility profiling, scientists showed that Foxe1 knockout impairs Nkx2-1+ cell differentiation and maturation into thyroid follicular-like cells.

[Cancer Discovery] Investigators discovered that breast cancer–derived lung metastases stimulate the proliferation of alveolar type II (AT2) cells in their vicinity and reprogram them into lipid feeder cells in mice and patients using spatial analysis.

[Cell Death Discovery] The authors demonstrated that the transcription factor KLF15 governs cisplatin sensitivity by orchestrating mitochondrial biogenesis and redox homeostasis.

[Cancer Cell International] Researchers identified TMEM33 as a driver of lung adenocarcinoma progression, promoting tumor growth and migration through activation of the PI3K/AKT/mTOR signaling pathway.

[Scientific Reports] Investigators showed that acquired resistance to first-line osimertinib in EGFR-mutant lung cancer arises through diverse mechanisms, underscoring the need for molecular profiling to guide subsequent therapy.

[Expert Review of Molecular Diagnostics] Scientists highlight extracellular vesicles as promising liquid biopsy biomarkers for non-small cell lung cancer, with potential to improve early diagnosis, prognosis, and personalized treatment monitoring.

[Nature Communications] Utilizing single cell RNA-sequencing of human pulmonary fibrotic lungs and mouse genetic models, researchers identified a unique cluster of fibrosis-associated pericytes which was not present in normal lungs and exhibited a distinctive transcriptional signature indicating transition of normal pericytes to a fibrotic state.

[Biomaterials Research] Researchers engineered a hybrid human umbilical cord mesenchymal-stem-cell-derived decellularized matrix (CDM)@Fibrin/poly(ε-caprolactone) (PCL) scaffold by incorporating CDM into a 3D-printed PCL framework.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators identified cells contributing to subretinal fibrosis by using Col1a1-YFP reporter mice to noninvasively image collagen production in real-time in vivo in two disease models, a resolving retinal injury model and a fibrotic model of subretinal disease.

[Communications Biology] To determine how vimentin facilitates cell migration through the ECM and around neighboring cells in tissues, researchers examined the collective invasion of cell spheroids embedded in collagen networks.

[FASEB Journal] Scientists investigated the role and underlying mechanism of circTMEM230 in the degeneration of endplate chondrocytes.