Prostaglandin D2 Axis Impairs Immunity against Melanoma via Dendritic Cells and γδ T Cells in Middle-Aged Mice

Researchers showed that the absence of PLA₂G2D or the PGD₂ receptor, PTGDR, restricts primary tumor growth and lung metastasis of subcutaneously implanted melanoma, as demonstrated using middle-aged Pla2g2d−/− and Ptgdr^−/− mice.