The Dichotomous Roles of Microbial-Modified Bile Acids 7-Oxo-DCA and isoDCA in Intestinal Tumorigenesis

Researchers found that although high-fat diet treatment in mice elevated both 7-oxo-deoxycholic acid (7-oxo-DCA) and isoDCA levels, during intestinal tumorigenesis, 7-oxo-DCA levels increased while isoDCA levels decreased.