Development of a 3D Atlas of the Embryonic Pancreas for Topological and Quantitative Analysis of Heterologous Cell Interactions

Scientists presented a light-sheet fluorescence microscopy approach to image the pancreas in 3D and map tissue interactions at key time points in the mouse embryo.
[Development]
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The Idd2 Locus Confers Prominent Resistance to Autoimmune Diabetes

Researchers generated a NOD congenic mouse bearing B10 resistance alleles on chromosome 9 in a locus coinciding with part of the insulin-dependent diabetes (Idd) locus and found that NOD.
[Journal of Immunology]
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Aminopyridine Analogs Selectively Target Metastatic Pancreatic Cancer

6-aminopicolamine (6AP) acted as a water-soluble prodrug that was converted into intracellular bioactive metabolites that inhibited phosphogluconate dehydrogenase in vitro, and 6AP monotherapy demonstrated anti-metastatic efficacy with minimal toxicity in vivo.
[Oncogene]
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Zai Lab Announces First Patient Treated in Greater China in PANOVA-3 Phase III Pivotal Trial of Tumor Treating Fields in Pancreatic Cancer

Zai Lab Limited announced treatment of the first patient in Greater China in the PANOVA-3 trial, a Phase III pivotal trial of Tumor Treating Fields in patients with pancreatic cancer.
[Zai Lab Limited]
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Analysis of the Glyco-Code in Pancreatic Ductal Adenocarcinoma Identifies Glycan-Mediated Immune Regulatory Circuits

By analysing publicly available transcriptomic data of patient samples and cell lines, researchers identified here two specific glycan profiles in pancreatic ductal adenocarcinoma that correlated with progression, clinical outcome and epithelial to mesenchymal transition status.
[Communications Biology]
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Multimodal Evaluation of 19F-BPA Internalization in Pancreatic Cancer Cells for Boron Capture and Proton Therapy Potential Applications

Researchers evaluated the in vitro internalization of the 19F-labelled p-boronophenylalanine (19F-BPA) in the human cancer pancreatic cell line for the potential application of Boron Neutron Capture Therapy and Proton Boron Fusion Therapy in pancreatic cancer.
[Physica Medica-European Journal of Medical Physics]
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Inter-Organ Crosstalk in Pancreatic Islet Function and Pathology

Scientists discuss recent advances in inter-organ communication from the metabolic, immune, and neural system to pancreatic islets, their biological implication in normal pancreas endocrine function, as well as their role in the adaptive responses of islet to nutrition-induced stress.
[Febs Letters]
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Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to Fuel Tumour Progression

Researchers demonstrated that PDAC tumors established an organised communication network between subpopulations of cancer cells using EVs called the EVNet.
[Gut]
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Grainyhead 1 Acts as a Drug-Inducible Conserved Transcriptional Regulator Linked to Insulin Signaling and Lifespan

Researchers showed that increased expression of the transcription factor Grainyhead 1 promoted lifespan and pathogen resistance in Caenorhabditis elegans.
[Nature Communications]
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Biomea Fusion Announces 2022 Clinical Development Plan to Initiate Studies in Up to Seven Different Tumor Types and in Diabetes for BMF-219

Biomea Fusion, Inc. announced that in 2022 it plans to initiate clinical studies to dose its irreversible covalent menin inhibitor, BMF-219, in up to seven different cancer indications as well as in diabetes.
[Biomea Fusion, Inc.]
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Organization and Dynamics of the Cortical Complexes Controlling Insulin Secretion in β-Cells

Researchers showed that insulin secretion sites also contain non-neuronal proteins LL5β and KANK1, which in migrating cells organize exocytotic machinery in the vicinity of integrin-based adhesions.
[Journal of Cell Science]
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