T Cells Armed with C-X-C Chemokine Receptor Type 6 Enhance Adoptive Cell Therapy for Pancreatic Tumours

Researchers showed that forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer.
[Nature Biomedical Engineering]
Lesch, S., Blumenberg, V., Stoiber, S., Gottschlich, A., Ogonek, J., Cadilha, B. L., Dantes, Z., Rataj, F., Dorman, K., Lutz, J., Karches, C. H., Heise, C., Kurzay, M., Larimer, B. M., Grassmann, S., Rapp, M., Nottebrock, A., Kruger, S., Tokarew, N., … Kobold, S. (2021). T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours. Nature Biomedical Engineering, 1–15. https://doi.org/10.1038/s41551-021-00737-6 Cite
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Valosin-Containing Protein Stabilizes Mutant p53 to Promote Pancreatic Cancer Growth

The authors identified valosin-containing protein as a regulator of p53-R273H by conducting immunoprecipitation-tandem mass spectrometry analysis. VCP bound p53-R273H at its DNA binding domain.
[Cancer Research]
Wang, J., Chen, Y., Huang, C., Hao, Q., Zeng, S. X., Omari, S., Zhang, Y., Zhou, X., & Lu, H. (2021). Valosin-containing protein stabilizes mutant p53 to promote pancreatic cancer growth. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-3855 Cite
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Exosomal Linc-ROR Mediates Crosstalk between Cancer Cells and Adipocytes to Promote Tumor Growth in Pancreatic Cancer

The effects of conditioned medium collected from dedifferentiated adipocytes on pancreatic cancer cell proliferation, motility, metastasis and epithelial-mesenchymal transition (EMT) were evaluated by western blot analysis, colony forming, real-time cell analysis, 5-ethynyl-2’-deoxyuridine, immunofluorescence, Transwell and wound healing assays in vitro.
[Molecular Therapy-Nucleic Acids]
Sun, Z., Sun, D., Feng, Y., Zhang, B., Sun, P., Zhou, B., Du, L., Wang, Y., Fan, Z., Yang, J., Li, Y., Hu, S., & Zhan, H. (2021). Exosomal Linc-ROR Mediates Crosstalk between Cancer Cells and Adipocytes to Promote Tumor Growth in Pancreatic Cancer. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.06.001 Cite
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Sunitinib-Loaded Chondroitin Sulfate Hydrogels as a Novel Drug-Delivery Mechanism for the Treatment of Pancreatic Neuroendocrine Tumors

Researchers hypothesized that a new drug delivery system comprising chondroitin sulfate hydrogels loaded with sunitinib suppressed tumor growth in PanNET cells.
[Translational Research]
Keutgen, X. M., Ornell, K. J., Vogle, A., Lakiza, O., Williams, J., Miller, P., Mistretta, K. S., Setia, N., Weichselbaum, R. R., & Coburn, J. M. (2021). Sunitinib-Loaded Chondroitin Sulfate Hydrogels as a Novel Drug-Delivery Mechanism for the Treatment of Pancreatic Neuroendocrine Tumors. Annals of Surgical Oncology. https://doi.org/10.1245/s10434-021-10245-1 Cite
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Complement Factor B Regulates Cellular Senescence and Is Associated with Poor Prognosis in Pancreatic Cancer

Scientists performed secretome analyses of culture media of mouse pancreatic intraepithelial neoplasia and PDAC cells using Stable Isotope Labeling by Amino acid in Cell culture with click chemistry and liquid chromatography-mass spectrometry.
[Cellular Oncology]
Shimazaki, R., Takano, S., Satoh, M., Takada, M., Miyahara, Y., Sasaki, K., Yoshitomi, H., Kagawa, S., Furukawa, K., Takayashiki, T., Kuboki, S., Sogawa, K., Motohashi, S., Nomura, F., Miyazaki, M., & Ohtsuka, M. (2021). Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer. Cellular Oncology. https://doi.org/10.1007/s13402-021-00614-z Cite
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miR-194-5p Down-Regulates Tumor Cell PD-L1 Expression and Promotes Anti-tumor Immunity in Pancreatic Cancer

Investigators found that high expression of miR-194-5p in human pancreatic cancer patients is associated with a better survival rate, while increased expression of programmed cell death ligand 1 in human pancreatic cancer patients is associated with a worse survival rate.
[International Immunopharmacology]
miR-194-5p down-regulates tumor cell PD-L1 expression and promotes anti-tumor immunity in pancreatic cancer. (2021). International Immunopharmacology, 97, 107822. https://doi.org/10.1016/j.intimp.2021.107822 Cite
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Tumor Suppressive Role of miR-33a-5p in Pancreatic Ductal Adenocarcinoma Cells by Directly Targeting RAP2A

Researchers observed for the first time that miR-33a-5p expression level was significantly decreased in pancreatic ductal adenocarcinoma tissues and cell lines.
[Cellular & Molecular Biology Letters]
Lian, Y., Jiang, D., & Sun, J. (2021). Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A. Cellular & Molecular Biology Letters, 26(1), 24. https://doi.org/10.1186/s11658-021-00265-w Cite
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Early Detection of Pancreatic Cancer Using DNA-Based Molecular Approaches

Investigators discuss and focus on the pathological and molecular features of precancerous lesions of the pancreas, including pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm and mucinous cystic neoplasm, which are target lesions of early detection approaches.
[Nature Reviews Gastroenterology & Hepatology]
Singhi, A. D., & Wood, L. D. (2021). Early detection of pancreatic cancer using DNA-based molecular approaches. Nature Reviews Gastroenterology & Hepatology, 1–12. https://doi.org/10.1038/s41575-021-00470-0 Cite
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The Pancreatic Cancer Genome Revisited

Given the vast developments within this field, scientists review the wide-ranging and most current information related to pancreatic cancer genomics with the goal of integrating this information into a unifying description of the life history of pancreatic cancer.
[Nature Reviews Gastroenterology & Hepatology]
Hayashi, A., Hong, J., & Iacobuzio-Donahue, C. A. (2021). The pancreatic cancer genome revisited. Nature Reviews Gastroenterology & Hepatology, 1–13. https://doi.org/10.1038/s41575-021-00463-z Cite
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Exploring the Complementarity of Pancreatic Ductal Adenocarcinoma Preclinical Models

Three paired pancreatic ductal adenocarcinoma preclinical models-patient-derived xenografts , xenograft-derived pancreatic organoids and xenograft-derived primary cell cultures-were derived from 20 patients and analyzed at the transcriptomic and chemosensitivity level.
[Cancers]
Hoare, O., Fraunhoffer, N., Elkaoutari, A., Gayet, O., Bigonnet, M., Roques, J., Nicolle, R., McGuckin, C., Forraz, N., Sohier, E., Tonon, L., Wajda, P., Boyault, S., Attignon, V., Tabone-Eglinger, S., Barbier, S., Mignard, C., Duchamp, O., Iovanna, J., & Dusetti, N. J. (2021). Exploring the Complementarity of Pancreatic Ductal Adenocarcinoma Preclinical Models. Cancers, 13(10), 2473. https://doi.org/10.3390/cancers13102473 Cite
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DayTwo, a Leader in Precision Medicine with the World’s Largest Microbiome Discovery Platform, Announces New Behavioral Science Approach for Diabetes Care

DayTwo, Inc. announced that it has launched a unique methodology for addressing depression in people with diabetes. The new solution, called EATS uses psychological techniques to overcome emotional barriers to chronic condition management.
[DayTwo, Inc. (Business Wire, Inc.)]
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