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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Zinc Accumulation-Induced Integrated Stress Response Triggers β-Cell Identity Loss
[Cell Research] Using a model of human embryonic stem cell-derived islets (SC-islets), scientists reveal that accumulated zinc triggers the integrated stress response, with elevated ATF4 expression in SC-β cells.
PTPN2 Deficiency Amplifies Inflammatory Signalling and Impairs Functional Maturation of Human Stem Cell-Derived Islets
[Stem Cell Research & Therapy] PTPN2 expression in β cells from type 1 diabetes organ donors and during the differentiation of human stem cell-derived islets was evaluated using single-cell RNA-sequencing datasets.
IL-18 Promotes Pancreatic Fibrosis via Release of IL-4 from Pancreatic Stellate Cells and Induces Macrophage M2 Polarization
[Scientific Reports] Human chronic pancreatitis (CP) tissues and caerulein-induced CP models in mice were used to explore the role of IL-18 in fibrosis.
An Oncogenic KRAS-Driven Secretome Involving TNFα Promotes Niche Preparation Prior to Pancreatic Cancer Onset
[Molecular Cancer] Investigators acquired time-resolved, single-cell transcriptomic, and accessible-chromatin data from human pluripotent stem cell-derived pancreatic duct-like organoids inducibly expressing KRASG12D and from various niche cells.
Convergence for Inactivation of TGF-β Signaling Is a Common Feature of Advanced Pancreatic Cancer
[Cancer Discovery] Researchers provided a high-level profile of the genetic features distinguishing locally advanced from metastatic PDAC, potentially serving as a biomarker of borderline resectable or locally advanced PDACs most likely to benefit from neoadjuvant chemoradiation.
MTFP1 Drives Pancreatic Cancer Liver Metastatic Colonisation by Regulating Mitochondrial Metabolism Reprogramming
[Gut] Scientists identified key drivers that reprogram PDAC mitochondrial function and its role in remodeling the immunosuppressive tumour microenvironment during PDAC liver colonization.
Gastrointestinal Bleeding in Severe Acute Pancreatitis: Pathogenesis and Clinical Management
[Digestive Diseases and Sciences] The authors systematically synthesize current evidence on the pathogenesis of severe acute pancreatitis-associated gastrointestinal bleeding, thereby informing the development of targeted intervention strategies, improving the precision of individualized therapeutic decision-making, and ultimately providing a robust theoretical basis to optimize patient outcomes.
Can-Fite: Patient with Decompensated Liver Cirrhosis Successfully Undergoes Liver Transplantation Following Treatment with Namodenoson
[Can-Fite BioPharma, Ltd.] Can-Fite BioPharma, Ltd. announced that a patient with advanced decompensated liver cirrhosis who was treated with Namodenoson subsequently underwent a successful liver transplantation.
NAC and DNase I Synergistically Reduce NETs to Attenuate Severe Acute Pancreatitis via Suppressing the NETs/NF-κB/CXCL3 Pathway
[Apoptosis] Researchers investigated whether combined N-acetylcysteine (NAC) and deoxyribonuclease I (DNase I) therapy mitigates severe acute pancreatitis and associated lung injury by suppressing neutrophil extracellular traps (NETs) formation and degradation, respectively, and explores the underlying molecular mechanisms.
Evaluation of Rat Pancreatic Islets Damage after siRNA Microporation
[PLOS One] The authors evaluated whether microporation is a suitable technique for the transfection of pancreatic islets and whether the selected siRNA is recognized by islet cells as foreign, potentially triggering an inflammatory or cytotoxic response.
Glycolytic Heterogeneity Drives Metabolic-Targeted Therapy in Pancreatic Ductal Adenocarcinoma
[Signal transduction and targeted therapy] Scientists investigated whether glycolytic activity follows a consistent expression pattern across pancreatic ductal adenocarcinoma patients and explored how metabolic diversity influences therapeutic responses.
Wilms Tumor 1-Expressing Stromal Cells Promote Pancreatic Cancer Progression
[Cancer Research] The authors investigated the contribution of WT1+ mesenchymal cells to cancer-associated fibroblasts populations and evaluated the functional role of WT1+ stromal cells in pancreatic cancer.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
