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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
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Human Subcutaneous Derived Stromal Vascular Fraction Endothelial Cells Display Venous and Arterial Markers in Culture and 3D Capillaries
[Tissue Engineering and Regenerative Medicine] Researchers investigated endothelial cells from the stromal vascular fraction of human subcutaneous white adipose tissue in 2D culture and 3D bioengineered skin models to better define their specific subtypes.
Ethanol Alters DNMT1/3a/3b Expression Profile, Promotes Persistent DNA Hypomethylation in Human Brain Endothelial Cells, and Impairs Late Cortical Angiogenesis
[Journal of Neurochemistry] Scientists investigated whether ethanol-induced effects on endothelial cells involve epigenetic reprogramming, specifically through alterations in DNA methylation profiles.
Endothelial IRE1 Signaling Maintains Blood-Brain Barrier Integrity and Limits Neuroinflammation after Traumatic Brain Injury
[Cell Death & Disease] The authors investigated the role of endothelial IRE1 signaling in traumatic brain injury using endothelial cell-specific IRE1 conditional knockout mice subjected to cortical ablation.
Endothelial TRIM47 Regulates Blood-Brain Barrier Integrity and Cognition via the KEAP1/NRF2 Signaling Pathway in Mice
[Communications Biology] Investigators devised a multilayered experimental plan to decipher the biological mechanisms underlying TRIM47’s role in cerebral small vessel disease pathophysiology.
GlycoRNA Complexed with Heparan Sulfate Regulates VEGF-A Signaling
[Nature] Researchers uncovered a previously unrecognized regulatory axis by which cell surface ribonucleoproteins negatively modulate heparan sulfate-mediated signalling in the context of angiogenesis driven by VEGF-A.
Sine Oculis Homeobox 1 Drives Endothelial Dysfunction in Preclinical Pulmonary Arterial Hypertension
[Science Translational Medicine] Investigators found that the developmental transcription factor sine oculis homeobox 1 (Six1) was increased in patients with pulmonary hypertension (PH) and that deleting Six1 in endothelial cells improved pathology in a mouse model of PH.
Endothelial PDLIM5 Promotes Tip Cell Filopodia Formation and Tumor Angiogenesis by Regulating ACTN1/ACTN4-Dependent Actin Bundling
[Nature Communications] Scientists demonstrated that tumor endothelial cells (TECs) highly express actin-binding genes, with PDZ and LIM domain 5 (PDLIM5), a cytoskeletal protein, significantly upregulated in TECs and correlated with poor patient survival.
Bmp9 Regulates Notch Signaling and the Temporal Dynamics of Angiogenesis via Lunatic Fringe
[Developmental Cell] Through predictive computational modeling validated in mice, zebrafish, and human cell lines, researchers uncovered that Bmp9 enhances Notch activity synergistically by upregulating Lunatic Fringe in endothelial cells.
p16-Mediated G0/G1 Cell Cycle Arrest Leads to SASP and Fibrosis in Fuchs Endothelial Corneal Dystrophy
[Cell Death & Disease] Scientists investigated the impact of chronic exposure to combined ultra-violet light and the oxidized estrogen metabolite 4-hydroxyestradiol on healthy corneal endothelial cells.
Apoptotic Vesicles from Endothelial Cells Promote Endothelial Progenitor Cell Differentiation and Angiogenesis via Mir-30a-5p Mediated Activation of the EGFR/PI3K/AKT/VEGF Pathway
[Stem Cell Research & Therapy] Investigators explored whether endothelial cell (EC)-derived apoptotic extracellular vesicles can promote the differentiation of endothelial progenitor cells into ECs, facilitating wound angiogenesis, and to deeply analyze the underlying molecular mechanisms and key signaling pathways.
LncRNA UNC5C-AS1 Inhibits Angiogenesis and Induces Endothelial Apoptosis via the Mir-148a-3p/EMP1 Axis in Preeclampsia
[Cell Adhesion & Migration] The authors investigated the effect of UNC5C-AS1 on HUVEC function in preeclampsia (PE). UNC5C-AS1 was downregulated in PE placentas.
Targeting Lymphatic Vessels Enhances Bone Regeneration by Augmenting Osteoclast Activity in Mouse Models of Amputation
[Journal of Clinical Investigation] Using a lymphatic system–specific reporter line, investigators discovered that lymphatic vessels grow toward the nail region from the ventral side of the digit during quiescence and after amputation.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
