RUNX2 and LAMC2: Promising Pancreatic Cancer Biomarkers Identified by an Integrative Data Mining of Pancreatic Adenocarcinoma Tissues

Pancreatic carcinoma (PC) is a severe disease associated with high mortality. To identify biomarkers for early diagnosis and therapy, three mRNA microarray datasets and two miRNA datasets were selected, and combinative analysis was performed by GEO2R.
[Aging]
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The Molecular Mechanism of Vgf in Appetite, Lipids, and Insulin Regulation

The mechanisms of obesity and diabetes and the crosstalk between these diseases are still ambiguous. The authors clarified and explained the role of VGF peptides in the brain, pancreas, and adipose tissue in the development of obesity.
[Pharmacological Research]
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Detecting Insulitis in Type 1 Diabetes with Ultrasound Phase-Change Contrast Agents

Researchers presented ultrasound imaging of nanodroplet (ND) contrast-agent accumulation within the islet. ND accumulation is dependent on immune infiltration; therefore, it tracked presymptomatic type I diabetes development and progression to diabetes
[Proceedings of the National Academy of Sciences of the United States of America]
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1α, 25-(OH)2 Vitamin D3 Prevents Insulin Resistance and Regulates Coordinated Exocytosis and Insulin Secretion

Researchers investigated the short-term effect of 1α,25(OH)2 vitamin D3 and cholecalciferol on the glycemia and insulin sensitivity of control and dexamethasone-induced insulin-resistance in rats.
[Journal of Nutritional Biochemistry]
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Precigen ActoBio Announces Additional Positive Interim Data from Phase 1b/2a Study of AG019 ActoBiotics™, a Novel Therapy Designed to Address the Underlying Cause of Type 1 Diabetes

Precigen ActoBio, announced additional positive interim data from the ongoing Phase 1b/2a clinical study investigating AG019 ActoBiotics for the treatment of recent-onset type 1 diabetes.
[Precigen ActoBio]
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ATP Synthase Inhibitory Factor Subunit 1 Regulates Islet β-Cell Function via Repression of Mitochondrial Homeostasis

ATP synthase inhibitory factor subunit 1 (IF1) is a mitochondrial protein interacting with ATP synthase to inhibit its enzyme activity. Scientists investigated islets freshly isolated from mouse lines with global inhibitory factor subunit 1 knockout (IF1−/−) and overexpression.
[Laboratory Investigation]
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A 584 BP Deletion in CTRB2 Inhibits Chymotrypsin B2 Activity and Secretion and Confers Risk of Pancreatic Cancer

Scientists proposed that intracellular accumulation of a nonfunctional chymotrypsinogen B2 protein led to endoplasmic reticulum stress and pancreatic inflammation, which might explain the increased pancreatic cancer risk in carriers of CTRB2 exon 6 deletion alleles.
[American Journal of Human Genetics]
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T.H.A.C Announces the Acquisition of an International Patent on Its Drug Candidate ALF-5755 for the Early Treatment of Type 2 Diabetes Mellitus and Relative to the Gut Microbiota Composition

T.H.A.C SA, a biopharmaceutical Company which develops a new class of drugs for the early treatment of type 2 diabetes mellitus (T2DM), announces the acquisition of an international patent submitted by INSERM, Hospitals of Paris, INRA and University of Paris. This patent protects the drug candidate of THAC and its use for the protection of oxygen sensitive bacteria, for example in the gut microbiota. The Company reserves the right to submit a divisionary application in the coming months.
[T.H.A.C SA (BusinessWire, Inc.)]
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Bioengineered 3D Models of Human Pancreatic Cancer Recapitulate In Vivo Tumor Biology

Researchers developed a comprehensive and highly tuneable ex vivo model of pancreatic ductal adenocarcinoma based on the 3D co-assembly of peptide amphiphiles with custom ECM components.
[Nature Communications]
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Long Noncoding RNA SOX2OT Promotes Pancreatic Cancer Cell Migration and Invasion through Destabilizing FUS Protein via Ubiquitination

Scientists performed RNA pull-down, cycloheximide-chase, and ubiquitination assays to determine the effect of SOX2OT on FUS ubiquitination, and explored the specific regulatory mechanism of SOX2OT–FUS axis in pancreatic cancer cell migration, invasion, in vivo tumor growth, and metastasis through RNA sequencing.
[Cell Death Discovery]
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Long Non-coding RNA ZFAS1 Promotes Pancreatic Cancer Proliferation and Metastasis by Sponging miR-497-5p to Regulate HMGA2 Expression

Scientists identified the role and molecular mechanisms of ZFAS1 in pancreatic cancer. The expression of ZFAS1, miR-497-5p and HMGA2 in pancreatic cancer tissues was detected by qRT-PCR.
[Cell Death Discovery]
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