Foreign Researchers Accused of Hiding Links to Chinese Military

Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
[The Scientist]
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A G-Quadruplex-Binding Compound Shows Potent Activity in Human Gemcitabine-Resistant Pancreatic Cancer Cells

Scientists report on cell lines of increased resistance to gemcitabine that have been generated from this line, with the most resistant having 1,000-fold reduced sensitivity to gemcitabine.
[Scientific Reports]
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Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL-2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics

Researchers report that PRMT1 expression is increased in pancreatic cancer tissues and associated with higher tumor grade, increased aggressiveness and worse prognosis.
[Cancer Research]
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Clinical Trials Rebound After COVID-19 Crash, but Can Enrollment Gains Continue?

For the hundreds of thousands of people enrolling in clinical trials every year—and for whom experimental therapies can offer a last hope—a new report provides some welcome news: Enrollment in clinical studies in the United States is on the rebound after disruptions caused by the COVID-19 pandemic.
[ScienceInsider]
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Science Money Slashed in EU’s €1.8-Trillion Budget Deal

A historic €1.8-trillion (US$2.1-trillion) budget deal reached by European Union (EU) leaders to fund its next seven years — and its recovery from the coronavirus pandemic — has left scientists and research advocates disappointed.
[Nature News]
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Epigenetics in Modulating Immune Functions of Stromal and Immune Cells in the Tumor Microenvironment

The authors review recent studies demonstrating how specific epigenetic mechanisms drive aspects of stromal and immune cell differentiation with implications for the development of solid tumor therapeutics, focusing on the pancreatic ductal adenocarcinoma tumor microenvironment as a representative of solid tumors.
[Cellular & Molecular Immunology]
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CalciMedica and EpiPharma Enter into Research Collaboration to Discover and Develop CRAC Channel Inhibitor Therapies

CalciMedica and EpiPharma announced that they have entered into a collaboration agreement to use EpiPharma’s state-of-the-art pre-Clinical Drug Testing and Diagnostics Laboratory Platform to accelerate the discovery and development of CalciMedica’s CRAC channel inhibitor novel drug pipeline.
[CalciMedica]
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Tectorigenin Enhances PDX1 Expression and Protects Pancreatic β-Cells by Activating ERK and Reducing ER Stress

Investigators found that tectorigenin could suppress induced apoptosis and improved the viability of β-cells under glucotoxicity and lipotoxicity by activation of ERK and reduction of reactive oxygen species and endoplasmic reticulum stress.
[Journal of Biological Chemistry]
Yao, X., Li, K., Liang, C., Zhou, Z., Wang, J., Wang, S., Liu, L., Yu, C.-L., Song, Z.-B., Bao, Y.-L., Zheng, L.-H., Sun, Y., Wang, G., Huang, Y., Yi, J., Sun, L., & Li, Y. (2020). Tectorigenin enhances PDX1 expression and protects pancreatic β-cells by activating ERK and reducing ER stress. Journal of Biological Chemistry, jbc.RA120.012849. https://doi.org/10.1074/jbc.RA120.012849 Cite
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UAE1 Inhibition Mediates the Unfolded Protein Response, DNA Damage and Caspase-Dependent Cell Death in Pancreatic Cancer

Inhibition of ubiquitin activating enzyme 1 (UAE1) activity in response to TAK-243 led to an accumulation of misfolded proteins within the endoplasmic reticulum (ER), thereby aggravating ER stress, leading to DNA damage and arrest of cells in the G2/M phase of the cell cycle.
[Translational Oncology]
UAE1 inhibition mediates the unfolded protein response, DNA damage and caspase-dependent cell death in pancreatic cancer - ScienceDirect. (n.d.). Retrieved July 21, 2020, from https://www.sciencedirect.com/science/article/pii/S1936523320303260?via%3Dihub Cite
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The USP22 Promotes the Growth of Cancer Cells through the DYRK1A in Pancreatic Ductal Adenocarcinoma

Scientists report that USP22 promoted the growth of pancreatic ductal adenocarcinoma cells by promoting the expression of dual-specificity tyrosine regulated kinase 1A.
[Gene]
Bai, Z., Du, Y., Cong, L., & Cheng, Y. (2020). The USP22 promotes the growth of cancer cells through the DYRK1A in pancreatic ductal adenocarcinoma. Gene, 144960. https://doi.org/10.1016/j.gene.2020.144960 Cite
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Basal-Like and Classical Cells Coexist in Pancreatic Cancer Revealed by Single-Cell Analysis on Biopsy-Derived Pancreatic Cancer Organoids from the Classical Subtype

The authors performed single‐cell transcriptomic analyses using combinational barcoding exclusively on epithelial cells from six different classical pancreatic ductal adenocarcinoma patients obtained by Endoscopic Ultrasound with Fine Needle Aspiration.
[FASEB Journal]
Juiz, N., Elkaoutari, A., Bigonnet, M., Gayet, O., Roques, J., Nicolle, R., Iovanna, J., & Dusetti, N. (n.d.). Basal-like and classical cells coexist in pancreatic cancer revealed by single-cell analysis on biopsy-derived pancreatic cancer organoids from the classical subtype. The FASEB Journal, n/a(n/a). https://doi.org/10.1096/fj.202000363RR Cite
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The Role of Genetic Polymorphism within PD-L1 Gene in Cancer

The expression of PD-L1 in tumors has been described in many histological types of cancer: melanoma, lung cancer, breast and ovarian, pancreatic and esophagus adenocarcinoma, kidney tumors and bladder cancers as well as in hematopoietic malignancies.
[Experimental and Molecular Pathology]
Kula, A., Dawidowicz, M., Kiczmer, P., Seńkowska, A. P., & Świętochowska, E. (2020). The role of genetic polymorphism within PD-L1 gene in cancer. Review. Experimental and Molecular Pathology, 104494. https://doi.org/10.1016/j.yexmp.2020.104494 Cite
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