Newsletters

[Cell Stem Cell] Investigators presented an approach that involves differentiating universal major histocompatibility complex (MHC)-deficient hiPSCs into CCR7⁺ migratory dendritic cells.

[Lab on a Chip] The authors presented a novel microphysiological system using a compartmentalized microfluidic device to integrate co-cultured hiPSC-derived cardiomyocytes and sympathetic neurons.

[Stem Cell Reports] The therapeutic potential of autologous-derived dendritic cells is challenged by the number and quality produced and the diversity of antigens presented. Researchers addressed this limitation by developing a protocol to generate induced pruriceptors from hiPSCs.

[Stem Cell Reports] Scientists employed CRISPR/Cas9-based functional screening coupled with single-cell RNA-seq to investigate the epigenetic regulation governing the pluripotency network in mESCs.

[Communications Biology] Researchers developed a strategy to establish human tetraploid iPSC (4N-iPSC) through cell fusion and found that iPSC-derived cardiomyocytes (iPS-CMs) derived from 4N-iPSCs were phenotypically similar to post-mitotic cardiomyocytes and were distinct from conventional iPS-CMs.

[Human Genetics] Investigators described an optimized CRISPR-based strategy for correcting a heterozygous HNF1A frameshift mutation in HNF1A-MODY patient-derived hiPSCs.

[Chinese Medical Journal] Scientists summarize the recent advancements and molecular mechanisms of stem cells (SCs) in the treatment of diabetes mellitus (DM), underscoring the feasibility, benefits, and current limitations of SC therapy for DM, and offering a lucid perspective on their therapeutic possibilities.

[Breakthrough T1D] Greenstone Biosciences has been awarded a Breakthrough T1D Industry Discovery and Development Partnership (IDDP) grant to develop a T1D-derived islet cell platform aimed at understanding and protecting insulin-producing β cells in people with type 1 diabetes (T1D).

[Nature] Researchers metagenomically sequenced 4,526 longitudinal fecal samples from 714 mother–infant pairs. They observed that the maternal gut microbiome undergoes only subtle changes during pregnancy and postpartum, influenced by diet, infections, and pre-pregnancy smoking.

[Nature] Scientists developed an in vivo model that efficiently recovers human T cells from solid tumours, permitting genome-wide CRISPR screens with few mice. Tumor-infiltrating T cells from this model exhibit hallmarks of dysfunction compared with splenic T cells, creating an ideal screening context.

[EMBO Molecular Medicine] Scientists defined a new role for PRMT5 in regulating and coordinating the interplay between the innate and adaptive immune response.

[Cell Reports] The authors performed single-cell RNA sequencing on 26 blood samples from 18 neonates, spanning acute sepsis, convalescence, and healthy controls. They identified 57 cell subtypes, revealing acute lymphoid depletion and myeloid expansion.