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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Hsa_circ_0007590/PTBP1 Complex Reprograms Glucose Metabolism by Reducing the Stability of m6A-Modified PTEN mRNA in Pancreatic Ductal Adenocarcinoma
[Cancer Gene Therapy] Through RNA sequencing of cells cultured under conditions of glucose deprivation, researchers identified hsa_circ_0007590. Hsa_circ_0007590 facilitated the proliferation, migration, and invasion of PDAC cells and promoted the Warburg effect.
HSP70-Mediated Mitochondrial Dynamics and Autophagy Represent a Novel Vulnerability in Pancreatic Cancer
[Cell Death & Differentiation] The authors reported that PDAC has the highest expression of HSP70 relative to normal tissue across all cancers analyzed. Genetic or therapeutic ablation of HSP70 altered mitochondrial subcellular localization, impaired mitochondrial dynamics, and promoted mitochondrial swelling to induce apoptosis.
Long-Chain Fatty Acids – the Turning Point between ‘Mild’ and ‘Severe’ Acute Pancreatitis
[Heliyon] The authors provide a comprehensive analysis of lipases' roles in the onset and progression of acute pancreatitis, as well as the effects of long-chain fatty acids on the function of pancreatic acinar cells.
KDM5B Promotes SMAD4 Loss-Driven Drug Resistance through Activating DLG1/YAP to Induce Lipid Accumulation in Pancreatic Ductal Adenocarcinoma
[Cell Death Discovery] Investigators reported that the loss of suppressor of mothers against decapentaplegic homolog (SMAD4) endowed PDAC cells the ability to drug resistance through upregulating histone lysine demethylase, lysine-specific demethylase 5B (KDM5B).
Dual Starvations Induce Pyroptosis for Orthotopic Pancreatic Cancer Therapy through Simultaneous Deprivation of Glucose and Glutamine
[Journal of The American Chemical Society] Scientists identified the vital genes glucose transporter 1 (GLUT1) and alanine-serine-cysteine transporter 2 (ASCT2) through bioinformatics analysis. Human serum albumin nanoparticles for delivery of GLUT1 and ASCT2 inhibitors were prepared by a self-assembly process.
FBXO32 Stimulates Protein Synthesis to Drive Pancreatic Cancer Progression and Metastasis
[Cancer Research] Researchers identified FBXO32 as an oncogenic driver in PDAC. FBXO32 was aberrantly upregulated in PDAC, and high FBXO32 expression was significantly associated with an unfavorable prognosis in PDAC patients.
The Bacterial Metabolite, Lithocholic Acid, Has Antineoplastic Effects in Pancreatic Adenocarcinoma
[Cell Death Discovery] The authors assessed the possible role of lithocholic acid (LCA) in pancreatic adenocarcinoma, and reported that LCA induced a multi-pronged antineoplastic program in pancreatic adenocarcinoma cells. LCA inhibited cancer cell proliferation and induced mesenchymal-to-epithelial transition that reduced cell invasion capacity.
SRI Earns FDA Orphan Drug Designation for Pancreatic Cancer
[SRI International] SRI’s Targeted Antigen Loaded Liposomes — a treatment that expands the benefits of immunotherapy such as check-point inhibitors — has been granted Orphan Drug Designation for PDAC by the US FDA.
Pancreatic Cancer Research Receives $8M Philanthropic Funding Boost
[Walter and Eliza Hall Institute of Medical Research] An exceptional $8 million, 10-year philanthropic investment will spearhead new treatments for pancreatic cancer and create a new dedicated research centre at Walter and Eliza Hall Institute of Medical Research.
The Peptidoglycan Recognition Protein 1 Confers Immune Evasive Properties on Pancreatic Cancer Stem Cells
[Gut] Researchers used a mouse model and primary tumour cell lines to investigate putative cancer stem cell (CSC) populations. They established peptidoglycan recognition protein 1 (PGLYRP1) as a novel CSC-associated marker crucial for immune evasion.
Allysine-Targeted Molecular MRI Enables Early Prediction of Chemotherapy Response in Pancreatic Cancer
[Cancer Research] Investigators reported the application of an allysine-targeted molecular magnetic resonance imaging probe, MnL3, to provide an early, noninvasive assessment of treatment response in PDAC. Molecular MRI with MnL3 could specifically detect and quantify fibrogenesis in PDAC xenografts.
Obg-Like ATPase 1 Exacerbated Gemcitabine Drug Resistance of Pancreatic Cancer
[iScience] Scientists investigated the molecular mechanism of obg-like ATPase 1 (OLA1) underlying gemcitabine (GEM)-induced drug resistance. An enhanced expression of OLA1 was observed in a GEM acquired resistant pancreatic cancer cell lines and in patients with pancreatic cancer.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
