Pancreatic Cell News
Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Serine/Threonine/Tyrosine Kinase 1 Drives Pancreatic Carcinogenesis via GSK3β Sequestration-Mediated Wnt/β-catenin Pathway Hyperactivation
[Signal Transduction and Targeted Therapy] Investigators demonstrated that serine/threonine/tyrosine kinase 1 (STYK1) directly binds to β-catenin and GSK3β, inhibiting GSK3β activity by increasing the level of its kinase-inactive form, which is phosphorylated at S9, and promoting its sequestration into multivesicular bodies.
Self-Amplifying NRF2-EZH2 Epigenetic Loop Converts KRAS-Initiated Progenitors to Invasive Pancreatic Cancer
[Nature Cancer] To examine the role of oxidative stress, a putative PDAC risk factor, investigators established an organoid-based transformation system.
Cingulin Is an RNA-Binding Protein Promoting Pancreatic Cancer through Enhancing Importin 7-Mediated Phospho-ERK Nuclear Translocation
[Cell Reports] Researchers demonstrated the critical oncogenic role of cingulin in PDAC pathogenesis.
Pancreatic Islet β-cell Subtypes Are Derived from Biochemically-Distinct and Nutritionally-Regulated Islet Progenitors
[Nature Communications] The authors showed that islet progenitors with distinct gene expression and DNA methylation patterns produce β-cell subtypes of different secretory function, proliferation rate, and viability in male and female mice.
Evaluation of Transduction Efficiency in Pancreatic Beta and Alpha Cells Utilizing Various AAV Serotypes
[Scientific Reports] Investigators determined whether alternative serotypes, specifically adeno-associated viruses (AAV) 2, AAV6, and AAV9, commonly used for gene transfer, can efficiently transduce pancreatic cells in vitro.
Histone Serotonylation Promotes Pancreatic Cancer Development via Lipid Metabolism Remodeling
[Nature Communications] Researchers observed the higher levels of histone serotonylation and transglutaminases 2 in both PDAC tissues and cell lines in comparison with their normal counterparts, and inhibition of histone serotonylation suppresses PDAC development.
Unraveling the Sweet Connection between Pancreatic Cancer and Hyperglycemia
[Trends In Endocrinology and Metabolism] The authors examine the complex pathophysiology of PDAC-induced hyperglycemia, focusing on impaired insulin sensitivity, β cell dysfunction, chronic inflammation, and alterations in the gut microbiome and circadian rhythm.
Stem Cell Therapies for Diabetes
[Nature Medicine] Investigators critically review the scientific advances, the clinical trials, and the various regulatory considerations that will need to be overcome for human stem cell-derived pancreatic islet-like cells to become the next cell therapy breakthrough for diabetes treatment.
ZMYND8 Promotes the Warburg Effect and Tumorigenesis through C-Myc Activation in Pancreatic Cancer
[Oncogene] The authors employed an epigenetic siRNA library to identify a crucial regulator, ZMYND8, which is involved in glycolysis in pancreatic cancer cells.
ChemPerturb-Seq Screen Identifies a Small Molecule Cocktail Enhancing Human Beta Cell Survival after Subcutaneous Transplantation
[Cell Stem Cell] The authors combined a chemical screen with scRNA-seq to perform Chemical Perturb-seq (ChemPerturb-seq), enabling a systematic analysis of the molecular changes of human beta cells upon individual small molecule treatments.
NGN3 Oscillatory Expression Controls the Timing of Human Pancreatic Endocrine Differentiation
[Developmental Cell] Scientists investigated the dynamics and decoding of NEUROGENIN3 (NGN3), a transcription factor critical for pancreatic endocrine development.
Single-Cell Lipidomics by LC-MS Interlaboratory Study Reveals the Impact of X-Ray Irradiation on a Pancreatic Cancer Cell Line and Its Bystanders
[Analytical Chemistry] Researchers presented a novel workflow to enable interlaboratory studies, comprising live-cell imaging and single-cell isolation, followed by freeze-drying, international shipping, reconstitution, and untargeted lipidomics analysis.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.