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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
P2X7R and P2X4R Expression of Mice Submandibular Gland in High-Fat Diet/Streptozotocin-Induced Type 2 Diabetes
[Scientific Reports] Researchers evaluated P2X7R and P2X4R expression and morphological changes in the submandibular gland in type 2 diabetes mellitus.
Bax Inhibitor-1 Preserves Pancreatic β-Cell Proteostasis by Limiting Proinsulin Misfolding and Programmed Cell Death
[Cell Death & Disease] Investigators uncovered a new role for bax inhibitor-one, a negative regulator of inositol-requiring enzyme 1 in preserving β-cell health against terminal unfolded protein response (UPR)-induced apoptosis and pyroptosis in the context of supraphysiological loads of insulin production.
The Janus Kinase 1 Is Critical for Pancreatic Cancer Initiation and Progression
[Cell Reports] Using a ligand-controlled and pancreas-specific knockout in adult mice, researchers demonstrated that Janus tyrosine kinase (JAK1) deficiency prevented the formation of KRASG12D-induced pancreatic tumors. They established that JAK1 was essential for the constitutive activation of STAT3, whose activation is a prominent characteristic of PDAC.
Oncolytics Biotech® Receives Regulatory Clearance to Evaluate Pelareorep in Combination with Modified FOLFIRINOX +/- an Anti-PD-L1 Inhibitor in Pancreatic Cancer
[Oncolytics Biotech, Inc.] Oncolytics Biotech® Inc. will commence enrollment into a new GOBLET study pancreatic cancer cohort following both German regulatory and ethics approvals. This cohort will evaluate pelareorep in combination with modified FOLFIRINOX with or without the PD-L1 immune checkpoint inhibitor atezolizumab in newly diagnosed patients with PDAC.
SUCNR1 Regulates Insulin Secretion and Glucose Elevates the Succinate Response in People with Prediabetes
[Journal Of Clinical Investigation] Scientists reported that the succinate receptor (SUCNR1) was expressed in β-cells and was up-regulated in hyperglycemic states in mice and humans.
Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial–Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma
[Cancer Research] Researchers used a convergence approach to identify tumor cell and cancer-associated fibroblast interactions through the integration of single-cell data from human tumors with human organoid coculture experiments.
Positive Feedback Regulation between Glycolysis and Histone Lactylation Drives Oncogenesis in Pancreatic Ductal Adenocarcinoma
[Molecular Cancer] The participation of histone lactylation in the growth and progression of PDAC was confirmed through inhibition of histone lactylation by glycolysis inhibitors or lactate dehydrogenase A knockdown both in vitro and in vivo.
Acinar to β-Like Cell Conversion through Inhibition of Focal Adhesion Kinase
[Nature Communications] Using lineage tracing studies along with transcriptomic characterization, scientists demonstrated that treatment of adult mice with a small molecule that inhibits kinase activity of focal adhesion kinase resulted in trans-differentiation of a subset of peri-islet acinar cells into insulin producing β-like cells.
Adenosine Kinase Inhibits β-Cell Proliferation by Upregulating DNA Methyltransferase 3A Expression
[Diabetes Obesity & Metabolism] Genetic animal models and transgenic immortalized cells were applied to study the effect of adenosine kinase on islet beta-cell proliferation and function.
Pancreactic Cancer: Succesful Trial against Pancreatic Cancer with Defence’s Arm-002 Anti-cancer Vaccine
[Defence Therapeutics, Inc.] Defence Therapeutics, Inc. announce the completion of a pre-clinical vaccination trial using its ARM-002TM vaccine against pancreatic cancer. The vaccine was shown to be therapeutically effective against pre-established pancreatic cancer especially when combined with the anti-PD-1 immune-checkpoint inhibitor.
Multiplexed Imaging Mass Cytometry Analysis Characterizes the Vascular Niche in Pancreatic Cancer
[Cancer Research] Scientists investigated the vascular microenvironment of PDAC by applying imaging mass cytometry using a 26-antibody panel on 35 regions of interest across nine patients, capturing over 140,000 single cells.
Galectin-3 Impairs Calcium Transients and β-Cell Function
[Nature Communications] The authors reported that galectin-3, mainly produced and secreted by macrophages, was elevated in islets from both high-fat diet-fed and diabetic mice.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
