Category Archives: Pancreatic Cell

Pancreatic Cell News is an online publication and email newsletter providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
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Pancreatic Cell News is a weekly newsletter that highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.

REMD Biotherapeutics Completes Enrollment and Announces Top-line Results of a Phase II Clinical Study of Volagidemab (REMD-477) in Patients with Type 1 Diabetes

REMD Biotherapeutics, Inc., together with its subsidiary, Beijing CoSci-REMD Bio Med-Tech Co, Ltd, announced they have completed enrollment and have top-line results in a Phase II study of volagidemab (REMD-477) in patients with type 1 diabetes. The study is a randomized, placebo-controlled, double-blind study to evaluate the safety, efficacy, and pharmacodynamics of volagidemab at 35 mg and 70 mg in patients with type 1 diabetes who are currently receiving insulin treatment.
[REMD Biotherapeutics, Inc. (Business Wire, Inc.)]
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Metabolic Messengers: Glucagon-Like Peptide 1

Scientists provide a concise overview of the core physiology of glucagon like peptide-1 secretion and action, and the role of the peptide in human health, disease and therapeutics.
[Nature Metabolism]
Gribble, F. M., & Reimann, F. (2021). Metabolic Messengers: glucagon-like peptide 1. Nature Metabolism, 1–7. https://doi.org/10.1038/s42255-020-00327-x Cite
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High-Fat Diet-Induced Upregulation of Exosomal Phosphatidylcholine Contributes to Insulin Resistance

The authors showed that lean mice became insulin resistant after being administered exosomes isolated from the feces of obese mice fed a high-fat diet or from patients with type II diabetes.
[Nature Communications]
Kumar, A., Sundaram, K., Mu, J., Dryden, G. W., Sriwastva, M. K., Lei, C., Zhang, L., Qiu, X., Xu, F., Yan, J., Zhang, X., Park, J. W., Merchant, M. L., Bohler, H. C. L., Wang, B., Zhang, S., Qin, C., Xu, Z., Han, X., … Zhang, H.-G. (2021). High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance. Nature Communications, 12(1), 213. https://doi.org/10.1038/s41467-020-20500-w Cite
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ABCA8-Mediated Efflux of Taurocholic Acid Contributes to Gemcitabine Insensitivity in Human Pancreatic Cancer via the S1PR2-ERK Pathway

Researchers found that the expression of ABCA8, a member of ABCA subfamily transporters, was significantly increased in human pancreatic cancer (PC) cells after gemcitabine (GEM) treatment, as well as in established GEM-resistant PC cells.
[Cell Death Discovery]
Yang, C., Yuan, H., Gu, J., Xu, D., Wang, M., Qiao, J., Yang, X., Zhang, J., Yao, M., Gu, J., Tu, H., & Gan, Y. (2021). ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway. Cell Death Discovery, 7(1), 1–12. https://doi.org/10.1038/s41420-020-00390-z Cite
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Mitochondrial Gene Expression in Single Cells Shape Pancreatic Beta Cells’ Sub-Populations and Explain Variation in Insulin Pathway

Cluster analysis revealed two distinct human beta cell populations, which diverged by mitochondrial and nuclear DNA-encoded oxidative phosphorylation gene expression in healthy and diabetic individuals, and in newborn but not in adult mice.
[Scientific Reports]
Medini, H., Cohen, T., & Mishmar, D. (2021). Mitochondrial gene expression in single cells shape pancreatic beta cells’ sub-populations and explain variation in insulin pathway. Scientific Reports, 11(1), 466. https://doi.org/10.1038/s41598-020-80334-w Cite
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The EGFR-HSF1 Axis Accelerates the Tumorigenesis of Pancreatic Cancer

Investigators clarified the mechanisms on early activation of heat shock factor 1 (HSF1) and its role in the pancreatic cancer tumorigenesis.
[Journal of Experimental & Clinical Cancer Research]
Qian, W., Chen, K., Qin, T., Xiao, Y., Li, J., Yue, Y., Zhou, C., Ma, J., Duan, W., Lei, J., Han, L., Li, L., Shen, X., Wu, Z., Ma, Q., & Wang, Z. (2021). The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer. Journal of Experimental & Clinical Cancer Research, 40(1), 25. https://doi.org/10.1186/s13046-020-01823-4 Cite
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Targeting STAT3 by a Small Molecule Suppresses Pancreatic Cancer Progression

Researchers report a new small-molecule inhibitor with potent antitumor bioactivity, which inhibited multiple oncogenic processes in pancreatic cancer.
[Oncogene]
Chen, H., Bian, A., Yang, L., Yin, X., Wang, J., Ti, C., Miao, Y., Peng, S., Xu, S., Liu, M., Qiu, W.-W., & Yi, Z. (2021). Targeting STAT3 by a small molecule suppresses pancreatic cancer progression. Oncogene, 1–18. https://doi.org/10.1038/s41388-020-01626-z Cite
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MiR-10b-5p Rescues Diabetes and Gastrointestinal Dysmotility

The authors performed miRNA-seq analysis from isolated Interstitial cells of Cajal (ICCs) in diabetic mice and plasma from patients with idiopathic and diabetic gastroparesis.
[Gastroenterology]
MiR-10b-5p Rescues Diabetes and Gastrointestinal Dysmotility - Gastroenterology. (n.d.). Retrieved January 11, 2021, from https://www.gastrojournal.org/article/S0016-5085(21)00001-9/abstract Cite
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Zinc Dependent Regulation of ZEB1 and YAP1 Co-Activation Promotes EMT Plasticity and Metastasis in Pancreatic Cancer

Scientists demonstrated that ZIP4 activated ZEB1 and YAP1 through distinct mechanisms. The ZIP4-miR-373-LATS2-ZEB1/YAP1-ITGA3 signaling axis has a significant impact on pancreatic cancer metastasis and EMT plasticity.
[Gastroenterology]
Liu, M., Zhang, Y., Yang, J., Zhan, H., Zhou, Z., Jiang, Y., Shi, X., Fan, X., Zhang, J., Luo, W., Fung, K.-M. A., Xu, C., Bronze, M. S., Houchen, C. W., & Li, M. (2021). Zinc Dependent Regulation of ZEB1 and YAP1 Co-activation Promotes EMT Plasticity and Metastasis in Pancreatic Cancer. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2020.12.077 Cite
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CREPT Is Required for Murine Stem Cell Maintenance during Intestinal Regeneration

Scientists report that CREPT, a recently identified tumor-promoting protein, was required for the maintenance of murine intestinal stem cells. CREPT was preferably expressed in the crypts but not in the villi.
[Nature Communications]
Yang, L., Yang, H., Chu, Y., Song, Y., Ding, L., Zhu, B., Zhai, W., Wang, X., Kuang, Y., Ren, F., Jia, B., Wu, W., Ye, X., Wang, Y., & Chang, Z. (2021). CREPT is required for murine stem cell maintenance during intestinal regeneration. Nature Communications, 12(1), 270. https://doi.org/10.1038/s41467-020-20636-9 Cite
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Engineering Human Hepato-Biliary-Pancreatic Organoids from Pluripotent Stem Cells

Investigators describe a protocol for the continuous patterning of hepatic, biliary and pancreatic structures from a 3D culture of human pluripotent stem cells.
[Nature Protocols]
Koike, H., Iwasawa, K., Ouchi, R., Maezawa, M., Kimura, M., Kodaka, A., Nishii, S., Thompson, W. L., & Takebe, T. (2021). Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells. Nature Protocols, 1–18. https://doi.org/10.1038/s41596-020-00441-w Cite
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