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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Reactive Oxygen Species-Instructed Supramolecular Assemblies Enable Bioorthogonally Activatable Protein Degradation for Pancreatic Cancer
[Journal of the American Chemical Society] Researchers presented a novel supramolecular self-assembly platform for the bioorthogonal control of PROTAC prodrug activation, enabling tumor-specific protein degradation with minimized systemic toxicity.
Endogenous Glucocorticoid Receptor Activation Modulates Early-Stage Cell Differentiation in Pancreatic Progenitors of Mice and Humans
[Development] The authors investigated glucocorticoid receptor signaling during early pancreas development in mice and humans.
Glucagon-Like Peptide-1 Receptor Agonists Use Does Not Increase the Risk for Acute Pancreatitis and Is Associated with Lower Complications in Patients with Type 2...
[American Journal of Gastroenterology] A retrospective cohort study was performed using population-based data from the TriNetX platform. T2DM patients receiving GLP-1 RAs drugs between January 1, 2015, and October 31, 2023 were included.
Genprex Signs Sponsored Research Agreement with the University of Pittsburgh to Study Diabetes Gene Therapy in Type 1 and Type 2 Diabetes
[Genprex, Inc. ] Genprex, Inc. announced that following the recent completion of its two-year Sponsored Research Agreement (SRA) with the University of Pittsburgh of the Commonwealth System of Higher Education to study T1D and T2D, the parties have entered into a new SRA to study GPX-002 in T1D and T2D in animal models.
Oxytocin Modulates Insulin and GLP-1 Secretion in Pancreatic Islets
[Aging-Us] Researchers measured changes in blood glucose and insulin levels following oxytocin (Oxt) administration in wild-type and Oxt receptor knockout mice.
FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development
[Cancer Research] Scientists found that the receptor tyrosine kinase FGFR2 was progressively upregulated in mutant KRAS-driven metaplasia, precancerous lesions, and classical PDAC.
Improving Outcomes of Patients with Pancreatic Cancer
[Nature Reviews Clinical Oncology] The authors explore specific areas with potential for therapeutic advances, including targeting mutant KRAS, novel strategies to harness the antitumour immune response and approaches to early detection.
Sciellin Inhibits Senescence and Promotes Pancreatic Cancer Progress by Activating the Notch Signaling Pathway
[Scientific Reports] In vivo and in vitro assays were performed to investigate the role of sciellin in pancreatic cancer cell senescence, proliferation, invasion, and metastasis.
RSPO1, a Potent Inducer of Pancreatic β Cell Neogenesis
[Cell Reports Medicine] Investigators reported the identification of RSPO1 as an inducer of β cell replication. They provided evidence that RSPO1 promotes a significant increase in β cell neogenesis in vitro, ex vivo, and in vivo.
Restoration of Intestinal Secondary Bile Acid Synthesis: A Potential Approach to Improve Pancreatic β Cell Function in Type 1 Diabetes
[Cell Reports Medicine] Scientists investigate the roles of gut microbiome and secondary bile acid dysfunctions in type 1 diabetes and explored targeted interventions to address them.
Beta Cells Intrinsically Sense and Limit Their Secretory Activity via mTORC1-RhoA Signaling
[Cell Reports] The authors identified a glucose–mTORC1–RhoA signaling axis that forms an autonomous feedback loop to constrain insulin exocytosis.
Modeling Diabetic Alpha Cell Dysfunction Using Stem Cell-Derived Alpha Cells
[Stem Cell Reports] Researchers showed that induction of endoplasmic reticulum stress in stem cell-derived alpha cells induces hypersecretion of glucagon.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
