REMD Biotherapeutics Completes Enrollment and Announces Top-line Results of a Phase II Clinical Study of Volagidemab (REMD-477) in Patients with Type 1 Diabetes

REMD Biotherapeutics, Inc., together with its subsidiary, Beijing CoSci-REMD Bio Med-Tech Co, Ltd, announced they have completed enrollment and have top-line results in a Phase II study of volagidemab (REMD-477) in patients with type 1 diabetes. The study is a randomized, placebo-controlled, double-blind study to evaluate the safety, efficacy, and pharmacodynamics of volagidemab at 35 mg and 70 mg in patients with type 1 diabetes who are currently receiving insulin treatment.
[REMD Biotherapeutics, Inc. (Business Wire, Inc.)]
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Metabolic Messengers: Glucagon-Like Peptide 1

Scientists provide a concise overview of the core physiology of glucagon like peptide-1 secretion and action, and the role of the peptide in human health, disease and therapeutics.
[Nature Metabolism]
Gribble, F. M., & Reimann, F. (2021). Metabolic Messengers: glucagon-like peptide 1. Nature Metabolism, 1–7. https://doi.org/10.1038/s42255-020-00327-x Cite
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High-Fat Diet-Induced Upregulation of Exosomal Phosphatidylcholine Contributes to Insulin Resistance

The authors showed that lean mice became insulin resistant after being administered exosomes isolated from the feces of obese mice fed a high-fat diet or from patients with type II diabetes.
[Nature Communications]
Kumar, A., Sundaram, K., Mu, J., Dryden, G. W., Sriwastva, M. K., Lei, C., Zhang, L., Qiu, X., Xu, F., Yan, J., Zhang, X., Park, J. W., Merchant, M. L., Bohler, H. C. L., Wang, B., Zhang, S., Qin, C., Xu, Z., Han, X., … Zhang, H.-G. (2021). High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance. Nature Communications, 12(1), 213. https://doi.org/10.1038/s41467-020-20500-w Cite
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ABCA8-Mediated Efflux of Taurocholic Acid Contributes to Gemcitabine Insensitivity in Human Pancreatic Cancer via the S1PR2-ERK Pathway

Researchers found that the expression of ABCA8, a member of ABCA subfamily transporters, was significantly increased in human pancreatic cancer (PC) cells after gemcitabine (GEM) treatment, as well as in established GEM-resistant PC cells.
[Cell Death Discovery]
Yang, C., Yuan, H., Gu, J., Xu, D., Wang, M., Qiao, J., Yang, X., Zhang, J., Yao, M., Gu, J., Tu, H., & Gan, Y. (2021). ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway. Cell Death Discovery, 7(1), 1–12. https://doi.org/10.1038/s41420-020-00390-z Cite
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Mitochondrial Gene Expression in Single Cells Shape Pancreatic Beta Cells’ Sub-Populations and Explain Variation in Insulin Pathway

Cluster analysis revealed two distinct human beta cell populations, which diverged by mitochondrial and nuclear DNA-encoded oxidative phosphorylation gene expression in healthy and diabetic individuals, and in newborn but not in adult mice.
[Scientific Reports]
Medini, H., Cohen, T., & Mishmar, D. (2021). Mitochondrial gene expression in single cells shape pancreatic beta cells’ sub-populations and explain variation in insulin pathway. Scientific Reports, 11(1), 466. https://doi.org/10.1038/s41598-020-80334-w Cite
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The EGFR-HSF1 Axis Accelerates the Tumorigenesis of Pancreatic Cancer

Investigators clarified the mechanisms on early activation of heat shock factor 1 (HSF1) and its role in the pancreatic cancer tumorigenesis.
[Journal of Experimental & Clinical Cancer Research]
Qian, W., Chen, K., Qin, T., Xiao, Y., Li, J., Yue, Y., Zhou, C., Ma, J., Duan, W., Lei, J., Han, L., Li, L., Shen, X., Wu, Z., Ma, Q., & Wang, Z. (2021). The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer. Journal of Experimental & Clinical Cancer Research, 40(1), 25. https://doi.org/10.1186/s13046-020-01823-4 Cite
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Targeting STAT3 by a Small Molecule Suppresses Pancreatic Cancer Progression

Researchers report a new small-molecule inhibitor with potent antitumor bioactivity, which inhibited multiple oncogenic processes in pancreatic cancer.
[Oncogene]
Chen, H., Bian, A., Yang, L., Yin, X., Wang, J., Ti, C., Miao, Y., Peng, S., Xu, S., Liu, M., Qiu, W.-W., & Yi, Z. (2021). Targeting STAT3 by a small molecule suppresses pancreatic cancer progression. Oncogene, 1–18. https://doi.org/10.1038/s41388-020-01626-z Cite
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MiR-10b-5p Rescues Diabetes and Gastrointestinal Dysmotility

The authors performed miRNA-seq analysis from isolated Interstitial cells of Cajal (ICCs) in diabetic mice and plasma from patients with idiopathic and diabetic gastroparesis.
[Gastroenterology]
MiR-10b-5p Rescues Diabetes and Gastrointestinal Dysmotility - Gastroenterology. (n.d.). Retrieved January 11, 2021, from https://www.gastrojournal.org/article/S0016-5085(21)00001-9/abstract Cite
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Zinc Dependent Regulation of ZEB1 and YAP1 Co-Activation Promotes EMT Plasticity and Metastasis in Pancreatic Cancer

Scientists demonstrated that ZIP4 activated ZEB1 and YAP1 through distinct mechanisms. The ZIP4-miR-373-LATS2-ZEB1/YAP1-ITGA3 signaling axis has a significant impact on pancreatic cancer metastasis and EMT plasticity.
[Gastroenterology]
Liu, M., Zhang, Y., Yang, J., Zhan, H., Zhou, Z., Jiang, Y., Shi, X., Fan, X., Zhang, J., Luo, W., Fung, K.-M. A., Xu, C., Bronze, M. S., Houchen, C. W., & Li, M. (2021). Zinc Dependent Regulation of ZEB1 and YAP1 Co-activation Promotes EMT Plasticity and Metastasis in Pancreatic Cancer. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2020.12.077 Cite
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CREPT Is Required for Murine Stem Cell Maintenance during Intestinal Regeneration

Scientists report that CREPT, a recently identified tumor-promoting protein, was required for the maintenance of murine intestinal stem cells. CREPT was preferably expressed in the crypts but not in the villi.
[Nature Communications]
Yang, L., Yang, H., Chu, Y., Song, Y., Ding, L., Zhu, B., Zhai, W., Wang, X., Kuang, Y., Ren, F., Jia, B., Wu, W., Ye, X., Wang, Y., & Chang, Z. (2021). CREPT is required for murine stem cell maintenance during intestinal regeneration. Nature Communications, 12(1), 270. https://doi.org/10.1038/s41467-020-20636-9 Cite
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Engineering Human Hepato-Biliary-Pancreatic Organoids from Pluripotent Stem Cells

Investigators describe a protocol for the continuous patterning of hepatic, biliary and pancreatic structures from a 3D culture of human pluripotent stem cells.
[Nature Protocols]
Koike, H., Iwasawa, K., Ouchi, R., Maezawa, M., Kimura, M., Kodaka, A., Nishii, S., Thompson, W. L., & Takebe, T. (2021). Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells. Nature Protocols, 1–18. https://doi.org/10.1038/s41596-020-00441-w Cite
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