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Pancreatic Cell News
Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human
[Advanced Science] Investigators established CD168 as a marker for proliferating islet cells, providing a tool to study β-cell proliferation and novel insights into islet cell proliferation and maturation mechanisms.
Restoration of PKM1 Improves Functional Maturation of Human Stem-Cell Derived-β Cell by Regulating PEP Metabolism
[Nature Communications] Researchers revealed a critical role of PKM1-regulated PEP metabolism in stem cell-derived-β cell functional maturation.
ULK1 Knockout Suppresses Pancreatic Cancer Progression by Inhibiting Autophagy and Enhancing Antitumor Immunity
[Experimental & Molecular Medicine] Researchers investigated the role of unc-51-like kinase 1 (ULK1) using tissue-specific deletion in genetically engineered mouse models.
Comparative β-Cell Development: Insights from Rodents, Humans, and Induced Pluripotent Stem Cell Models
[Stem Cell Research & Therapy] Stepwise pancreatic β-cell differentiation protocols, designed to recapitulate key developmental milestones of pancreatic organogenesis—from definitive endoderm to mature, glucose-responsive β-cells—draw on insights from both rodent and human developmental biology.
Mitochondrial Position Responds to Glucose Stimulation in a Model of the Pancreatic Beta Cell
[Biophysical Journal] Researchers examined the spatial organization of mitochondria within MIN6 pancreatic beta cells under variable glucose conditions.
Deprivation of EGFR Signal Causes Senolysis in PDAC with CDK4/6 Inhibition
[Cell Death & Differentiation] Scientists proposed that the CDK4/6 inhibitor may achieve greater therapeutic efficacy when combined with the EGFR inhibitor than KRAS inhibitor monotherapy.
Controlled Self-Immolative Release of β-Lapachone via an Optimized -Hydroxybenzyl Linker for Targeted Pancreatic Cancer Therapy
[Journal of the American Chemical Society] Researchers explored the development of an optimized β-lapachone small molecule prodrug platform that utilizes a β-glucuronide-protected para-hydroxybenzyl moiety alkylated to one of β-lapachone’s carbonyls via an indium-mediated Barbier-type reaction.
C-Rel Drives Pancreatic Cancer Metastasis through Fibronectin-Integrin Signaling-Induced Isolation Stress Resistance and EMT
[Molecular Cancer] Scientists identified c-Rel as an oncogenic driver in PDAC that promotes EMP, extracellular matrix remodeling, and survival under isolation stress.
αPD-1-Conjugated Acid-Cleavable Nanodrugs Overcomes Cellular Immunotherapy Barriers in Pancreatic Tumors
[Nature Communications] Scientists presented a nanoengineered tumor-infiltrating lymphocyte therapy using anti-PD-1 antibody-conjugated ZIF-8 nanoparticles to effectively suppress pancreatic tumor growth.
Microbubble-Enhanced Ultrasound Stimulation of β-Cells Improves Insulin Release and Glycemic Control in Mice
[Journal of Nanobiotechnology] The authors presented an ultrasound-mediated approach to enhance insulin release by selectively stimulating pancreatic β-cells via targeted microbubbles.
CUL2 Confers Ferroptosis Resistance in Pancreatic Cancer by Disrupting KEAP1-Mediated NRF2 Degradation
[Cancer Cell International] Scientists revealed a novel mechanism whereby CUL2 promotes pancratic cancer progression and ferroptosis resistance through regulation of the KEAP1-NRF2 axis.
Transgelin Defines Pro-Tumorigenic Cancer-Associated Fibroblasts in Pancreatic Cancer
[British Journal of Cancer] Scientists performed a single-cell assay for transposase-accessible chromatin with high-throughput sequencing and single-cell RNA sequencing on pancreas tissues from KPC mice characterise myofibroblastic cancer-associated fibroblast heterogeneity.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
