Newsletters

[NPCF (PR Newswire)] The National Pediatric Cancer Foundation (NPCF) has awarded a $1 million research grant to Dr. JinSeok Park to support mechanistic and translational research targeting metastatic fusion‑positive rhabdomyosarcoma, a rare, clinically aggressive pediatric sarcoma characterized by the PAX3‑FOXO1 fusion oncoprotein.

[FUJIFILM Biosciences] FUJIFILM Biosciences and NextCell Pharma AB announced a global launch resulting from their collaboration. The offering consists of FUJIFILM Biosciences' PRIME-XV MSC Expansion XSFM medium and NextCell-Cord RUO, a research-use-only (RUO) MSC product derived from umbilical cord tissue.

[Blood] Scientists identified a subset of Procr+ endothelial cells (ECs) with progenitor-like properties in bone marrow. Procr binds HSPA8 to promote Foxc2 nuclear translocation, upregulating Dll4 transcription to sustain Dll4/Notch3 activation in MSCs, revealing a Procr/HSPA8/Foxc2/Dll4 axis essential for EC and MSC crosstalk.

[Cell Death & Disease] The authors summarize the latest evidence regarding the temporal therapeutic role of MSCs via the “immune-mitochondrial” axis at different stages of cerebral ischemia-reperfusion injury. They elucidate the role of mitochondria as a central hub connecting metabolic crisis and immune storm.

[Stem Cells] Scientists highlight the diverse therapeutic roles of MSCs and their derivatives, such as exosomes and engineered vectors, in brain tumor management.

[Stem Cell Reviews and Reports] Investigators synthesize emerging evidence on MSC priming for tendon regeneration, assess its histological and biomechanical foundations, and elucidate its translational potential for achieving biologically integrated and clinically durable rotator cuff repair.

[Stem Cell Research & Therapy] The authors evaluate the therapeutic efficacy and potential mechanisms of bone marrow-derived MSCs, adipose-derived stromal cells, umbilical cord-derived MSCs, synovium-derived MSCs, ESC-derived MSCs and iPSC-derived MSCs in modulating the joint microenvironment.

[Brain] This Phase I/IIa study analyzed safety and treatment effect of three intravenous infusions of autologous adipose-derived MSCs in 24 chronic traumatic brain injury patients.

[Clinical and Experimental Medicine] Researchers demonstrated that circ-ABCA1 promotes breast cancer stem cell-mediated malignant progression by modulating miR-33a-5p/EIF4A3 axis.

[Advanced Science] Researchers uncovered the mechanosensor PIEZO1 as a key factor in promoting AML progression and maintaining LSC stemness by HIF1A-SLC7A11 axis-mediated ferroptosis defense.

[Cell Stem Cell] Investigators showed that leukemic stem cells in acute myeloid leukemia exhibit elevated ketogenesis, driven by fatty acid oxidation, to produce β-hydroxybutyrate.

[Cell Stem Cell] By molecular and functional profiling of leukemic stem cells (LSC) from >150 patients, researchers identified four LSC subtypes. These mirror distinct hematopoietic lineage stages, which determine the expression ratio between the venetoclax target BCL-2 and resistance-inducing proteins MCL-1 and BCL-xL.